Doctors Note Logo

Published on: 7/15/2026

What other diseases have symptoms similar to hand, foot, and mouth disease?

Hand, foot, and mouth disease (HFMD) shares symptoms with several other illnesses, which can make diagnosis tricky. Conditions that commonly mimic HFMD include:

  • Herpangina – causes painful mouth sores but typically without the hand and foot rash
  • Chickenpox – produces widespread itchy blisters across the body
  • Measles – begins with fever, cough, and a spreading rash
  • Viral exanthems – various viral infections that cause skin rashes resembling HFMD

Because these conditions require different treatments and carry different risks, accurate identification is essential for proper care and recovery.

If you or your child are experiencing symptoms that could point to HFMD or one of these look-alike conditions, don't guess. Take a free, instant, online symptom check to better understand what may be causing your symptoms and get clear guidance on your next steps. It only takes a few minutes and could help you make more informed decisions about seeking care.

Reviewed for medical accuracy: 07/14/2026

answer background

Explanation

Understanding Hand, Foot, and Mouth Disease

HFMD is a common viral infection primarily affecting young children, characterized by fever, mouth sores, and a rash on the hands and feet. The disease is usually caused by enteroviruses, particularly coxsackievirus.

Diseases with Similar Symptoms

Several other diseases can present with symptoms similar to those of HFMD:

  • Herpangina: This condition is also caused by coxsackievirus and presents with fever and painful sores in the mouth, particularly on the soft palate and tonsils. Unlike HFMD, herpangina does not typically cause a rash on the hands and feet.
  • Chickenpox: Caused by the varicella-zoster virus, chickenpox presents with a characteristic itchy rash that progresses from red spots to fluid-filled blisters. While it can cause fever and malaise, the rash distribution is different from HFMD, as it usually covers the entire body rather than being localized to the hands and feet.
  • Measles: This viral infection is characterized by a high fever, cough, runny nose, and a distinctive rash that starts on the face and spreads downward. Measles can also cause Koplik spots (small white spots) in the mouth, which can be confused with the sores seen in HFMD.
  • Other Viral Exanthems: Various viral infections can cause rashes and systemic symptoms similar to HFMD. These include rubella (German measles) and roseola, which can present with fever and rash but have different patterns and associated symptoms.

Importance of Accurate Diagnosis

Given the overlap in symptoms, it is crucial for healthcare providers to differentiate HFMD from these other conditions. If you're experiencing symptoms like fever, mouth sores, or a rash, taking a free symptom checker test can help you understand what might be causing your discomfort and whether you should seek medical attention. Accurate diagnosis is important for:

  • Management: While HFMD is usually self-limiting and requires supportive care, other conditions may require different management strategies or interventions.
  • Prevention: Some diseases, like measles and chickenpox, are preventable through vaccination, making awareness of symptoms important for public health.

(References)

  • Saguil A, Kane SF, Lauters R, Mercado MG. Hand-Foot-and-Mouth Disease: Rapid Evidence Review. Am Fam Physician. 2019 Oct 1;100(7):408-414. PMID: 31573162.

Thinking about asking ChatGPT?Ask me instead

Tell your friends about us.

We would love to help them too.

smily Shiba-inu looking

For First Time Users

What is Ubie’s Doctor’s Note?

We provide a database of explanations from real doctors on a range of medical topics. Get started by exploring our library of questions and topics you want to learn more about.

Was this page helpful?

Purpose and positioning of servicesUbie Doctor's Note is a service for informational purposes. The provision of information by physicians, medical professionals, etc. is not a medical treatment. If medical treatment is required, please consult your doctor or medical institution. We strive to provide reliable and accurate information, but we do not guarantee the completeness of the content. If you find any errors in the information, please contact us.