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Published on: 9/15/2026
Flank pain can be a sign of a kidney infection (pyelonephritis), which may lead to kidney scarring, reduced function, or sepsis if it is not treated promptly, though stones, muscle strain, and other conditions can cause similar pain. Warning signs that point toward infection include fever, chills, nausea or vomiting, burning during urination, and cloudy, bloody, or foul-smelling urine. Several factors matter here, including how long the pain has lasted, whether one or both sides hurt, and your history of urinary tract infections or stones, so see the details below before deciding what to do next. Because untreated kidney infections can cause permanent damage within days, sorting urgent symptoms from minor ones quickly is worth your time. Take a free, instant, online symptom check to see which conditions match your flank pain and understand whether you should seek same-day care.
Last reviewed for medical accuracy: 09/15/2025
Could Kidney Pain in My Flank Mean I Have an Infection That Could Damage My Kidneys?
Kidney pain—often felt as a dull ache or sharp twinge in your side, just below the ribs—is a signal worth paying attention to. While not every ache in your flank (the area between your ribs and hip) is a kidney problem, infections can sometimes be the culprit. Left untreated, certain infections may harm your kidneys over time.
Location and quality:
• Usually on one side, but can be on both
• Described as a deep ache, throbbing or sharp stab
• May worsen with movement, deep breaths or pressure
Differentiating sources:
• Muscle strain or ligament sprain often feels better with rest
• Kidney stones can cause waves of intense pain and may radiate to the groin
• Infections often bring other symptoms (see next section)
A kidney infection (pyelonephritis) often starts as a lower urinary tract infection (UTI) that travels upward. Key warning signs include:
Fever and chills:
• Sudden temperature spikes, often above 100.4°F (38°C)
• Shaking chills or sweats
Urinary changes:
• Frequent, painful urges to urinate
• Cloudy, dark or foul-smelling urine
• Possible blood in the urine
Systemic symptoms:
• Nausea or vomiting
• Fatigue, general weakness
• Loss of appetite
If you notice flank pain plus any of these signs, an infection may be at play.
When bacteria invade kidney tissue, they can:
Timely diagnosis and treatment are crucial to prevent lasting harm.
If you suspect a kidney infection, a healthcare provider will typically:
Early testing helps ensure you get the right antibiotic quickly.
Most uncomplicated kidney infections respond well to outpatient antibiotic therapy:
For severe or complicated infections (e.g., persistent high fever, dehydration, suspected abscess), hospitalization may be needed for:
Dial emergency services or visit an urgent care center if you experience:
These can signal sepsis or other life-threatening complications.
Once you’ve had a kidney or urinary infection, you can lower your risk of recurrence by:
If you’re unsure whether your flank discomfort and other symptoms could be a kidney infection, consider doing a free, online symptom check, using the doctor approved Ubie Symptom Checker. It can help you understand possible causes and decide when to see a healthcare provider.
Kidney pain in the flank can stem from various issues, but when accompanied by fever, urinary changes or systemic symptoms, an infection could be the cause—and left untreated, it might damage your kidneys. Early recognition, prompt testing and complete treatment are key to protecting your health.
Always speak to a doctor about anything that feels serious or life-threatening. If you’re in doubt about your symptoms or how quickly you need care, seek professional medical advice right away.
(References)
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* Hollingshead C, Luttmann K, Georgescu C. Bilateral emphysematous pyelonephritis. IDCases. 2021;23:e01042. doi: 10.1016/j.idcr.2020.e01042. Epub 2021 Jan 14. PMID: 33532239; PMCID: PMC7823199.
* Desai R, Batura D. A systematic review and meta-analysis of risk factors and treatment choices in emphysematous pyelonephritis. Int Urol Nephrol. 2022 Apr;54(4):717-736. doi: 10.1007/s11255-022-03131-6. Epub 2022 Feb 1. PMID: 35103928.
* Zhang K, Panisurya T, Srinivasan A, Khawaja H, Qadri A, Ali Z. Cardioembolic-related renal infarction. Proc (Bayl Univ Med Cent). 2022;35(4):529-530. doi: 10.1080/08998280.2022.2065085. Epub 2022 Apr 27. PMID: 35754605; PMCID: PMC9196767.
* Mulayamkuzhiyil Saju J, Leslie SW. Renal Infarction. 2026 Jan. PMID: 35881744.
* Wu SY, Yang SS, Chang SJ, Hsu CK. Emphysematous pyelonephritis: classification, management, and prognosis. Tzu Chi Med J. 2022 Jul-Sep;34(3):297-302. doi: 10.4103/tcmj.tcmj_257_21. Epub 2022 Apr 13. PMID: 35912050; PMCID: PMC9333110.
* Castaigne J, Georges B, Jouret F. [Acute pyelonephritis]. Rev Med Liege. 2022 Sep;77(9):544-547. PMID: 36082603.
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