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Published on: 8/20/2026
Pain affecting the entire left side of the body is typically diagnosed through a combination of a detailed neurologic exam, sensory testing, and imaging studies. Doctors may also perform a skin biopsy to evaluate small nerve fiber function, along with blood work or MRI scans to rule out underlying conditions such as nerve damage, stroke, or spinal cord issues.
Because left-sided pain can stem from many possible causes—ranging from pinched nerves to more serious neurological conditions—it's important not to guess. Taking a free, instant, online symptom check can help you clarify what may be causing your pain and guide you toward the right next steps, whether that's home care or seeing a specialist.
Reviewed for medical accuracy: 07/15/2026
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If you're experiencing pain from head to toe on the left side of your body, your doctor will want to investigate whether it is coming from nerve issues or other conditions. They usually start with a complete neurologic exam. This exam checks your strength, reflexes, and responses to see if there are any signs of nerve problems. One way to look at the nerves is to test your sensitivity to touch; tools like von Frey monofilaments are used to measure how you feel pain or pressure on your skin. They could also do a nerve conduction study or electromyogram (muscle test). If there is a suspicion of small nerve fiber problems causing your pain, your doctor might recommend a neurodiagnostic skin biopsy. This test involves taking a small sample of skin to do a more detailed analysis of your nerve fibers. In cases where a condition like fibromyalgia might be involved, the doctor will also take a full medical history and your symptoms into account. Before your appointment, you can use Ubie's free AI symptom checker to help organize and understand your symptoms, which can make your conversation with your doctor more productive. All these tests together help in diagnosing the cause of your unilateral pain so that the proper treatment can be planned.
(References)
Buonocore M. Unilateral peripheral neuropathic pain: The role of neurodiagnostic skin biopsy. World J Clin Cases. 2014 Feb 16;2(2):27-31. doi: 10.12998/wjcc.v2.i2.27. PMID: 24579067; PMCID: PMC3936215.
Keizer D, van Wijhe M, Post WJ, Wierda JM. Quantifying allodynia in patients suffering from unilateral neuropathic pain using von frey monofilaments. Clin J Pain. 2007 Jan;23(1):85-90. doi: 10.1097/01.ajp.0000210950.01503.72. PMID: 17277649.
Shahrokhi M, Asuncion RMD. Neurologic Exam. [Updated 2023 Jan 16]. In: StatPearls [Internet].
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