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Published on: 3/5/2025

Which Blood Pressure Medications Cause Memory Loss?

Some blood pressure medicines—especially older ones like certain beta blockers and centrally acting agents (for example, reserpine)—have been linked to memory loss, though not everyone experiences this side effect.

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Explanation

Research shows that not all blood pressure medications affect memory. Some studies have found that older drugs, such as particular beta blockers that can easily go into the brain and medicines like reserpine that work in the brain, may be more likely to be linked with memory problems in some people. This is thought to happen because these drugs cross the protective barrier around the brain (the blood-brain barrier) and might change the way our memory works. However, other types of blood pressure drugs, like some angiotensin receptor blockers (ARBs) or ACE inhibitors, may actually help keep the brain healthy. Many factors, including a person's age and other health conditions, can also affect memory, so the role of these medications is not entirely clear. If you or someone you know has concerns about memory loss or other side effects from blood pressure medications, it is important to speak with a doctor. Your doctor can help decide which medicine works best for you while keeping an eye on memory and overall brain health.

(References)

  • Marvanova M. Drug-induced cognitive impairment: Effect of cardiovascular agents. Ment Health Clin. 2016 Jun 29;6(4):201-206. doi: 10.9740/mhc.2016.07.201. PMID: 29955471; PMCID: PMC6007720.

  • Yang W, Luo H, Ma Y, Si S, Zhao H. Effects of Antihypertensive Drugs on Cognitive Function in Elderly Patients with Hypertension: A Review. Aging Dis. 2021 Jun 1;12(3):841-851. doi: 10.14336/AD.2020.1111. PMID: 34094646; PMCID: PMC8139194.

  • Ho JK, Moriarty F, Manly JJ, Larson EB, Evans DA, Rajan KB, Hudak EM, Hassan L, Liu E, Sato N, Hasebe N, Laurin D, Carmichael PH, Nation DA. Blood-Brain Barrier Crossing Renin-Angiotensin Drugs and Cognition in the Elderly: A Meta-Analysis. Hypertension. 2021 Sep;78(3):629-643. doi: 10.1161/HYPERTENSIONAHA.121.17049. Epub 2021 Jun 21. PMID: 34148364; PMCID: PMC9009861.

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