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Published on: 11/26/2025
Can pramipexole help if REM Sleep Behavior Disorder (RBD) occurs with Parkinson's disease?
Pramipexole may help some people with REM Sleep Behavior Disorder (RBD) in Parkinson's disease, but its effectiveness varies, and more research is needed.
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Pramipexole is a medication sometimes used to treat symptoms of Parkinson's disease. There is some evidence suggesting it might help with REM Sleep Behavior Disorder (RBD), a condition where people act out their dreams during sleep.
- Reference 1 suggests that pramipexole could be helpful for RBD. However, this is not a definite conclusion, and the effects can vary between individuals.
- Reference 2 found that pramipexole did not significantly improve RBD symptoms, indicating that it may not be effective for everyone.
Therefore, while pramipexole might help some people with RBD, it is not guaranteed to work for everyone. More research is needed to fully understand its effects on RBD in people with Parkinson's disease. It's important to talk to a healthcare provider to explore all treatment options.
(References)
- Schmidt MH, Koshal VB, & Schmidt HS. (2006). Use of pramipexole in REM sleep behavior disorder. Sleep medicine, 16815751.
- Kumru H, Iranzo A, Carrasco E, Valldeoriola F, Marti MJ, Santamaria J, & Tolosa E. (2008). Lack of effects of pramipexole on REM sleep behavior .... Sleep, 18853939.
- During EH, Malkani R, Arnulf I, Kunz D, Bes F, De Cock VC, et al. (2025). Symptomatic treatment of REM sleep behavior disorder .... Sleep medicine, 40408791.
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