Published on: 6/20/2025
What could be the underlying reasons for persistent fatigue?
Persistent fatigue can be caused by depression, neurological issues, or chronic kidney disease. Each condition affects the body differently, leading to feelings of tiredness that don't go away easily.
Explanation
Feeling tired all the time can have different causes. One reason could be major depression, where people feel very tired and sleepy during the day. If you or someone you know is struggling with mental health, it might help to visit 988lifeline.org.
Another reason might be neurological problems. These are issues with the brain or nerves that can make you feel sleepy and tired during the day. It's like your body and brain are not getting the rest they need.
Lastly, chronic kidney disease can also make you feel very tired. This happens because the kidneys are not working well, which affects how you feel overall. The body might not be able to get rid of waste and toxins properly, making you feel more tired.
If you're experiencing persistent fatigue, it might help to talk to a healthcare professional to find out the cause and get the right help.
(References)
- Baldwin DS, & Papakostas GI. (2006). Symptoms of fatigue and sleepiness in major depressive .... The Journal of clinical psychiatry, 16848671.
- Maestri M, Romigi A, Schirru A, Fabbrini M, Gori S, Bonuccelli U, & Bonanni E. (2020). Excessive daytime sleepiness and fatigue in neurological .... Sleep & breathing = Schlaf & Atmung, 31444679.
- Zalai D, & Bohra M. (2016). Fatigue in chronic kidney disease: Definition, assessment .... CANNT journal = Journal ACITN, 27215061.
Tell your friends about us.
We would love to help them too.
For First Time Users
What is Ubie’s Doctor’s Note?
We provide a database of explanations from real doctors on a range of medical topics. Get started by exploring our library of questions and topics you want to learn more about.
Learn more about diseases
Was this page helpful?
Purpose and positioning of servicesUbie Doctor's Note is a service for informational purposes. The provision of information by physicians, medical professionals, etc. is not a medical treatment. If medical treatment is required, please consult your doctor or medical institution. We strive to provide reliable and accurate information, but we do not guarantee the completeness of the content. If you find any errors in the information, please contact us.