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Published on: 10/14/2026

Tongkat ali side effects, and what it does to testosterone

Tongkat ali (Eurycoma longifolia) may modestly raise testosterone in men with low baseline levels, mainly by lowering cortisol and freeing testosterone bound to SHBG, though results vary and are strongest in stressed or older adults. Reported side effects include insomnia, restlessness, irritability, headache, nausea, and in rare cases elevated liver enzymes or mercury contamination in poorly sourced products. It can also interact with blood pressure, diabetes, and hormone-sensitive conditions, and is not advised during pregnancy or breastfeeding. Dosage, extract quality, and how long you take it all change your risk profile, and there are several important factors to consider before starting. See below to understand more about safe dosing, who should avoid it, and what the research actually shows.

If you are dealing with low energy, low libido, mood changes, or symptoms you hoped a supplement would fix, it is worth finding out what is actually driving them before adding something new. Low testosterone symptoms overlap heavily with thyroid issues, sleep apnea, depression, anemia, and medication side effects, and a supplement will not help any of those. A free, instant, online symptom check takes just a few minutes, asks the kinds of questions a clinician would, and gives you a clearer picture of possible causes. That means you can walk into an appointment knowing what to ask for, which tests to request, and whether tongkat ali is even relevant to your situation.

Last reviewed for medical accuracy: 10/13/2025

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Explanation

Understanding Tongkat Ali and Its Impact on Testosterone

Tongkat ali, also known as Eurycoma longifolia or “longjack,” is a traditional herbal supplement derived from the roots of a Southeast Asian plant. It’s commonly used to support male reproductive health, enhance athletic performance, and boost general well-being. One of its most talked-about benefits is its potential to raise testosterone levels. However, like any supplement, it can come with side effects and safety considerations.

Below, we’ll explore what tongkat ali does for testosterone, detail the known tongkat ali side effects, and offer practical advice on safe use. We’ll also suggest a free, online symptom check, using the doctor approved Ubie Symptom Checker. At the end, you’ll find guidance on when to speak to a healthcare professional.


How Tongkat Ali Affects Testosterone

Several human and animal studies suggest that tongkat ali may influence testosterone production and related pathways. While more large-scale trials are needed, the available research highlights a few key mechanisms:

  1. Stimulating the Leydig Cells

    • Leydig cells in the testes are responsible for producing testosterone.
    • Compounds called quassinoids in tongkat ali appear to support Leydig cell function, helping normalize testosterone levels.
  2. Reducing Sex Hormone–Binding Globulin (SHBG)

    • SHBG binds free testosterone, making it unavailable for the body to use.
    • Some studies indicate tongkat ali lowers SHBG levels, freeing up more active testosterone.
  3. Modulating the Hypothalamic–Pituitary–Gonadal (HPG) Axis

    • The HPG axis is the hormonal chain that signals testosterone production.
    • Animal data show tongkat ali may enhance gonadotropin-releasing hormone (GnRH) release, indirectly boosting luteinizing hormone (LH) and testosterone.
  4. Stress Hormone Balance

    • High cortisol (the stress hormone) can suppress testosterone.
    • Tongkat ali has adaptogenic properties—helping the body manage stress—and may lower cortisol, creating a more favorable environment for testosterone.

Research Highlights

  • A randomized, placebo-controlled trial in aging men (25–65 years) found a 14–18% increase in salivary testosterone after 12 weeks of tongkat ali supplementation.
  • Men with moderate stress who took tongkat ali reported improved mood and libido, with testosterone levels rising alongside reduced cortisol.
  • Bodybuilders and athletes using tongkat ali experienced modest strength gains and body composition improvements, likely linked in part to higher testosterone.

Tongkat Ali Side Effects

Although tongkat ali is generally well tolerated, some individuals may experience unwanted effects. Understanding these tongkat ali side effects can help you make an informed choice and recognize when to seek medical advice.

Common, Mild Side Effects

  • Insomnia or Restlessness
    Some users report difficulty sleeping, especially when taking higher doses or late in the day.
  • Increased Aggression or Mood Swings
    Testosterone surges can occasionally lead to irritability or heightened aggression.
  • Headaches
    Mild headaches may occur, possibly related to changes in hormone levels.
  • Stomach Upset
    Nausea, bloating, or diarrhea can appear, particularly on an empty stomach.

Less Common, Potentially Serious Side Effects

  • Elevated Heart Rate or Palpitations
    If you notice your heart racing, it could signal overstimulation of the nervous system.
  • High Blood Pressure
    In rare cases, tongkat ali’s stimulant-like effects may raise blood pressure.
  • Hormonal Imbalances
    Overuse can lead to excessively high testosterone, which may trigger acne, hair loss or prostate enlargement.
  • Allergic Reactions
    Skin rash, itching, or swelling could indicate an allergy to plant compounds.

Who May Be at Higher Risk?

  • Individuals with pre-existing heart conditions
  • People on blood pressure medications
  • Those with hormone-sensitive cancers (e.g., prostate or breast cancer)
  • Women who are pregnant or breastfeeding
  • Anyone under 18 years old

Safe Usage and Dosage Recommendations

  1. Start Low and Go Slow

    • Begin with half the recommended dose for 1–2 weeks.
    • If well tolerated, increase to the standard dose.
  2. Typical Dosages

    • 200–400 mg per day of a standardized extract (containing >1% eurycomanone) is common in studies.
    • Cycle on for 5 days, off for 2 days, or take 8–12 weeks on followed by a 2–4 week break.
  3. Timing

    • Take in the morning with food to reduce insomnia risk.
    • Avoid late-evening doses unless you find it does not disrupt sleep.
  4. Quality Matters

    • Choose products with third-party testing for purity and potency.
    • Avoid extracts with fillers, heavy metals or unknown additives.
  5. Monitor Your Body

    • Track mood, sleep quality, blood pressure and any unusual symptoms.
    • Use a free, online symptom check, using the doctor approved Ubie Symptom Checker if you notice anything concerning.

Practical Tips for Minimizing Risks

  • Stay Hydrated: Adequate water can help flush out excess hormones and reduce headaches.
  • Balance Nutrition: Eat a varied diet rich in zinc, magnesium and healthy fats to support natural hormone production.
  • Manage Stress: Combine tongkat ali with stress-reduction techniques (e.g., yoga, meditation) to optimize cortisol control.
  • Avoid Stimulants: Limit coffee and energy drinks, especially if you notice jitteriness or high blood pressure.
  • Record Your Results: Keep a simple journal of dose, timing, side effects and perceived benefits.

When to Seek Medical Advice

Though tongkat ali side effects are usually mild, certain signs warrant prompt attention:

  • Chest pain, shortness of breath or lightheadedness
  • Rapid or irregular heartbeat
  • Severe headache that doesn’t improve with rest or hydration
  • Persistent nausea, vomiting or diarrhea
  • Signs of an allergic reaction: rash, swelling of face or throat
  • Sudden mood swings or behavioral changes raising safety concerns

If you experience any life-threatening or serious symptoms, stop using tongkat ali immediately and speak to a doctor without delay. For non-urgent questions, consider a free, online symptom check, using the doctor approved Ubie Symptom Checker to help clarify your next steps.


Final Thoughts

Tongkat ali offers a promising, plant-based way to support healthy testosterone levels, stress balance and male vitality. While most people tolerate it well, be aware of tongkat ali side effects—particularly mood changes, sleep disturbances and cardiovascular signs. Always start with a low dose, choose a reputable brand and monitor your body closely.

For personalized guidance, discuss tongkat ali use with your healthcare provider. And remember, if you ever face serious or worrying symptoms, seek medical help right away. Your health is paramount—staying informed and cautious ensures you enjoy the benefits safely.

(References)

  • * Bhat R, Karim AA. Tongkat Ali (Eurycoma longifolia Jack): a review on its ethnobotany and pharmacological importance. Fitoterapia. 2010 Oct;81(7):669-79. doi: 10.1016/j.fitote.2010.04.006. Epub 2010 Apr 29. PMID: 20434529.

  • * Balasubramanian A, Thirumavalavan N, Srivatsav A, Yu J, Hotaling JM, Lipshultz LI, Pastuszak AW. An Analysis of Popular Online Erectile Dysfunction Supplements. J Sex Med. 2019 Jun;16(6):843-852. doi: 10.1016/j.jsxm.2019.03.269. Epub 2019 Apr 26. PMID: 31036522; PMCID: PMC9555224.

  • * Ahmad N, Teh BP, Halim SZ, Zolkifli NA, Ramli N, Muhammad H. Eurycoma longifolia-Infused Coffee-An Oral Toxicity Study. Nutrients. 2020 Oct 13;12(10). doi: 10.3390/nu12103125. Epub 2020 Oct 13. PMID: 33066137; PMCID: PMC7601993.

  • * Anand Ganapathy A, Hari Priya VM, Kumaran A. Medicinal plants as a potential source of Phosphodiesterase-5 inhibitors: A review. J Ethnopharmacol. 2021 Mar 1;267:113536. doi: 10.1016/j.jep.2020.113536. Epub 2020 Nov 1. PMID: 33137431.

  • * Leitão AE, Vieira MCS, Pelegrini A, da Silva EL, Guimarães ACA. A 6-month, double-blind, placebo-controlled, randomized trial to evaluate the effect of Eurycoma longifolia (Tongkat Ali) and concurrent training on erectile function and testosterone levels in androgen deficiency of aging males (ADAM). Maturitas. 2021 Mar;145:78-85. doi: 10.1016/j.maturitas.2020.12.002. Epub 2020 Dec 10. PMID: 33541567.

  • * Leisegang K, Finelli R, Sikka SC, Panner Selvam MK. Eurycoma longifolia (Jack) Improves Serum Total Testosterone in Men: A Systematic Review and Meta-Analysis of Clinical Trials. Medicina (Kaunas). 2022 Aug 4;58(8). doi: 10.3390/medicina58081047. Epub 2022 Aug 4. PMID: 36013514; PMCID: PMC9415500.

  • * Morgado A, Tsampoukas G, Sokolakis I, Schoentgen N, Urkmez A, Sarikaya S. Do "testosterone boosters" really increase serum total testosterone? A systematic review. Int J Impot Res. 2024 Jun;36(4):348-364. doi: 10.1038/s41443-023-00763-9. Epub 2023 Sep 11. PMID: 37697053.

  • * Tongkat Ali. 2012. PMID: 39527684.

  • * Zhang Z, Shi X, Wu T, He Z, Liang R, Ye W, Wu Z, Liao H, Zheng F, Yang Q, Zhao Z, Chen Y, Gao Z, Wang S, Wang M, Wang Z, Qi D, Yang M, Xu S, Wang Y, Zhao T, Egea J, Liu X, Pang J, Yi F, Zhan P. Discovery of multi-target anti-gout agents from Eurycoma longifolia Jack through phenotypic screening and structural optimization. Nat Commun. 2025 Aug 12;16(1):7430. doi: 10.1038/s41467-025-62645-6. Epub 2025 Aug 12. PMID: 40790034; PMCID: PMC12340016.

  • * Sharma K, Yakubu J, Pandey AV. Analysis of androgen modulation by natural products. Pharmacol Res. 2026 Sep;231:108377. doi: 10.1016/j.phrs.2026.108377. Epub 2026 Aug 10. PMID: 42575271.

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