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Published on: 10/14/2026
Tongkat ali (Eurycoma longifolia) may modestly raise testosterone in men with low baseline levels, mainly by lowering cortisol and freeing testosterone bound to SHBG, though results vary and are strongest in stressed or older adults. Reported side effects include insomnia, restlessness, irritability, headache, nausea, and in rare cases elevated liver enzymes or mercury contamination in poorly sourced products. It can also interact with blood pressure, diabetes, and hormone-sensitive conditions, and is not advised during pregnancy or breastfeeding. Dosage, extract quality, and how long you take it all change your risk profile, and there are several important factors to consider before starting. See below to understand more about safe dosing, who should avoid it, and what the research actually shows.
If you are dealing with low energy, low libido, mood changes, or symptoms you hoped a supplement would fix, it is worth finding out what is actually driving them before adding something new. Low testosterone symptoms overlap heavily with thyroid issues, sleep apnea, depression, anemia, and medication side effects, and a supplement will not help any of those. A free, instant, online symptom check takes just a few minutes, asks the kinds of questions a clinician would, and gives you a clearer picture of possible causes. That means you can walk into an appointment knowing what to ask for, which tests to request, and whether tongkat ali is even relevant to your situation.
Last reviewed for medical accuracy: 10/13/2025
Tongkat ali, also known as Eurycoma longifolia or “longjack,” is a traditional herbal supplement derived from the roots of a Southeast Asian plant. It’s commonly used to support male reproductive health, enhance athletic performance, and boost general well-being. One of its most talked-about benefits is its potential to raise testosterone levels. However, like any supplement, it can come with side effects and safety considerations.
Below, we’ll explore what tongkat ali does for testosterone, detail the known tongkat ali side effects, and offer practical advice on safe use. We’ll also suggest a free, online symptom check, using the doctor approved Ubie Symptom Checker. At the end, you’ll find guidance on when to speak to a healthcare professional.
Several human and animal studies suggest that tongkat ali may influence testosterone production and related pathways. While more large-scale trials are needed, the available research highlights a few key mechanisms:
Stimulating the Leydig Cells
Reducing Sex Hormone–Binding Globulin (SHBG)
Modulating the Hypothalamic–Pituitary–Gonadal (HPG) Axis
Stress Hormone Balance
Although tongkat ali is generally well tolerated, some individuals may experience unwanted effects. Understanding these tongkat ali side effects can help you make an informed choice and recognize when to seek medical advice.
Start Low and Go Slow
Typical Dosages
Timing
Quality Matters
Monitor Your Body
Though tongkat ali side effects are usually mild, certain signs warrant prompt attention:
If you experience any life-threatening or serious symptoms, stop using tongkat ali immediately and speak to a doctor without delay. For non-urgent questions, consider a free, online symptom check, using the doctor approved Ubie Symptom Checker to help clarify your next steps.
Tongkat ali offers a promising, plant-based way to support healthy testosterone levels, stress balance and male vitality. While most people tolerate it well, be aware of tongkat ali side effects—particularly mood changes, sleep disturbances and cardiovascular signs. Always start with a low dose, choose a reputable brand and monitor your body closely.
For personalized guidance, discuss tongkat ali use with your healthcare provider. And remember, if you ever face serious or worrying symptoms, seek medical help right away. Your health is paramount—staying informed and cautious ensures you enjoy the benefits safely.
(References)
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* Ahmad N, Teh BP, Halim SZ, Zolkifli NA, Ramli N, Muhammad H. Eurycoma longifolia-Infused Coffee-An Oral Toxicity Study. Nutrients. 2020 Oct 13;12(10). doi: 10.3390/nu12103125. Epub 2020 Oct 13. PMID: 33066137; PMCID: PMC7601993.
* Anand Ganapathy A, Hari Priya VM, Kumaran A. Medicinal plants as a potential source of Phosphodiesterase-5 inhibitors: A review. J Ethnopharmacol. 2021 Mar 1;267:113536. doi: 10.1016/j.jep.2020.113536. Epub 2020 Nov 1. PMID: 33137431.
* Leitão AE, Vieira MCS, Pelegrini A, da Silva EL, Guimarães ACA. A 6-month, double-blind, placebo-controlled, randomized trial to evaluate the effect of Eurycoma longifolia (Tongkat Ali) and concurrent training on erectile function and testosterone levels in androgen deficiency of aging males (ADAM). Maturitas. 2021 Mar;145:78-85. doi: 10.1016/j.maturitas.2020.12.002. Epub 2020 Dec 10. PMID: 33541567.
* Leisegang K, Finelli R, Sikka SC, Panner Selvam MK. Eurycoma longifolia (Jack) Improves Serum Total Testosterone in Men: A Systematic Review and Meta-Analysis of Clinical Trials. Medicina (Kaunas). 2022 Aug 4;58(8). doi: 10.3390/medicina58081047. Epub 2022 Aug 4. PMID: 36013514; PMCID: PMC9415500.
* Morgado A, Tsampoukas G, Sokolakis I, Schoentgen N, Urkmez A, Sarikaya S. Do "testosterone boosters" really increase serum total testosterone? A systematic review. Int J Impot Res. 2024 Jun;36(4):348-364. doi: 10.1038/s41443-023-00763-9. Epub 2023 Sep 11. PMID: 37697053.
* Tongkat Ali. 2012. PMID: 39527684.
* Zhang Z, Shi X, Wu T, He Z, Liang R, Ye W, Wu Z, Liao H, Zheng F, Yang Q, Zhao Z, Chen Y, Gao Z, Wang S, Wang M, Wang Z, Qi D, Yang M, Xu S, Wang Y, Zhao T, Egea J, Liu X, Pang J, Yi F, Zhan P. Discovery of multi-target anti-gout agents from Eurycoma longifolia Jack through phenotypic screening and structural optimization. Nat Commun. 2025 Aug 12;16(1):7430. doi: 10.1038/s41467-025-62645-6. Epub 2025 Aug 12. PMID: 40790034; PMCID: PMC12340016.
* Sharma K, Yakubu J, Pandey AV. Analysis of androgen modulation by natural products. Pharmacol Res. 2026 Sep;231:108377. doi: 10.1016/j.phrs.2026.108377. Epub 2026 Aug 10. PMID: 42575271.
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