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Published on: 11/10/2025

Why does metformin cause stomach upset?

Metformin can cause stomach upset because it affects how your stomach and intestines work, which can lead to symptoms like diarrhea, nausea, and gas. See below to understand more.

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Explanation

Metformin is a common medicine used to help control blood sugar levels in people with diabetes. However, it can cause stomach problems for some people.

How It Affects the Stomach

  • Intestinal Effects: Metformin can change how your intestines absorb sugar, which might lead to diarrhea and stomach upset.
  • Gut Flora: It may also affect the bacteria in your gut, leading to symptoms like gas and bloating.

Managing Stomach Upset

  • Extended-Release Option: Some people find that taking an extended-release form of metformin helps reduce stomach issues because it releases the medicine slowly over time.
  • Starting Slowly: Doctors might start you on a low dose and gradually increase it to help your body get used to the medicine.

If you experience stomach upset while taking metformin, it’s important to talk with your healthcare provider. They can help you find ways to manage these side effects, like adjusting your dose or switching to a different form of the medicine.

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