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Published on: 3/5/2025

Does Izervay Work Immediately?

Izervay is not designed to work immediately. It is intended to slow the progression of vision loss in geographic atrophy over time.

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Explanation

Izervay, also known as avacincaptad pegol, is a treatment to help slow vision loss in patients with geographic atrophy rather than to fix vision right away. After you receive an injection, the medicine begins working at a cellular level to help protect and preserve your vision. However, you will not notice a quick or immediate improvement in how you see. Instead, over many months of treatment, Izervay can reduce the speed at which vision loss happens. This treatment works gradually by targeting processes in the eye that lead to damage. It is similar to some other medicines where the benefit is seen by the long-term slowing of a disease’s progress. Because of this gradual effect, it is very important to follow up with your eye doctor regularly during treatment so they can monitor your condition and adjust care as needed. Remember, if you have any questions about your treatment or if you’re not sure how it is working, you should talk with your healthcare provider.

(References)

  • Khanani AM, Patel SS, Staurenghi G, Tadayoni R, Danzig CJ, Eichenbaum DA, Hsu J, Wykoff CC, Heier JS, Lally DR, Monés J, Nielsen JS, Sheth VS, Kaiser PK, Clark J, Zhu L, Patel H, Tang J, Desai D, Jaffe GJ; GATHER2 trial investigators. Efficacy and safety of avacincaptad pegol in patients with geographic atrophy (GATHER2): 12-month results from a randomised, double-masked, phase 3 trial. Lancet. 2023 Oct 21;402(10411):1449-1458. doi: 10.1016/S0140-6736(23)01583-0. Epub 2023 Sep 8. PMID: 37696275.

  • Shakeel L, Khan A, Akilimali A. "Izervay (avacincaptad pegol): paving the way for vision preservation in geographic atrophy". Ann Med Surg (Lond). 2024 Apr 3;86(5):2413-2416. doi: 10.1097/MS9.0000000000002021. PMID: 38694318; PMCID: PMC11060312.

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