Can I take omeprazole long-term?

Reviewed by Yoshinori Abe, MD

Internal Medicine

Omeprazole is generally considered safe for long-term use in many patients, but extended use has been linked to potential risks, including nutrient deficiencies (such as vitamin B12, magnesium, and calcium), bone fractures, kidney issues, and an increased risk of certain infections. Whether long-term use is right for you depends on your individual health, the condition being treated, and your doctor's guidance.

If you're experiencing ongoing symptoms like acid reflux, heartburn, or stomach discomfort, it's worth understanding the root cause before committing to long-term medication. Taking a free, instant, online symptom check can help you identify possible conditions, clarify your next steps, and prepare for a more informed conversation with your doctor—all in just a few minutes.

Reviewed for medical accuracy: 07/15/2026

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Explanation

Omeprazole is a type of medicine called a proton pump inhibitor (PPI). It helps reduce stomach acid. Some people take it for a long time to help with things like acid reflux or ulcers.

Safety of Long-term Use

According to research, omeprazole can be safe for long-term use in many people. However, it may cause changes in the stomach lining.
Another study suggests there might be risks, such as a higher chance of certain health problems. These could include bone fractures or kidney issues.

Considerations

If you need to take omeprazole for a long time, it's important to have regular check-ups with your doctor.
Your doctor can help decide if it's right for you and discuss any possible risks.

Always talk to your doctor before making any changes to how you take your medicine. If you're experiencing ongoing symptoms or want to better understand what might be causing your discomfort, try our free AI symptom checker to get personalized insights before your next appointment.

(References)

Klinkenberg-Knol EC, Nelis F, Dent J, Snel P, Mitchell B, Prichard P, et al. (2000). efficacy, safety, and influence on gastric mucosa. Gastroenterology, 10734017.
Koyyada A. (2021). Long-term use of proton pump inhibitors as a risk factor for .... Therapie, 32718584.
Attwood SE, Ell C, Galmiche JP, Fiocca R, Hatlebakk JG, Hasselgren B, et al. (2015). Long-term safety of proton pump inhibitor therapy .... Alimentary pharmacology & therapeutics, 25858519.

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