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Published on: 10/1/2026

Tessalon Perles: what they treat and how to take them

Tessalon Perles (benzonatate) are prescription, non-narcotic capsules used to relieve a dry, hacking cough by numbing the stretch receptors in the lungs and airways, usually taking effect within 15 to 20 minutes. Adults and children over 10 typically take one 100 mg or 200 mg capsule up to three times a day, never exceeding 600 mg in 24 hours, and each capsule must be swallowed whole, since chewing, sucking, or breaking it can cause numbness of the mouth and throat, choking, or a severe reaction. There are several other important factors to consider, including side effects, interactions, overdose risks in young children, and when a cough signals something more serious, so review the complete details below.

Because a lingering cough can stem from allergies, acid reflux, asthma, a virus, or a lung condition that a cough suppressant will not fix, it helps to understand the cause before you treat the symptom. Take a free, instant, online symptom check to see what may be driving your cough and get clear guidance on the right next steps.

Last reviewed for medical accuracy: 10/01/2026

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Explanation

Tessalon Pearls: What They Treat and How to Take Them

Tessalon Pearls (generic name: benzonatate) are prescription capsules used to relieve cough. They work by numbing the stretch receptors in your lungs and airways, reducing the urge to cough. Below is a clear, detailed guide on what tessalon pearls treat, how to take them, important precautions, side effects, and when to seek medical help.


What Are Tessalon Pearls?

  • Brand name: Tessalon Pearls
  • Generic: benzonatate
  • Dosage form: smooth, soft gelatin capsules (“pearls”) containing 100 mg or 200 mg of benzonatate

How they work:

  • Benzonatate is a non-narcotic cough suppressant.
  • It numbs the respiratory stretch receptors, interrupting the cough reflex.

What Do Tessalon Pearls Treat?

Tessalon Pearls are prescribed for:

  • Nonproductive (dry) coughs due to colds
  • Coughs from bronchitis, pneumonia, or other respiratory infections
  • Persistent coughing that disrupts sleep or daily activities

They are not intended for productive (wet) coughs where mucus needs to be cleared. Always follow your doctor’s advice on whether tessalon pearls are right for you.


How to Take Tessalon Pearls

Follow these instructions carefully to ensure safe and effective cough relief:

  1. Check Your Prescription

    • Typical adult dose: 100 mg to 200 mg taken three times a day as needed.
    • Do not exceed 600 mg in 24 hours.
    • Children under 10 years: usually not recommended.
  2. Swallow Whole

    • Do not chew, crush, or dissolve the pearl.
    • Chewing can release too much medicine at once, causing a numbing effect in the mouth or throat and risk of choking.
  3. With or Without Food

    • You can take tessalon pearls with water, with or without food.
    • If stomach upset occurs, take with food or milk.
  4. Spacing Doses

    • Space doses evenly; for example, morning, afternoon, and evening.
    • Only take when you actually have a cough—there’s no benefit to taking it “just in case.”
  5. Missed Dose

    • Take as soon as you remember if your next dose isn’t due soon.
    • If it’s almost time for your next dose, skip the missed one.
    • Do not double up.
  6. Storage

    • Keep at room temperature, away from moisture and heat.
    • Store out of reach of children—one capsule can be fatal if swallowed by a child.

Important Precautions

Before you start tessalon pearls, discuss these points with your doctor:

  • Allergies: Tell your doctor if you’re allergic to benzonatate, tetracaine, lidocaine, or other anesthetics.
  • Medical Conditions: Share any history of lung disease, chronic cough (e.g., from smoking), heart problems, or mental/mood disorders.
  • Pregnancy & Breastfeeding: Limited data exist. Only use if clearly needed and prescribed by your doctor.
  • Children: Tessalon Pearls are not approved for children under 10 years. Even one capsule in a child can cause serious harm.
  • Elderly: They may be more sensitive to side effects like dizziness or confusion.

Possible Side Effects

Most people tolerate tessalon pearls well, but be aware of:

Common side effects:

  • Drowsiness or dizziness
  • Nausea or upset stomach
  • Headache
  • Constipation

Less common but serious (seek help immediately):

  • Numbness of mouth, throat, or tongue
  • Mental confusion or hallucinations
  • Difficulty breathing or rapid heartbeat
  • Rash, itching, or swelling of face, lips, tongue, or throat
  • Seizures

If you experience any serious side effects, stop taking tessalon pearls and seek medical attention right away.


Drug Interactions

Tell your doctor about all medications and supplements you take. Notable interactions include:

  • Central nervous system depressants (e.g., alcohol, opioids, sedatives): may increase drowsiness or dizziness.
  • Other cough suppressants: avoid taking two medicines that suppress cough at once.
  • Antihypertensives or antidepressants: generally low risk, but always confirm with your doctor.

When to Seek Medical Attention

Tessalon Pearls can improve uncomfortable coughs, but certain situations call for prompt professional care:

  • Cough lasting more than 7 days, recurring, or accompanied by high fever
  • Cough producing blood or green/yellow phlegm
  • Severe shortness of breath or chest pain
  • Signs of a serious allergic reaction
  • Any sudden or worsening symptoms

If you’re unsure what’s causing your cough or have other symptoms, consider a free, online symptom check, using the doctor approved Ubie Symptom Checker. This tool can help guide you on whether you need in-person care.


Tips for Better Cough Management

Alongside taking tessalon pearls, you can try:

  • Staying hydrated: warm teas or water can soothe your throat.
  • Using a humidifier: adding moisture to the air can ease coughing.
  • Resting your voice: talk less if your throat is raw.
  • Elevating your head at night: reduces post-nasal drip.

Avoid smoking or exposure to second-hand smoke, which can worsen coughs.


Final Thoughts and Doctor Consultation

Tessalon Pearls offer effective relief for dry, irritating coughs. They’re easy to take when you follow the “swallow whole” rule and watch for side effects. However, no online guide replaces personalized medical advice.

If you have a serious, life-threatening symptom—or if you’re pregnant, breastfeeding, or caring for a child—always speak to a doctor before starting or stopping any medication. If you suspect an emergency, call 911 or go to your nearest emergency department.

Your health matters. When in doubt about your cough or any other symptom, don’t hesitate to speak with a healthcare professional.

(References)

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  • * Yuizono T. [On the site of antitussive actions of ethyldibunate, benzonatate and (--)-methylephedrine]. Yakugaku Zasshi. 1967 Aug;87(8):923-34. doi: 10.1248/yakushi1947.87.8_923. PMID: 5625840.

  • * Tóth Z, Szauder S. [On the preparation of aqueous Benzonatate-injection]. Acta Pharm Hung. 1967 Jan;37(1):25-9. PMID: 6063066.

  • * HERZOG H. [Polyethyleneglycol derivatives with antitussive effects, especially tessalon]. Schweiz Med Wochenschr. 1956 Jan 28;86(4):96-9. PMID: 13311426.

  • * HUSEN JH. [Experiences with cough medicine tessalon]. Tuberkulosearzt. 1958 Apr;12(4):248-53. PMID: 13556996.

  • * NEW AND non-official drugs: benzonatate. J Am Med Assoc. 1959 Aug 15;170(16):1927-8. PMID: 13672794.

  • * CATTANEO AD. [Experiences with tessalon in peroral endoscopy]. Minerva Anestesiol. 1959 Sep;25:373-5. PMID: 13808447.

  • * LANGREHR D. [On the problem of receptor specificity of endoanesthetic effects based on the example of benzononatin (Tessalon)]. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1963;245:427-39. PMID: 13928673.

  • * Hendershot AJ, Colling L, Mauger TF. Corneal anesthetic abuse from the use of topical benzonatate (Tessalon Perle). Cornea. 2011 Dec;30(12):1518-9. doi: 10.1097/ICO.0b013e318207f229. PMID: 21673569.

  • * Billington M, Furmaga J, Schaeffer T. Arrhythmogenic Antitussive: A Case of Pediatric Benzonatate Overdose With Torsades de Pointes, Cardiac Arrest, and Complete Recovery Without Neurologic Deficits. J Pediatr Pharmacol Ther. 2020;25(7):642-646. doi: 10.5863/1551-6776-25.7.642. PMID: 33041720; PMCID: PMC7541021.

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