Published on: 4/28/2025
One-sided pain can come from different places in your body, such as the brain’s pain processing center, your abdominal wall, and it may even be linked to stress. To find relief, it is important to get a proper evaluation and follow a treatment plan that may include medications, therapy, or lifestyle changes.
When one side of your body hurts, it might be caused by a few different things. Sometimes, the brain plays a part. For example, a condition called thalamic pain syndrome occurs when the thalamus, a part of your brain that helps send pain signals, isn’t working properly. There are even special treatments like deep brain stimulation used in severe cases. Other times, pain can come from the muscles or tissues in your abdominal wall. This type of pain might be from muscle strain, inflammation, or injury, and doctors often use specific tests to see if that is the case. Additionally, sometimes pain on one side of the body is linked to stress or emotional factors, a condition called somatization, where the body reacts to feelings with physical pain. To find relief, it is best to consult a healthcare provider. They will ask about your pain, perform an exam, and possibly run tests to know the true cause. Treatments might include pain relievers, physical therapy to strengthen muscles and ease muscle pain, and ways to handle stress better.
(References)
Rezaei Haddad A, Ughratdar I, Ashkan K. A single thalamic target for deep brain stimulation to treat hemi-body pain syndrome. Acta Neurochir (Wien). 2015 Sep;157(9):1519-23. doi: 10.1007/s00701-015-2504-7. Epub 2015 Jul 10. PMID: 26159322.
Shian B, Larson ST. Abdominal Wall Pain: Clinical Evaluation, Differential Diagnosis, and Treatment. Am Fam Physician. 2018 Oct 1;98(7):429-436. PMID: 30252418.
Min SK, Lee BO. Laterality in somatization. Psychosom Med. 1997 May-Jun;59(3):236-40. doi: 10.1097/00006842-199705000-00005. PMID: 9178334.
Cuadrado ML, Young WB, Fernández-de-las-Peñas C, Arias JA, Pareja JA. Migrainous corpalgia: body pain and allodynia associated with migraine attacks. Cephalalgia. 2008 Jan;28(1):87-91. doi: 10.1111/j.1468-2982.2007.01485.x. Epub 2007 Nov 16. PMID: 18021265.
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