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Published on: 3/5/2025

When Does Age-Related Macular Degeneration (AMD) Start?

Age-related macular degeneration (AMD) mainly begins in older adults, with early signs typically emerging after the age of 50. As people get older, the risk of developing AMD increases.

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Explanation

AMD is called “age-related” because it is most often seen in older people. The condition usually starts to show early changes in the retina after age 50, though many individuals may not notice any symptoms at the beginning. At first, small changes in the macula, the part of the retina that helps with sharp, detailed vision, can occur little by little. Over time, these changes can lead to more serious forms of AMD that might affect vision, especially the type known as neovascular AMD, which involves the growth of abnormal blood vessels. Risk factors such as genetics and lifestyle can also play a role, but age is a key factor. In short, while some early signs of AMD might start in mid-adulthood, the condition is most common and becomes a major concern in later years, often in the 70s and beyond. Regular eye checks can help catch early signs of AMD and guide proper management.

(References)

  • Pugazhendhi A, Hubbell M, Jairam P, Ambati B. Neovascular Macular Degeneration: A Review of Etiology, Risk Factors, and Recent Advances in Research and Therapy. Int J Mol Sci. 2021 Jan 25;22(3):1170. doi: 10.3390/ijms22031170. PMID: 33504013; PMCID: PMC7866170.

  • Ricci F, Bandello F, Navarra P, Staurenghi G, Stumpp M, Zarbin M. Neovascular Age-Related Macular Degeneration: Therapeutic Management and New-Upcoming Approaches. Int J Mol Sci. 2020 Nov 3;21(21):8242. doi: 10.3390/ijms21218242. PMID: 33153227; PMCID: PMC7662479.

  • Shao J, Choudhary MM, Schachat AP. Neovascular Age-Related Macular Degeneration. Dev Ophthalmol. 2016;55:125-36. doi: 10.1159/000438969. Epub 2015 Oct 26. PMID: 26501146.

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