Our Services
Medical Information
Helpful Resources
Published on: 9/13/2026
Dicyclomine (Bentyl) is an anticholinergic antispasmodic approved for functional bowel and irritable bowel syndrome, so it eases IBS cramping and intestinal spasms, not only upper stomach spasms. It relaxes smooth muscle throughout the gut and works best taken 30 to 60 minutes before meals during a flare, though it does not reliably fix diarrhea, constipation, bloating or gas, and it is not meant for long term daily use. Dosing, onset, side effects such as dry mouth, blurred vision, drowsiness and constipation, plus who should avoid it, are all important details, and there are several factors to consider before assuming it will help your cramps, so read the complete answer below.
Cramping that keeps returning is not always IBS, since infections, inflammatory bowel disease, celiac disease, endometriosis, gallbladder problems and medication side effects can all mimic it, and an antispasmodic can mask a cause that needs different treatment. If you are unsure whether your cramps fit IBS or something else, take a free, instant, online symptom check to clarify your likely causes and understand which next steps, and which conversation with a clinician, make the most sense for you.
Last reviewed for medical accuracy: 09/13/2026
Dicyclomine (brand name Bentyl) is a prescription medication classified as an anticholinergic and antispasmodic agent. It’s primarily used to relieve smooth muscle spasms in the gastrointestinal (GI) tract. Doctors often prescribe it for:
Dicyclomine blocks acetylcholine, a neurotransmitter that triggers muscle contractions in the gut. By reducing these contractions, it can:
Since IBS-related cramps result from involuntary spasms in the intestines, dicyclomine’s antispasmodic action directly targets the root cause. In other words, it doesn’t just treat “stomach” spasms—it can relieve spasms throughout the GI tract, including those typical of IBS.
Yes. Clinical evidence and real-world experience support the use of dicyclomine for IBS-related cramping. Key points include:
Dosages can vary based on patient age, symptom severity, and other health factors. Common guidelines:
Always follow your doctor’s prescription. Do not increase your dose or frequency without medical advice.
While many people tolerate dicyclomine well, it can cause anticholinergic side effects. Common adverse effects:
Less common but more serious side effects include:
Precautions:
Discuss the following with your doctor before starting dicyclomine:
Dicyclomine can interact with other medications and substances:
Contraindications include:
Always review your full medication list with your healthcare provider to avoid harmful interactions.
Dicyclomine works best when combined with other IBS-friendly habits:
Track key indicators to gauge how well dicyclomine—or any IBS therapy—is working:
For a quick, free, online check of current symptoms, consider using the doctor approved Ubie Symptom Checker. It can help you decide if your signs point to IBS activity or something more serious.
Contact your healthcare provider immediately if you experience any of the following:
These could indicate a more serious condition requiring prompt medical care.
Remember, this information is not a substitute for medical advice. Speak to your healthcare provider about any concerns, especially if you have conditions that could be life threatening or require urgent attention.
(References)
* Wald A. Irritable Bowel Syndrome. Curr Treat Options Gastroenterol. 1999 Feb;2(1):13-19. doi: 10.1007/s11938-999-0013-6. PMID: 11096567.
* Nee J, Zakari M, Lembo AJ. Novel Therapies in IBS-D Treatment. Curr Treat Options Gastroenterol. 2015 Dec;13(4):432-40. doi: 10.1007/s11938-015-0068-5. PMID: 26432092.
* Rahman HMA, Bashir S, Mandukhail SR, Huda S, Gilani AH. Pharmacological Evaluation of Gut Modulatory and Bronchodilator Activities of Achyranthes aspera Linn. Phytother Res. 2017 Nov;31(11):1776-1785. doi: 10.1002/ptr.5907. Epub 2017 Aug 25. PMID: 28840614.
* Dicyclomine. 2012. PMID: 31644199.
* Drugs for Irritable Bowel Syndrome. Med Lett Drugs Ther. 2020 Mar 23;62(1594):25-32. PMID: 32324172.
* Brenner DM, Lacy BE. Antispasmodics for Chronic Abdominal Pain: Analysis of North American Treatment Options. Am J Gastroenterol. 2021 Aug 1;116(8):1587-1600. doi: 10.14309/ajg.0000000000001266. PMID: 33993133; PMCID: PMC8315189.
* Jafari S, Sajedi B, Jameshorani M, Salarpour F. Comparison of fluoxetine and duloxetine hydrochloride therapeutic effects on patients with constipation-predominant irritable bowel syndrome. Gastroenterol Hepatol Bed Bench. 2022 Winter;15(1):45-52. PMID: 35611252; PMCID: PMC9123635.
* Ali A, Saqib F. Ethnopharmacological basis and pharmacodynamics prospectives for folkloric claims of Rosa webbiana wall. Ex. Royle in diarrhea and asthma via In vitro, In vivo and In silico techniques. J Ethnopharmacol. 2023 Dec 5;317:116696. doi: 10.1016/j.jep.2023.116696. Epub 2023 Jun 12. PMID: 37315649.
* Drugs for irritable bowel syndrome. Med Lett Drugs Ther. 2025 Feb 3;67(1721):17-24. doi: 10.58347/tml.2025.1721a. PMID: 39912839.
* Singh P, Lee A, Sheth NM, Chey WD. Chronic, Noninfectious Diarrhea: A Review. JAMA. 2026 Apr 14;335(14):1250-1262. doi: 10.1001/jama.2026.0872. PMID: 41770539.
We would love to help them too.
For First Time Users
We provide a database of explanations from real doctors on a range of medical topics. Get started by exploring our library of questions and topics you want to learn more about.
Was this page helpful?
Purpose and positioning of servicesUbie Doctor's Note is a service for informational purposes. The provision of information by physicians, medical professionals, etc. is not a medical treatment. If medical treatment is required, please consult your doctor or medical institution. We strive to provide reliable and accurate information, but we do not guarantee the completeness of the content. If you find any errors in the information, please contact us.