Published on: 3/5/2025
Seizures can sometimes lead to memory loss by affecting the way the brain records and stores memories. The memory issues may be temporary or last longer, depending on the individual and the type of seizure.
When a seizure occurs, the brain goes through sudden, unusual activity that can disrupt normal brain functions. This abnormal activity especially affects areas like the hippocampus, which plays a big role in making and storing memories. Because of this disruption, some people may have problems recalling things that happened before a seizure (a type of memory loss called retrograde amnesia) or forming new memories after the seizure (anterograde amnesia). Researchers have observed that memory changes can occur during active seizures, and sometimes the memory loss may even improve if the seizures stop or become less frequent. However, many factors, like how long the seizures last and which part of the brain is involved, can change how much memory is affected. In some cases, once the seizures are controlled, cognitive functions, including memory, may show improvement. This field continues to be an important area of research to understand how best to help people manage these changes in memory.
(References)
Novak A, Vizjak K, Rakusa M. Cognitive Impairment in People with Epilepsy. J Clin Med. 2022 Jan 5;11(1):267. doi: 10.3390/jcm11010267. PMID: 35012007; PMCID: PMC8746065.
Naik AA, Sun H, Williams CL, Weller DS, Julius Zhu J, Kapur J. Mechanism of seizure-induced retrograde amnesia. Prog Neurobiol. 2021 May;200:101984. doi: 10.1016/j.pneurobio.2020.101984. Epub 2020 Dec 31. PMID: 33388373; PMCID: PMC8026600.
Sekimoto M, Muramatsu R, Kato M, Onuma T. Clinical and neuropsychological changes after the disappearance of seizures in a case of transient epileptic amnesia. Epilepsy Behav Case Rep. 2017 Jan 29;7:54-57. doi: 10.1016/j.ebcr.2017.01.002. PMID: 28409114; PMCID: PMC5379913.
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