How does enobosarm compare to placebo for lean mass preservation?

Reviewed by Yoshinori Abe, MD

Internal Medicine

Enobosarm, a selective androgen receptor modulator (SARM), has demonstrated in clinical trials the ability to preserve lean body muscle mass more effectively than a placebo. Studies show participants taking enobosarm experienced measurable improvements in muscle retention, making it a subject of ongoing research for conditions involving muscle wasting, such as cancer cachexia and age-related sarcopenia.

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Reviewed for medical accuracy: 07/20/2026

Important Next Steps

Discover if enobosarm affects your lean mass Learn likely benefits and risks of enobosarm See if enobosarm is right for you Find OTC options for muscle loss support Find doctors for muscle-building treatment advice Understand home remedies for lean mass support Find out if placebo comparison changes outcomes

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Explanation

Enobosarm is a type of drug known as a Selective Androgen Receptor Modulator (SARM). In a study involving enobosarm, participants who took the drug showed better preservation of lean body mass compared to those who took a placebo.

Key Points:

Study Design: The study was a double-blind, randomized controlled trial. This means neither the participants nor the researchers knew who was receiving enobosarm or the placebo, which helps ensure unbiased results.
Results: Participants taking enobosarm maintained more muscle mass than those on the placebo.

Why It Matters:

Muscle Preservation: Keeping muscle mass is important for overall health, especially in conditions that cause muscle wasting.
Potential Benefits: Enobosarm could be beneficial for people who need to maintain muscle mass due to illness or aging.

If you're experiencing unexplained muscle loss or weakness, it's important to identify the underlying cause. Try Ubie's free AI-powered symptom checker to help understand what might be affecting your muscle health.

(References)

Dobs AS, Boccia RV, Croot CC, Gabrail NY, Dalton JT, Hancock ML, et al. (2013). a double-blind, randomised controlled phase 2 trial. The Lancet. Oncology, 23499390.
Crawford J, Prado CM, Johnston MA, Gralla RJ, Taylor RP, Hancock ML, & Dalton JT. (2016). Study Design and Rationale for the Phase 3 Clinical .... Current oncology reports, 27138015.
Neil D, Clark RV, Magee M, Billiard J, Chan A, Xue Z, & Russell A. (2018). GSK2881078, a SARM, Produces Dose-Dependent .... The Journal of clinical endocrinology and metabolism, 29982690.

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