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Published on: 9/22/2026
Common BuSpar (buspirone) side effects include dizziness, drowsiness, headache, nausea, nervousness, lightheadedness, and trouble sleeping, and most are mild and tend to fade within the first one to two weeks as your body adjusts. Dizziness is the most frequently reported effect, while less common reactions such as chest pain, blurred vision, confusion, uncontrolled movements, or signs of serotonin syndrome warrant prompt medical attention. Whether side effects go away depends on your dose, how long you have been taking it, other medications or grapefruit juice you consume, and your individual health history, so there are several important factors to consider before assuming a symptom is harmless or permanent. See below for the full breakdown of which effects typically resolve, which may persist, and when to contact a clinician. If you are unsure whether what you feel is an expected adjustment period or something that needs attention, take a free, instant, online symptom check to better understand your symptoms and decide on your next steps in minutes.
Last reviewed for medical accuracy: 09/22/2026
Buspar (buspirone) is a prescription medication commonly used to treat anxiety disorders. Like any drug, it can cause side effects. Understanding which reactions are common, how long they last, and when to seek help can make your experience with Buspar smoother and less worrisome.
Most people tolerate Buspar well, but you may notice some mild reactions, especially during the first few weeks. These often improve as your body adjusts:
Dizziness or lightheadedness
Feeling unsteady or a bit woozy, particularly when standing up quickly.
Headache
Mild to moderate headaches may occur, usually fading over time.
Nausea or upset stomach
An unsettled stomach, sometimes with mild indigestion.
Drowsiness or fatigue
You might feel more tired than usual, especially in the first days of treatment.
Nervousness or restlessness
Some people report a paradoxical increase in anxiety or jitteriness at the start.
Dry mouth
A cottonmouth sensation, which is generally mild.
Tremor
Slight shaking of the hands or fingers.
Blurred vision
Temporary difficulty focusing, usually mild.
Sweating
Increased perspiration, often short-lived.
In most cases, yes. Here’s what you can generally expect:
Adjustment period
– Side effects are most common during the first 1–2 weeks.
– Your body needs time to adapt to the change in brain chemistry.
Tapering off
– Many people find that side effects gradually lessen or disappear by weeks 3–4.
– If you still feel unwell after a month, talk to your doctor about possible dose adjustments.
Individual variation
– Everyone reacts differently. Some breeze through with minimal discomfort; others may have lingering mild symptoms.
While most reactions are mild, a few require prompt medical attention:
If you experience any of these, seek immediate medical help:
Allergic reactions
– Hives, rash, itching
– Swelling of the face, lips, tongue, or throat
– Difficulty breathing or swallowing
Confusion or hallucinations
Severe dizziness or fainting
Jaundice (yellowing of skin/eyes)
Uncontrolled movements (especially of the face or tongue)
Speak with your healthcare provider if you notice:
For non-urgent questions or to track your symptoms, consider a free, online symptom check, using the doctor-approved Ubie Symptom Checker. It’s a quick way to get personalized guidance on what to do next.
Your doctor may:
Never change your dose or stop taking Buspar without consulting your healthcare provider.
Buspar can be an effective tool for managing anxiety, and most side effects are mild and temporary. By knowing what to expect and when to seek help, you can feel more confident as you start treatment. Always keep an open line of communication with your doctor. If anything feels seriously wrong or life-threatening, seek immediate medical attention.
Remember, this information is educational and not a substitute for professional medical advice. Speak to your doctor about any concerns or symptoms that worry you.
(References)
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* Drossman DA, Tack J, Ford AC, Szigethy E, Törnblom H, Van Oudenhove L. Neuromodulators for Functional Gastrointestinal Disorders (Disorders of Gut-Brain Interaction): A Rome Foundation Working Team Report. Gastroenterology. 2018 Mar;154(4):1140-1171.e1. doi: 10.1053/j.gastro.2017.11.279. Epub 2017 Dec 22. PMID: 29274869.
* Drugs for Depression. Med Lett Drugs Ther. 2020 Feb 24;62(1592):25-32. PMID: 32320387.
* DeBattista C, Schatzberg AF. The Black Book of Psychotropic Dosing and Monitoring. Psychopharmacol Bull. 2024 Jul 8;54(3):8-59. doi: 10.64719/pb.4493. PMID: 38993656; PMCID: PMC11235576.
* Nunes JC, Botas JL. A Serotonin "Cocktail". Prim Care Companion CNS Disord. 2020 Jul 2;22(4). doi: 10.4088/PCC.19l02532. Epub 2020 Jul 2. PMID: 32628370.
* Perlman SL. Cerebellar Ataxia. Curr Treat Options Neurol. 2000 May;2(3):215-224. doi: 10.1007/s11940-000-0004-3. PMID: 11096749.
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