Doctors Note Logo

Published on: 9/29/2026

What Is Rhinovirus, and How Is It Different From Flu?

Rhinovirus is the most frequent cause of the common cold, typically producing a runny or stuffy nose, sneezing, sore throat, and mild cough that come on gradually and stay centered in the upper airway. Influenza, by contrast, is caused by influenza A or B viruses and usually arrives abruptly with fever, chills, body aches, headache, and pronounced fatigue, carrying a higher risk of complications such as pneumonia, especially in young children, older adults, and people with chronic conditions. Because symptoms overlap and timing, severity, and risk factors all matter, there are several important distinctions to weigh before deciding on rest, testing, or antiviral treatment, all explained below.

Since colds and flu can look nearly identical in the first 48 hours, when antiviral timing matters most, it helps to sort out what you are dealing with quickly. Take a free, instant, online symptom check to better understand your symptoms and get clear guidance on your next steps.

Last reviewed for medical accuracy: 09/29/2025

answer background

Explanation

What Is Rhinovirus?

Rhinovirus is one of the most common causes of the common cold. Every year, millions of people worldwide catch a cold due to rhinovirus infections. Understanding what rhinovirus is, how it spreads, and how it differs from the flu can help you manage symptoms, prevent transmission, and know when to seek medical care.

What Is Rhinovirus?

Rhinovirus belongs to a family of viruses called Picornaviridae. There are more than 100 different rhinovirus types, which is why you can catch colds over and over again.

Key features of rhinovirus:

  • Structure & Classification
    • Small, non-enveloped RNA virus
    • Three species: RV-A, RV-B, RV-C
  • Transmission
    • Spread via respiratory droplets (coughing, sneezing)
    • Direct contact with contaminated surfaces (doorknobs, phones)
  • Incubation Period
    • Symptoms typically appear 1–3 days after exposure
  • Seasonality
    • Most common in early fall and late spring but can occur year-round

Common Symptoms of Rhinovirus Infection

Rhinovirus infections usually cause mild to moderate upper respiratory symptoms. They can include:

  • Runny or stuffy nose
  • Sneezing
  • Sore or scratchy throat
  • Mild cough
  • Low-grade fever (more common in children)
  • Headache or mild body aches
  • Watery eyes

Symptoms typically peak around days 2–3 and resolve within 7–10 days. In some cases, a cough or nasal drainage can linger for up to two weeks.

What Is the Flu?

Influenza (the flu) is caused by influenza viruses, primarily types A and B in humans. While both the common cold and flu are respiratory infections, the flu generally leads to more severe illness.

Key features of the flu:

  • Virus Types
    • Influenza A (subtyped by surface proteins HA & NA)
    • Influenza B (no subtypes, but split into two lineages)
  • Transmission
    • Similar to rhinovirus: respiratory droplets and surface contact
  • Incubation Period
    • Typically 1–4 days after exposure
  • Seasonality
    • Peaks in late fall through early spring in temperate climates

Differences Between Rhinovirus and Flu

Though they both attack the respiratory tract, rhinovirus colds and influenza infections have distinct characteristics:

Feature Rhinovirus (Common Cold) Influenza (Flu)
Onset Gradual (over 1–2 days) Sudden (within hours)
Fever Rare or low-grade Common, often high (38°C/100.4°F+)
Body Aches Mild Moderate to severe
Fatigue Mild Moderate to severe
Nasal Congestion/Sneezing Prominent Can occur, but less prominent
Cough Mild to moderate Often severe
Duration 7–10 days (can linger longer) 5–7 days acute, but cough may linger
Complications Rare (middle ear infection, sinusitis) Common (pneumonia, bronchitis)

Onset and Severity

  • Cold (Rhinovirus): Symptoms build gradually, starting with a scratchy throat, then nasal congestion and sneezing.
  • Flu (Influenza): Symptoms come on quickly—one morning you feel fine, by the afternoon you’re feverish, achy, and exhausted.

Fever and Body Aches

  • Fevers above 38°C (100.4°F) are typical with the flu but uncommon with a rhinovirus cold.
  • Body aches and extreme fatigue are hallmarks of influenza, whereas colds tend to cause only mild discomfort.

Diagnosis

Both conditions are usually diagnosed based on symptoms and physical exam:

  • Medical History & Symptom Review
  • Physical Exam (listening to lungs, checking nasal passages)
  • Rapid Tests
    • Flu: rapid antigen tests available in clinics
    • Cold: rarely tested—diagnosis is clinical

If you’re unsure whether you have a cold or the flu, or if your symptoms worsen, consider a free, online symptom check, using the doctor approved Ubie Symptom Checker. It can guide you on next steps and whether you should seek medical attention.

Treatment

There is no cure for rhinovirus infections; treatment focuses on relieving symptoms. Influenza may be treated with antiviral medications, which can shorten illness if started early.

Rhinovirus (Common Cold)

  • Rest and hydration
  • Over-the-counter (OTC) relief:
    • Decongestants (e.g., pseudoephedrine)
    • Pain relievers/fever reducers (e.g., acetaminophen, ibuprofen)
    • Throat lozenges or sprays
  • Saline nasal sprays and humidifiers

Influenza (Flu)

  • Antiviral medications (prescribed by a doctor):
    • Oseltamivir (Tamiflu)
    • Zanamivir (Relenza)
    • Baloxavir marboxil (Xofluza)
  • Supportive care as for a cold: rest, fluids, OTC medications

Prevention

Preventing rhinovirus and flu infections relies on good hygiene and, for influenza, vaccination.

General Hygiene Measures

  • Wash hands often with soap and water for at least 20 seconds
  • Use alcohol-based hand sanitizer when soap isn’t available
  • Avoid touching your face (especially eyes, nose, and mouth)
  • Cover coughs and sneezes with a tissue or your elbow
  • Clean and disinfect frequently touched surfaces

Influenza Vaccination

  • Annual flu shot recommended for everyone aged 6 months and older
  • Vaccines are updated each year to match circulating flu strains
  • Reduces risk of severe illness, hospitalization, and complications

There is currently no vaccine for rhinovirus, mainly because of the large number of distinct types.

When to Seek Medical Care

Most colds and flu cases are self-limiting, but you should contact a healthcare provider if you experience:

  • Difficulty breathing or shortness of breath
  • Chest pain or pressure
  • Confusion or severe dizziness
  • Persistent high fever (especially above 39°C/102.2°F)
  • Severe or worsening cough
  • Signs of dehydration (little/no urination, dry mouth, dizziness)
  • Symptoms lasting more than 10 days without improvement

For mild to moderate symptoms, you might start with a free, online symptom check, using the doctor approved Ubie Symptom Checker. It can help you decide if you need to see a doctor or manage symptoms at home.

Key Takeaways

  • Rhinovirus causes the common cold: mild, gradual onset, mainly nasal symptoms.
  • Influenza causes more severe illness: sudden onset, high fever, body aches, possible complications.
  • Diagnosis is usually clinical; flu can be confirmed with rapid testing.
  • Treatment for a cold is symptomatic; flu may be treated with antivirals.
  • Prevention for both includes hand hygiene; flu prevention also includes vaccination.
  • Seek medical care if you have severe or worsening symptoms.

If you have any serious concerns—especially symptoms that could be life-threatening—please speak to a doctor right away. Your health and safety are the top priority.

(References)

  • * Semenov BF, Gervazieva VB, Sveranovskaia VV. [Prevalence and structure of acute respiratory virus infections]. Zh Mikrobiol Epidemiol Immunobiol. 2002 Sep-Oct;(5):79-86. PMID: 12525011.

  • * Kelly ML, Cook JA, Brown-Augsburger P, Heinz BA, Smith MC, Pinto LH. Demonstrating the intrinsic ion channel activity of virally encoded proteins. FEBS Lett. 2003 Sep 18;552(1):61-7. doi: 10.1016/s0014-5793(03)00851-2. PMID: 12972153.

  • * GHEZZO F, BARETTA G. COLDS AND THEIR VIRUSES. Br Med J. 1964 Feb 29;1(5382):513-4. doi: 10.1136/bmj.1.5382.513. PMID: 14101993; PMCID: PMC1813537.

  • * PORTNOY B, ECKERT HL, SALVATORE MA. RHINOVIRUS INFECTION IN CHILDREN WITH ACUTE LOWER RESPIRATORY DISEASE: EVIDENCE AGAINST ETIOLOGICAL IMPORTANCE. Pediatrics. 1965 Jun;35:899-905. PMID: 14296415.

  • * Spier RE. On the need for, and the delivery of, cross-protective vaccines. Vaccine. 2005 Mar 18;23(17-18):2027-9. doi: 10.1016/j.vaccine.2005.01.003. PMID: 15755565.

  • * Asner S, Peci A, Marchand-Austin A, Winter AL, Olsha R, Kristjanson E, Low DE, Gubbay JB. Respiratory viral infections in institutions from late stage of the first and second waves of pandemic influenza A (H1N1) 2009, Ontario, Canada. Influenza Other Respir Viruses. 2012 May;6(3):e11-5. doi: 10.1111/j.1750-2659.2012.00336.x. Epub 2012 Feb 21. PMID: 22353417; PMCID: PMC4941672.

  • * Etherington C, Naseer R, Conway SP, Whitaker P, Denton M, Peckham DG. The role of respiratory viruses in adult patients with cystic fibrosis receiving intravenous antibiotics for a pulmonary exacerbation. J Cyst Fibros. 2014 Jan;13(1):49-55. doi: 10.1016/j.jcf.2013.06.004. Epub 2013 Jul 23. PMID: 23891398.

  • * Du XB, Ma X, Gao Y, Wen LF, Li J, Wang ZZ, Liu S. [Prevalence and risk factors of respiratory viral infection in acute exacerbation of chronic obstructive pulmonary disease]. Zhonghua Jie He He Hu Xi Za Zhi. 2017 Apr 12;40(4):263-266. doi: 10.3760/cma.j.issn.1001-0939.2017.04.004. PMID: 28395404.

  • * Aminian M, Ghosh T, Peterson A, Rasmussen AL, Stiverson S, Sharma K, Kirby M. Early prognosis of respiratory virus shedding in humans. Sci Rep. 2021 Aug 25;11(1):17193. doi: 10.1038/s41598-021-95293-z. Epub 2021 Aug 25. PMID: 34433834; PMCID: PMC8387366.

  • * Davido B, Jaffal K, Gault E, Bourlet S, Beaune S. Back to the future of viruses: a case of triple coinfection caused by respiratory syncytial virus, human coronavirus OC43, and rhinovirus. Int J Infect Dis. 2023 May;130:205-207. doi: 10.1016/j.ijid.2023.03.024. Epub 2023 Mar 21. PMID: 36948447; PMCID: PMC10028211.

Thinking about asking ChatGPT?Ask me instead

Tell your friends about us.

We would love to help them too.

smily Shiba-inu looking

For First Time Users

What is Ubie’s Doctor’s Note?

We provide a database of explanations from real doctors on a range of medical topics. Get started by exploring our library of questions and topics you want to learn more about.

Was this page helpful?

Purpose and positioning of servicesUbie Doctor's Note is a service for informational purposes. The provision of information by physicians, medical professionals, etc. is not a medical treatment. If medical treatment is required, please consult your doctor or medical institution. We strive to provide reliable and accurate information, but we do not guarantee the completeness of the content. If you find any errors in the information, please contact us.