Published on: 3/5/2025
Izervay is used to slow the progression of geographic atrophy due to age-related macular degeneration.
Izervay, which contains avacincaptad pegol, is a treatment for geographic atrophy, a type of advanced age-related macular degeneration (AMD). Geographic atrophy causes gradual loss of vision because cells in the retina slowly break down, leading to blurred or missing areas in vision. Izervay works by blocking a part of the immune response called the complement system, specifically targeting a protein known as C5. By doing this, it helps reduce inflammation and damage in the retina. This treatment does not restore lost vision immediately; instead, its purpose is to protect the remaining healthy cells and slow down further vision loss over time. The medicine is given as an injection into the eye and is monitored by an eye care professional during follow-up visits. Understanding that it is a long-term treatment strategy is important, as the benefits build up gradually. If you have any concerns or questions about Izervay and how it might help preserve your vision, it’s a good idea to discuss these with your eye doctor who can provide care tailored to your specific condition.
(References)
Jaffe GJ, Westby K, Csaky KG, Monés J, Pearlman JA, Patel SS, Joondeph BC, Randolph J, Masonson H, Rezaei KA. C5 Inhibitor Avacincaptad Pegol for Geographic Atrophy Due to Age-Related Macular Degeneration: A Randomized Pivotal Phase 2/3 Trial. Ophthalmology. 2021 Apr;128(4):576-586. doi: 10.1016/j.ophtha.2020.08.027. Epub 2020 Sep 1. PMID: 32882310.
Danzig CJ, Khanani AM, Loewenstein A. C5 inhibitor avacincaptad pegol treatment for geographic atrophy: A comprehensive review. Immunotherapy. 2024;16(12):779-790. doi: 10.1080/1750743X.2024.2368342. Epub 2024 Jul 29. PMID: 39073397; PMCID: PMC11457614.
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