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Published on: 10/22/2026
Benzocaine teething gels are not recommended for babies because they can trigger methemoglobinemia, a rare but potentially life threatening condition that reduces the oxygen carried in a baby's blood, which is why the FDA has warned against using these products in children under 2 and asked manufacturers to stop marketing them for teething pain. Warning signs can appear within minutes to hours and include pale, gray or blue colored skin, lips or nail beds, shortness of breath, unusual fatigue, rapid heartbeat or irritability. Benzocaine also numbs the gag reflex and is quickly washed away by saliva, so the risk often outweighs the brief relief it may provide. Safer comfort measures, dosing concerns, and the symptoms that signal an emergency are explained below, along with details every caregiver should review before using any oral numbing product.
If your baby is fussy, drooling, or you are worried about a reaction to a teething product, it helps to get clarity fast rather than guessing. A free, instant, online symptom check walks you through targeted questions, highlights possible causes based on the specific signs you describe, and helps you judge whether home care is reasonable or whether this warrants urgent medical attention. It takes only a few minutes, requires no appointment, and can help you arrive at a doctor's visit with clearer information and better questions.
Last reviewed for medical accuracy: 10/22/2025
As a parent, you want the best relief for your baby’s teething discomfort. Over-the-counter gels—often containing benzocaine—seem like a quick fix. However, many health experts and the U.S. Food and Drug Administration (FDA) have raised serious concerns. Here’s what you need to know about the orajel benzocaine infant warning and safer teething alternatives.
In 2018, the FDA strengthened its warning about benzocaine gels for infants and young children:
The FDA now recommends against using benzocaine products in children younger than two years old, except under specific medical advice.
Immature Enzymes
Babies’ bodies are still developing the enzymes that break down medications. Benzocaine may linger longer and in higher levels than in adults.
Thin Oral Tissues
The delicate lining of a baby’s mouth absorbs topical agents more quickly, increasing systemic exposure.
Unpredictable Dosing
It’s easy to apply too much gel. Even a small extra amount can raise the risk of methemoglobinemia.
Early detection is vital. Look for:
If you suspect any of these signs, seek immediate medical attention.
Rather than benzocaine gels, consider these tried-and-true methods:
Chilled Teething Rings
Avoid freezing solid—icy hardness can hurt gums. A slightly chilled ring offers soothing pressure.
Clean, Wet Washcloth
Dampen and chill in the refrigerator. Soft texture and cool temperature help relieve pain.
Gentle Gum Massage
Wash your hands thoroughly, then use a clean finger to rub your baby’s gums. Mild pressure can soothe irritation.
Over-the-Counter Pain Reliever
Infant acetaminophen or ibuprofen (for babies over six months) can be used at recommended doses. Always follow dosing instructions or consult your pediatrician.
When you see labels or ads featuring “orajel benzocaine infant warning,” it reflects:
Teething discomfort peaks around six months but usually resolves by age three. Still, persistent or severe symptoms warrant medical advice:
You might also consider a free, online symptom check, using the doctor approved Ubie Symptom Checker if you’re unsure about the severity of your baby’s symptoms.
None of the information above replaces professional medical advice. Always:
Keeping your baby safe is your top priority. By avoiding benzocaine gels and opting for gentler methods, you can ease teething pain without the hidden dangers of methemoglobinemia. If you have any doubts or need tailored guidance, please speak to a doctor.
(References)
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* Khanal S, Modi R, Akhtar K, Ghimire A. Benzocaine-Associated Methemoglobinemia. Am J Ther. 2018 Nov/Dec;25(6):e771-e772. doi: 10.1097/MJT.0000000000000782. PMID: 29912717.
* Benzocaine. 2006. PMID: 30000812.
* Singh R, Patel P, Al Khalili Y. Benzocaine. 2024 Jan. PMID: 31082097.
* Warren OU, Blackwood B. Acquired Methemoglobinemia. N Engl J Med. 2019 Sep 19;381(12):1158. doi: 10.1056/NEJMicm1816026. PMID: 31532963.
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