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Published on: 9/13/2026
Pausing Jardiance (empagliflozin) during prolonged fasting, vomiting, diarrhea, or reduced fluid and food intake is often recommended as part of standard "sick day" guidance, because dehydration and low carbohydrate intake raise the risk of euglycemic diabetic ketoacidosis, a serious condition that can occur even when blood sugar looks normal. That said, the decision depends on your specific situation, including how long the illness or fast lasts, your other medications, and your kidney function, so there are important details and warning signs to review below before stopping or restarting the drug on your own.
If you are currently dealing with a stomach bug, nausea, unusual fatigue, fruity breath, rapid breathing, or confusion while taking an SGLT2 inhibitor, those symptoms deserve prompt attention rather than a wait and see approach. A free, instant, online symptom check can help you organize what you are feeling, gauge how urgent it may be, and clarify which questions to bring to your prescriber or pharmacist. It takes only a few minutes and gives you a clearer starting point for deciding whether to seek same day care or safely monitor at home.
Last reviewed for medical accuracy: 09/13/2026
Is It Safe to Skip Jardiance on Days You’re Fasting or Have a Stomach Bug?
If you take Jardiance (empagliflozin) to help manage type 2 diabetes, you may wonder whether it’s okay to miss a dose when you’re fasting or dealing with a stomach virus. Skipping medication can affect your blood sugar control, but so can low fluid intake and illness. Below, we’ll review what’s known about Jardiance, its side effects, and practical guidelines for “sick days” and fasting days. Always work with your health care team to build a personalized plan.
1. What Is Jardiance and Why It Matters
Jardiance is part of a group of drugs called SGLT2 inhibitors. It helps lower blood sugar by causing the kidneys to remove excess glucose through urine. In large clinical trials, Jardiance has also been shown to reduce the risk of heart failure and kidney complications in people with type 2 diabetes.
Key points:
2. Common Jardiance Side Effects
Like any medication, Jardiance can cause side effects. Knowing these helps you weigh the risks of continuing versus pausing treatment:
Being aware of these helps you spot problems early and decide whether to continue or pause your dose on challenging days.
3. Fasting and Jardiance—What You Should Know
People fast for various reasons—religious, medical, or weight management. By reducing or eliminating caloric intake, fasting can change how your body processes glucose and fluids.
Potential concerns:
General guidance (but check with your doctor):
4. Sick Days and Stomach Bugs
A stomach flu—vomiting, diarrhea, poor appetite—can disrupt your diabetes care routine:
Why you might pause Jardiance:
When to consider holding Jardiance on a sick day:
If you pause, resume once you can tolerate fluids, are eating normally, and your blood sugar and kidney function are stable.
5. Balancing Risks and Benefits
Stopping Jardiance without a plan can lead to higher blood sugar. However, continuing during severe dehydration or fasting may lead to dangerous complications.
Consider these steps:
6. Signs You Need Medical Attention
Whether you’re fasting or fighting a bug, watch for serious warning signs. Contact your doctor or go to the emergency department if you experience:
7. Practical Tips for Safe Management
• Prep ahead: Keep your provider’s phone number handy.
• Pack a “sick kit”: Juice boxes, glucose tablets, electrolyte packets, ketone strips.
• Set alarms: Reminders for blood sugar checks and fluid breaks.
• Lean on resources: Consider a free, online symptom check, using the doctor approved Ubie Symptom Checker to guide your next steps if you’re not sure what to do.
• Communicate: Let family or friends know your plan so they can help if you get too sick to manage on your own.
8. Key Takeaways
9. When in Doubt, Speak to Your Doctor
This information is based on clinical guidelines and Jardiance’s prescribing information. It’s not a substitute for personalized medical advice. If you experience any life-threatening or serious symptoms, contact your health care provider or go to the nearest emergency department right away. Always consult your doctor before making changes to how you take Jardiance or any other medication.
(References)
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* Taylor SI, Cherng HR, Shahidzadeh Yazdi Z, Montasser ME, Whitlatch HB, Mitchell BD, Shuldiner AR, Streeten EA, Beitelshees AL. Pharmacogenetics of sodium-glucose co-transporter-2 inhibitors: Validation of a sex-agnostic pharmacodynamic biomarker. Diabetes Obes Metab. 2023 Dec;25(12):3512-3520. doi: 10.1111/dom.15246. Epub 2023 Aug 22. PMID: 37608471; PMCID: PMC10829524.
* Girardi ACC, Polidoro JZ, Castro PC, Pio-Abreu A, Noronha IL, Drager LF. Mechanisms of heart failure and chronic kidney disease protection by SGLT2 inhibitors in nondiabetic conditions. Am J Physiol Cell Physiol. 2024 Sep 1;327(3):C525-C544. doi: 10.1152/ajpcell.00143.2024. Epub 2024 Jun 17. PMID: 38881421.
* Guo L, Xi Y, Jin W, Yuan H, Qin G, Chen S, Zhang L, Liu Y, Cheng X, Liu W, Yu D. A 5:2 Intermittent Fasting Meal Replacement Diet and Glycemic Control for Adults With Diabetes: The EARLY Randomized Clinical Trial. JAMA Netw Open. 2024 Jun 3;7(6):e2416786. doi: 10.1001/jamanetworkopen.2024.16786. Epub 2024 Jun 3. PMID: 38904963; PMCID: PMC11193124.
* Vallon V. State-of-the-Art-Review: Mechanisms of Action of SGLT2 Inhibitors and Clinical Implications. Am J Hypertens. 2024 Oct 14;37(11):841-852. doi: 10.1093/ajh/hpae092. PMID: 39017631; PMCID: PMC11471837.
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