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Published on: 8/20/2026

What is izervay used for?

Izervay (avacincaptad pegol) is a prescription eye injection used to slow the progression of geographic atrophy (GA) secondary to age-related macular degeneration (AMD). Administered monthly by an ophthalmologist, Izervay works by inhibiting complement protein C5, helping to reduce the retinal cell damage that leads to central vision loss.

If you're experiencing blurred vision, blind spots, or difficulty seeing in low light, these could be early warning signs of AMD or geographic atrophy—conditions where early detection matters most. Understanding your symptoms is the first step toward protecting your sight and knowing when to see a specialist. Take a free, instant, and confidential symptom check to better understand what may be causing your vision changes and get guidance on your next steps.

Reviewed for medical accuracy: 07/15/2026

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Izervay, which contains avacincaptad pegol, is a treatment for geographic atrophy, a type of advanced age-related macular degeneration (AMD). Geographic atrophy causes gradual loss of vision because cells in the retina slowly break down, leading to blurred or missing areas in vision. Izervay works by blocking a part of the immune response called the complement system, specifically targeting a protein known as C5. By doing this, it helps reduce inflammation and damage in the retina. This treatment does not restore lost vision immediately; instead, its purpose is to protect the remaining healthy cells and slow down further vision loss over time. The medicine is given as an injection into the eye and is monitored by an eye care professional during follow-up visits. Understanding that it is a long-term treatment strategy is important, as the benefits build up gradually. If you're experiencing vision changes or have concerns about your eye health, you can start by using a free symptom checker before discussing treatment options like Izervay with your eye doctor, who can provide care tailored to your specific condition.

(References)

  • Jaffe GJ, Westby K, Csaky KG, Monés J, Pearlman JA, Patel SS, Joondeph BC, Randolph J, Masonson H, Rezaei KA. C5 Inhibitor Avacincaptad Pegol for Geographic Atrophy Due to Age-Related Macular Degeneration: A Randomized Pivotal Phase 2/3 Trial. Ophthalmology. 2021 Apr;128(4):576-586. doi: 10.1016/j.ophtha.2020.08.027. Epub 2020 Sep 1. PMID: 32882310.

  • Danzig CJ, Khanani AM, Loewenstein A. C5 inhibitor avacincaptad pegol treatment for geographic atrophy: A comprehensive review. Immunotherapy. 2024;16(12):779-790. doi: 10.1080/1750743X.2024.2368342. Epub 2024 Jul 29. PMID: 39073397; PMCID: PMC11457614.

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