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Published on: 7/14/2026

What might be the reason for having hot palms and soles?

Hot palms and soles are commonly caused by conditions that affect blood flow and nerve activity in the hands and feet. Frequent culprits include palmar hyperhidrosis (excessive sweating), hand-foot syndrome (a reaction to certain medications), peripheral neuropathy, and hormonal changes such as those seen in menopause or thyroid disorders. In some cases, vitamin deficiencies, infections, or circulation issues may also play a role.

Because these underlying causes vary widely—from harmless to serious—identifying the source of your symptoms is essential to getting the right care. Rather than guessing, take a few minutes to complete a free, AI-powered symptom check. It's instant, private, and can help you understand what's likely behind your hot palms and soles, plus guide you on the best next steps to take.

Reviewed for medical accuracy: 07/14/2026

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Explanation

When you notice your palms and soles feeling hot, it may be caused by changes in how your body controls temperature and sweating. For example, in conditions like palmar hyperhidrosis, the nerves send strong signals to your sweat glands, which can make your hands and feet warmer and sometimes even trigger extra sweating. There is also something called hand-foot syndrome, where your skin on the palms and soles becomes red, hot, and sometimes painful. This syndrome may be seen in certain reactions, such as those related to medications or other underlying conditions. Research has found that altering nerve signals near your spine can change how your hands and feet feel, suggesting that the nervous system plays an important role in controlling the temperature of these areas. If you are experiencing persistent discomfort, you can use our free symptom checker to better understand what might be causing your symptoms, and talk with a healthcare provider who can help determine if these conditions are the cause and if any treatments may help keep your hands and soles feeling more comfortable.

(References)

  • Jeong SM, Kim TY, Jeong YB, et al. The changes of skin temperature on hands and feet during and after T3 sympathicotomy for palmar hyperhidrosis. _J Korean Med Sci_. 2006;21(5):917–921. doi:10.3346/jkms.2006.21.5.917. PMCID: PMC2722005. PMID: 17043429.

  • Braghiroli CS, Ieiri R, Ocanha JP, Paschoalini RB, Miot HA. Do you know this syndrome? Hand-foot syndrome. _An Bras Dermatol_. 2017;92(1):131–133. doi:10.1590/abd1806-4841.20174602. PMCID: PMC5312196. PMID: 28225974.

  • Evans RJ, Watson CPN. The hot foot syndrome: Evans' sign and the old way. _Pain Res Manag_. 2012;17(1):31–34. doi:10.1155/2012/658730. PMCID: PMC3299035. PMID: 22518365.

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