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Published on: 11/7/2025
Is it okay to take antihistamines every day?
Taking antihistamines every day can be safe, especially with second-generation antihistamines, which are less likely to cause drowsiness. However, it's important to follow medical advice for your specific needs. See below to understand more.
Worried about antihistamine use?
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Antihistamines are often used to help with allergies. Some people wonder if it's okay to take them every day. According to the medical literature, taking antihistamines daily can be safe, especially when using second-generation antihistamines.
Second-Generation Antihistamines
- Second-generation antihistamines are designed to cause less drowsiness and have fewer side effects. This makes them safer for daily use (Reference 2).
Daily vs. As-Needed Use
- Some studies, like one comparing daily desloratadine use to as-needed use, suggest that taking antihistamines daily can improve quality of life for people with persistent allergy symptoms (Reference 1).
On-Demand Use
- On-demand use of non-sedating antihistamines can also be effective for controlling symptoms, but daily use may provide more consistent relief (Reference 3).
In conclusion, while daily use of antihistamines, especially second-generation ones, is generally considered safe, it's important to follow medical advice tailored to your specific health needs.
(References)
- Grob JJ, Auquier P, Dreyfus I, & Ortonne JP. (2009). desloratadine daily vs PRN and quality of life. Allergy, 19133920.
- Philpot EE. (2000). Safety of second generation antihistamines. Allergy and asthma proceedings, 10748947.
- Weller K, Ardelean E, Scholz E, Martus P, Zuberbier T, & Maurer M. (2013). Can on-demand non-sedating antihistamines improve .... Acta dermato-venereologica, 23053062.
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