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Published on: 10/1/2026
Common side effects of BlueChew's chewable sildenafil and tadalafil include headaches, flushing, nasal congestion, indigestion, dizziness, and back or muscle aches, while rarer but serious reactions can involve vision or hearing changes, chest pain, fainting, and priapism, a painful erection lasting more than four hours that requires emergency care. Risk rises significantly when these PDE5 inhibitors are combined with nitrates, certain blood pressure medications, alpha blockers, or recreational poppers, which can cause a dangerous drop in blood pressure. Duration matters too, since sildenafil clears in about 4 to 6 hours while tadalafil can linger up to 36 hours, meaning side effects may last longer. There are several important factors to consider, including dosing, underlying heart conditions, and warning signs that call for urgent evaluation, so see below for the complete details.
If you are unsure whether what you are feeling is a mild, expected reaction or something that needs medical attention, a free, instant, online symptom check can help you understand your symptoms, flag red flags worth taking seriously, and clarify your next steps before they get worse.
Last reviewed for medical accuracy: 10/01/2026
Blue Chew offers chewable formulations of sildenafil and tadalafil for erectile dysfunction (ED). Both medications belong to a class called phosphodiesterase type 5 (PDE5) inhibitors. While many people tolerate them well, it’s important to know the possible side effects. Below is an overview based on credible sources such as FDA prescribing information and peer-reviewed studies.
Understanding potential side effects helps you use these medications safely and spot warning signs early.
Most side effects are mild to moderate and resolve on their own. They include:
These symptoms generally don’t require medical attention unless they persist more than a few days or interfere with daily life.
Some users experience side effects less often. These include:
If any of these symptoms become bothersome or severe, consider pausing the medication and checking symptoms via a free, online symptom check, using the doctor approved Ubie Symptom Checker.
While uncommon, certain side effects require immediate medical attention:
Always consider these serious events rare but potentially life-threatening.
Certain factors can increase the likelihood or severity of side effects:
If you fall into any of these groups, discuss risks and benefits with your healthcare provider before starting Blue Chew.
Combining PDE5 inhibitors with certain drugs can be dangerous:
Always provide a complete medication list to your prescriber.
If you’re ever in doubt, use a free, online symptom check, using the doctor approved Ubie Symptom Checker to guide your next steps. And don’t hesitate to seek professional care for any life-threatening or serious issues.
Blue Chew’s sildenafil and tadalafil tablets can be effective and convenient for many men with ED. While most people tolerate them well, being aware of potential side effects—both common and rare—is crucial. Proper dosing, awareness of interactions, and prompt recognition of serious symptoms help ensure safe use.
Always consult your healthcare provider before starting or adjusting any ED medication. And remember: if you have life-threatening or serious concerns, seek medical attention immediately. Speak to your doctor about any symptoms that worry you.
(References)
* Balon R. Fluvoxamine-induced erectile dysfunction responding to sildenafil. J Sex Marital Ther. 1998 Oct-Dec;24(4):313-7. doi: 10.1080/00926239808403967. PMID: 9805292.
* Rosenberg KP. Sildenafil. J Sex Marital Ther. 1999 Oct-Dec;25(4):271-9. doi: 10.1080/00926239908404004. PMID: 10546165.
* Fleshner N, Harvey M, Adomat H, Wood C, Eberding A, Hersey K, Guns E. Evidence for contamination of herbal erectile dysfunction products with phosphodiesterase type 5 inhibitors. J Urol. 2005 Aug;174(2):636-41; discussion 641; quiz 801. doi: 10.1097/01.ju.0000165187.31941.cd. PMID: 16006928.
* Bjekic M, Markovic M, Sipetic S. Fixed drug eruption caused by tadalafil--case report. An Bras Dermatol. 2013 Jul-Aug;88(4):617-9. doi: 10.1590/abd1806-4841.20131994. PMID: 24068137; PMCID: PMC3760941.
* Pitsios C. Erythema multiforme caused by sildenafil in an HIV(+) subject. Eur Ann Allergy Clin Immunol. 2016 Mar;48(2):58-60. PMID: 26934741.
* Grimaux X, Bigot P, Leclec'h C. [Bullous fixed drug eruption of the glands due to tadalafil: A case report]. Prog Urol. 2016 Jun;26(8):435-6. doi: 10.1016/j.purol.2016.05.001. Epub 2016 Jun 17. PMID: 27324211.
* Jayadev C, Ramasastry P, Gul A, Vinekar A. Possible Role of Sildenafil Citrate in the Recurrence of Neovascularization in Laser-regressed Aggressive Posterior ROP. Indian Pediatr. 2016 Nov 7;53 Suppl 2:S155-S156. PMID: 27915325.
* Sharma D, Kumar M, Pandey S, Agarwal S. Penile fracture after priapism due to sildenafil ingestion: out of frying pan into the fire. BMJ Case Rep. 2018 Aug 14;2018. doi: 10.1136/bcr-2018-226562. Epub 2018 Aug 14. PMID: 30108124; PMCID: PMC6101329.
* Negoro H, Goto T, Akamatsu S, Terada N, Kobayashi T, Matsui Y, Yamamoto T, Omura T, Yonezawa A, Matsubara K, Ogawa O. Add-on effects of tadalafil in tamsulosin-treated patients with small benign prostatic enlargement: A randomized, placebo-controlled, double-blind, crossover study. Neurourol Urodyn. 2020 Jan;39(1):237-242. doi: 10.1002/nau.24175. Epub 2019 Oct 2. PMID: 31578771.
* Mahmoud Mohammed A, Abdellah Ali Mostafa E, Reyad AM, Ali Abdelhaleem H, Ahmed Mahmoud T. Effect of mirabegron, tamsulosin, and tadalafil on quality of life in patients with indwelling ureteral (double-J) stents. Actas Urol Esp (Engl Ed). 2026 Jul-Aug;50(6):501980. doi: 10.1016/j.acuroe.2026.501980. Epub 2026 Apr 1. PMID: 41932387.
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