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Published on: 10/1/2026
Tessalon Perles (benzonatate) are prescription, non-narcotic capsules used to relieve a dry, hacking cough by numbing the stretch receptors in the lungs and airways, usually taking effect within 15 to 20 minutes. Adults and children over 10 typically take one 100 mg or 200 mg capsule up to three times a day, never exceeding 600 mg in 24 hours, and each capsule must be swallowed whole, since chewing, sucking, or breaking it can cause numbness of the mouth and throat, choking, or a severe reaction. There are several other important factors to consider, including side effects, interactions, overdose risks in young children, and when a cough signals something more serious, so review the complete details below.
Because a lingering cough can stem from allergies, acid reflux, asthma, a virus, or a lung condition that a cough suppressant will not fix, it helps to understand the cause before you treat the symptom. Take a free, instant, online symptom check to see what may be driving your cough and get clear guidance on the right next steps.
Last reviewed for medical accuracy: 10/01/2026
Tessalon Pearls: What They Treat and How to Take Them
Tessalon Pearls (generic name: benzonatate) are prescription capsules used to relieve cough. They work by numbing the stretch receptors in your lungs and airways, reducing the urge to cough. Below is a clear, detailed guide on what tessalon pearls treat, how to take them, important precautions, side effects, and when to seek medical help.
How they work:
Tessalon Pearls are prescribed for:
They are not intended for productive (wet) coughs where mucus needs to be cleared. Always follow your doctor’s advice on whether tessalon pearls are right for you.
Follow these instructions carefully to ensure safe and effective cough relief:
Check Your Prescription
Swallow Whole
With or Without Food
Spacing Doses
Missed Dose
Storage
Before you start tessalon pearls, discuss these points with your doctor:
Most people tolerate tessalon pearls well, but be aware of:
Common side effects:
Less common but serious (seek help immediately):
If you experience any serious side effects, stop taking tessalon pearls and seek medical attention right away.
Tell your doctor about all medications and supplements you take. Notable interactions include:
Tessalon Pearls can improve uncomfortable coughs, but certain situations call for prompt professional care:
If you’re unsure what’s causing your cough or have other symptoms, consider a free, online symptom check, using the doctor approved Ubie Symptom Checker. This tool can help guide you on whether you need in-person care.
Alongside taking tessalon pearls, you can try:
Avoid smoking or exposure to second-hand smoke, which can worsen coughs.
Tessalon Pearls offer effective relief for dry, irritating coughs. They’re easy to take when you follow the “swallow whole” rule and watch for side effects. However, no online guide replaces personalized medical advice.
If you have a serious, life-threatening symptom—or if you’re pregnant, breastfeeding, or caring for a child—always speak to a doctor before starting or stopping any medication. If you suspect an emergency, call 911 or go to your nearest emergency department.
Your health matters. When in doubt about your cough or any other symptom, don’t hesitate to speak with a healthcare professional.
(References)
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* Yuizono T. [On the site of antitussive actions of ethyldibunate, benzonatate and (--)-methylephedrine]. Yakugaku Zasshi. 1967 Aug;87(8):923-34. doi: 10.1248/yakushi1947.87.8_923. PMID: 5625840.
* Tóth Z, Szauder S. [On the preparation of aqueous Benzonatate-injection]. Acta Pharm Hung. 1967 Jan;37(1):25-9. PMID: 6063066.
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* HUSEN JH. [Experiences with cough medicine tessalon]. Tuberkulosearzt. 1958 Apr;12(4):248-53. PMID: 13556996.
* NEW AND non-official drugs: benzonatate. J Am Med Assoc. 1959 Aug 15;170(16):1927-8. PMID: 13672794.
* CATTANEO AD. [Experiences with tessalon in peroral endoscopy]. Minerva Anestesiol. 1959 Sep;25:373-5. PMID: 13808447.
* LANGREHR D. [On the problem of receptor specificity of endoanesthetic effects based on the example of benzononatin (Tessalon)]. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1963;245:427-39. PMID: 13928673.
* Hendershot AJ, Colling L, Mauger TF. Corneal anesthetic abuse from the use of topical benzonatate (Tessalon Perle). Cornea. 2011 Dec;30(12):1518-9. doi: 10.1097/ICO.0b013e318207f229. PMID: 21673569.
* Billington M, Furmaga J, Schaeffer T. Arrhythmogenic Antitussive: A Case of Pediatric Benzonatate Overdose With Torsades de Pointes, Cardiac Arrest, and Complete Recovery Without Neurologic Deficits. J Pediatr Pharmacol Ther. 2020;25(7):642-646. doi: 10.5863/1551-6776-25.7.642. PMID: 33041720; PMCID: PMC7541021.
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