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Published on: 8/18/2026

Why do I get diarrhea on antibiotics?

Antibiotic-associated diarrhea occurs when antibiotics disrupt the natural balance of good and bad bacteria in your gut microbiome. This imbalance allows harmful bacteria, such as Clostridioides difficile (C. diff), to multiply and cause loose stools, cramping, or more serious infection. Symptoms can appear during treatment or weeks after finishing antibiotics.

Because diarrhea can also signal other conditions, it's important to identify the cause quickly. Take a free, instant, online symptom check to better understand your symptoms and confidently navigate your next steps.

Reviewed for medical accuracy: 07/15/2026

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Explanation

When you take antibiotics, they can disturb the natural balance of bacteria in your intestines. This disruption can lead to diarrhea, which is a common side effect.

Here's how it happens:

  1. Good and Bad Bacteria: Your gut is full of both good and bad bacteria. Antibiotics can kill both types, which can upset the balance.
  2. C. difficile Infections: Sometimes, this imbalance allows harmful bacteria like C. difficile to grow, which can cause more severe diarrhea. It commonly occurs in older adults. In such cases, a lower gastrointestinal endoscopy is required for diagnosis, and treatment involves the use of metronidazole or vancomycin.
  3. Mild to Severe Symptoms: While some people may experience mild diarrhea, others can have more serious symptoms if C. difficile is involved.

Most of the time, antibiotic-associated diarrhea is mild and goes away on its own. However, if you're experiencing concerning digestive symptoms, you can check your symptoms with our free AI-powered tool to better understand what might be causing them and whether you should seek medical care.

(References)

  • Varughese CA, Vakil NH, & Phillips KM. (2013). Antibiotic-associated diarrhea: a refresher on causes and .... Journal of pharmacy practice, 24064436.

  • Surawicz CM. (2005). Antibiotic-associated Diarrhea and Pseudomembranous .... Chemotherapy, 15855751.

  • Capurso L, & Koch M. (2021). [Side effects of antibiotic: diarrhea and Clostridium difficile .... Recenti progressi in medicina, 33576348.

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