Our Services
Medical Information
Helpful Resources
Published on: 9/24/2026
A wide gap between the top and bottom numbers, known as high pulse pressure, most often reflects stiffening of the large arteries from aging, long-standing high blood pressure, or atherosclerosis. Other causes include aortic valve regurgitation, an overactive thyroid, severe anemia, fever or sepsis, pregnancy, and certain medications or nutrient deficiencies such as low iron. A reading with a difference greater than about 60 mmHg, or a gap that keeps widening over time, is linked to higher risk of heart attack, stroke, and kidney problems, so the underlying cause matters as much as the number itself. There are several important factors to consider, including how the reading was taken and which symptoms accompany it, so see below to understand more.
If your numbers look unusual and you are unsure whether it signals stiff arteries, a valve issue, or something more treatable, a free, instant, online symptom check can help you organize your symptoms, see which conditions fit your pattern, and decide whether to monitor at home or arrange prompt medical evaluation.
Last reviewed for medical accuracy: 09/24/2026
Blood pressure measures the force of blood pushing against the walls of your arteries. It’s recorded as two numbers:
A typical reading is around 120/80 mm Hg. The difference between these two numbers is called the pulse pressure. When that gap widens—say your readings are 160/60 mm Hg (a pulse pressure of 100)—it can signal underlying issues.
Pulse pressure = systolic – diastolic
Understanding why pulse pressure widens helps you and your doctor pinpoint potential causes and manage any risks.
A wide gap between systolic and diastolic readings can result from several factors:
• Aging and Arterial Stiffness
• Aortic Valve Regurgitation
• Hyperthyroidism
• Anemia
• Fever or Infection
• Arteriovenous (AV) Fistula
• Paget’s Disease of Bone
• High Cardiac Output States
A persistently wide pulse pressure can mean:
While a single wide reading might be harmless—especially during exercise or excitement—consistent readings should prompt action:
If you’re worried or experiencing symptoms, consider a free, online symptom check, using the doctor approved Ubie Symptom Checker. It can help you decide if you need urgent care or a routine appointment.
Your doctor may recommend:
Treatment targets the underlying cause and may involve:
• Lifestyle changes
• Medications
• Treating specific conditions
It’s natural to feel concerned about blood pressure changes. Remember:
A wide gap between your systolic and diastolic blood pressure readings—known as wide pulse pressure—can signal various health issues, from natural aging to valve problems or systemic conditions. Keeping track of your blood pressure, understanding potential causes, and working with your doctor are key steps to protect your heart and overall health.
If you’re unsure about your readings or experiencing symptoms, don’t hesitate to speak to a doctor. Your healthcare provider can guide you through appropriate tests, treatments, and lifestyle adjustments to bring your systolic diastolic blood pressure measurements back into a healthy range.
(References)
* Rizzo V, di Maio F, Petretto F, Marziali M, Bianco G, Barilla F, Paravati V, Pignata D, Campbell SV, Donato G, Bernardo V, Tallarico D. Ambulatory pulse pressure, left ventricular hypertrophy and function in arterial hypertension. Echocardiography. 2004 Jan;21(1):11-6. doi: 10.1111/j.0742-2822.2004.02146.x. PMID: 14717715.
* Rimoldi SF, Yuzefpolskaya M, Allemann Y, Messerli F. Flash pulmonary edema. Prog Cardiovasc Dis. 2009 Nov-Dec;52(3):249-59. doi: 10.1016/j.pcad.2009.10.002. PMID: 19917337.
* Andrade J, Khairy P, Dobrev D, Nattel S. The clinical profile and pathophysiology of atrial fibrillation: relationships among clinical features, epidemiology, and mechanisms. Circ Res. 2014 Apr 25;114(9):1453-68. doi: 10.1161/CIRCRESAHA.114.303211. PMID: 24763464.
* Liu D, Qin P, Liu L, Liu Y, Sun X, Li H, Zhao Y, Zhou Q, Li Q, Guo C, Tian G, Wu X, Han M, Qie R, Huang S, Zhang M, Hu D, Lu J. Association of pulse pressure with all-cause and cause-specific mortality. J Hum Hypertens. 2021 Mar;35(3):274-279. doi: 10.1038/s41371-020-0333-5. Epub 2020 Apr 7. PMID: 32265487.
* Tsai TY, Cheng HM, Chuang SY, Chia YC, Soenarta AA, Minh HV, Siddique S, Turana Y, Tay JC, Kario K, Chen CH. Isolated systolic hypertension in Asia. J Clin Hypertens (Greenwich). 2021 Mar;23(3):467-474. doi: 10.1111/jch.14111. Epub 2020 Nov 29. PMID: 33249701; PMCID: PMC8029528.
* Papadakis JA, Ioannou P, Theodorakopoulou V, Papanikolaou K, Vrentzos G. Metabolic profile of patients with isolated systolic hypertension. Hormones (Athens). 2021 Jun;20(2):377-380. doi: 10.1007/s42000-020-00266-y. Epub 2021 Jan 6. PMID: 33409906.
* Saladini F. Isolated systolic hypertension in the young: a heterogeneous condition. Minerva Med. 2022 Oct;113(5):769-778. doi: 10.23736/S0026-4806.21.07627-8. Epub 2021 May 14. PMID: 33988016.
* D'Elia L, Strazzullo P. Isolated systolic hypertension of the young and sodium intake. Minerva Med. 2022 Oct;113(5):788-797. doi: 10.23736/S0026-4806.21.07740-5. Epub 2021 Sep 29. PMID: 34586768.
* Yazdani B, Kleber ME, Yücel G, Delgado GE, Husain-Syed F, Krüger B, März W, Schwenke K, Sigl M, Krämer BK. Polyvascular disease, pulse pressure and mortality. Vasa. 2022 Jul;51(4):229-238. doi: 10.1024/0301-1526/a001011. Epub 2022 May 23. PMID: 35603601.
* Benas D, Triantafyllidi H, Birmpa D, Fambri A, Schoinas A, Thymis I, Kostelli G, Ikonomidis I. Hypertension-Mediated Organ Damage In Young Patients With First-Diagnosed And Never Treated Systolic Hypertension. Curr Vasc Pharmacol. 2023;21(3):197-204. doi: 10.2174/1570161121666230531153431. PMID: 37533181.
We would love to help them too.
For First Time Users
We provide a database of explanations from real doctors on a range of medical topics. Get started by exploring our library of questions and topics you want to learn more about.
Was this page helpful?
Purpose and positioning of servicesUbie Doctor's Note is a service for informational purposes. The provision of information by physicians, medical professionals, etc. is not a medical treatment. If medical treatment is required, please consult your doctor or medical institution. We strive to provide reliable and accurate information, but we do not guarantee the completeness of the content. If you find any errors in the information, please contact us.