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Published on: 9/24/2026
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What Are the Side Effects of mFLUSIVA?
mFLUSIVA is an inactivated influenza vaccine designed to trigger your immune system to protect against seasonal flu strains. Like all vaccines, mFLUSIVA can cause side effects as your body builds immunity. Understanding these reactions can help you know what to expect and when to seek medical care.
mFLUSIVA contains killed flu virus fragments. After injection, your immune system recognizes these fragments as foreign and learns to fight them. If you encounter the real flu virus later, your body can respond more quickly and prevent serious illness.
Most people tolerate mFLUSIVA well. Side effects tend to be mild to moderate and resolve within 1–3 days. Common reactions include:
• Injection‐site reactions
– Pain, redness or swelling where the vaccine was given
– Mild firmness or warmth under the skin
• Muscle aches
– Low‐grade muscle soreness, especially in the arm that received the shot
• Fatigue
– Feeling tired or run-down for a day or two
• Headache
– A mild to moderate headache
• Low-grade fever
– Temperature up to 100.4°F (38°C)
• Chills
– Brief chills or shivering
These reactions are signs your immune system is working. Applying a cool, damp cloth and taking over-the-counter pain relievers (acetaminophen or ibuprofen) can help.
A smaller number of people may experience:
• Joint pain
• Nausea or mild upset stomach
• Swollen lymph nodes (glands in the neck or armpit)
• Mild dizziness
• Itching at the injection site
These effects usually appear within 24 hours and resolve quickly. Staying hydrated, resting, and avoiding strenuous activity can ease discomfort.
Serious adverse events are very uncommon but can occur with any vaccine. You should be aware of:
• Severe allergic reaction (anaphylaxis)
– Symptoms: difficulty breathing, hives, swelling of the face or throat, rapid heartbeat
– Onset: usually within minutes to a few hours
• Guillain‐Barré Syndrome (GBS)
– A rare neurological disorder causing muscle weakness or paralysis
– Onset: within 6 weeks of vaccination (risk is extremely low)
• High fever (>104°F / 40°C)
– Especially in infants or those with certain medical conditions
• Seizures (febrile or non‐febrile)
– Most often related to high fever
If you notice any of these, seek medical attention immediately. Early treatment is critical.
Rest and hydrate
– Drink plenty of water, herbal tea, or clear broth.
– Avoid excessive physical exertion for 24–48 hours.
Apply a cool compress
– A damp washcloth over the injection site can reduce pain and swelling.
Use over-the-counter pain relievers
– Acetaminophen or ibuprofen can ease fever, headache, and muscle aches.
– Follow dosage instructions on the package.
Wear loose clothing
– A short-sleeve shirt or clothing that doesn’t rub the injection site helps reduce irritation.
Monitor your symptoms
– Keep track of any new or worsening reactions.
Most mFLUSIVA side effects are mild, but contact your doctor or head to urgent care if you experience:
• Symptoms lasting more than 3 days or getting worse
• Fever over 102°F (38.9°C) that doesn’t respond to medication
• Severe headache, neck stiffness or confusion
• Shortness of breath or chest pain
• Persistent vomiting or severe abdominal pain
• Signs of anaphylaxis (trouble breathing, swelling, hives)
If you’re ever unsure, it’s better to err on the side of caution.
You might consider doing a free, online symptom check, using the doctor approved Ubie Symptom Checker to get personalized guidance on whether you need to seek emergency care or can manage at home.
mFLUSIVA is an effective tool to help prevent seasonal flu. While side effects like soreness, fatigue and low-grade fever are common, they generally resolve quickly. Rarely, serious reactions can occur. Always keep an eye on your symptoms and don’t hesitate to speak to a doctor if you experience anything life-threatening or concerning. Your healthcare provider can offer advice tailored to your medical history and current health status.
(References)
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* Influenza vaccine for 2023-2024. Med Lett Drugs Ther. 2023 Oct 16;65(1687):161-166. doi: 10.58347/tml.2023.1687a. PMID: 37871115.
* Influenza vaccine for 2024-2025. Med Lett Drugs Ther. 2024 Sep 16;66(1711):145-150. doi: 10.58347/tml.2024.1711a. PMID: 39250341.
* Soens M, Ananworanich J, Hicks B, Lucas KJ, Cardona J, Sher L, Livermore G, Schaefers K, Henry C, Choi A, Avanesov A, Chen R, Du E, Pucci A, Das R, Miller J, Nachbagauer R. A phase 3 randomized safety and immunogenicity trial of mRNA-1010 seasonal influenza vaccine in adults. Vaccine. 2025 Mar 19;50:126847. doi: 10.1016/j.vaccine.2025.126847. Epub 2025 Feb 7. PMID: 39919447.
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