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Published on: 4/7/2025

What Are the Most Effective Treatments for a Fungal Nail Infection?

The best treatments for fungal nail infections often include oral antifungal medications which work by reaching the fungus from inside the nail, and topical treatments like creams or lacquers, sometimes combined with device-based therapies.

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Explanation

Fungal nail infections, also known as onychomycosis, can be hard to treat because the fungus lives inside and under the nail. One of the most effective treatments is an oral antifungal medication. These are pills that fight the fungus from the inside out and usually work better than topical treatments. However, because these pills can sometimes cause side effects, doctors will need to assess your overall health carefully before prescribing them. Topical treatments, such as antifungal creams, solutions, or nail lacquers, are applied directly to the nail and can help, especially if the infection is mild. Some newer approaches involve device-based treatments like lasers, though these methods are still being studied. Often, doctors may recommend a mix of these treatments to get the best results. Good nail care—keeping your nails clean, dry, and trimmed—also supports the treatment. Always follow your doctor’s instructions and complete your course of treatment to help clear the infection completely.

(References)

  • Crawford F, Hollis S. Topical treatments for fungal infections of the skin and nails of the foot. Cochrane Database Syst Rev. 2007 Jul 18;2007(3):CD001434. doi: 10.1002/14651858.CD001434.pub2. PMID: 17636672; PMCID: PMC7073424.

  • Foley K, Gupta AK, Versteeg S, Mays R, Villanueva E, John D. Topical and device-based treatments for fungal infections of the toenails. Cochrane Database Syst Rev. 2020 Jan 16;1(1):CD012093. doi: 10.1002/14651858.CD012093.pub2. PMID: 31978269; PMCID: PMC6984586.

  • Cologne, Germany: Institute for Quality and Efficiency in Health Care (IQWiG); 2006-. Nail fungus: Learn More – Nail fungus: Polish, cream or tablets? [Updated 2022 Dec 2]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK279546/

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