Our Services
Medical Information
Helpful Resources
Published on: 10/30/2025
Does Tylenol interact with alcohol or other medications?
Tylenol, also known as acetaminophen, can interact with alcohol and other medications, potentially leading to liver damage or toxicity, especially when used in high doses or with certain drugs. See below to understand more.
What brings you in today?
Explanation
Tylenol, or acetaminophen, is a common pain reliever and fever reducer. However, it can have interactions with alcohol and other medications.
Alcohol Interaction:
- Drinking alcohol while taking acetaminophen can increase the risk of liver damage. This is because both alcohol and acetaminophen are processed by the liver, and using them together can put extra strain on it.
Medication Interactions:
- Certain medications can increase the risk of acetaminophen toxicity. For example, some drugs used to treat epilepsy might make acetaminophen more harmful to the liver.
- It is important to be cautious and consult a healthcare provider when using acetaminophen with other medications to avoid harmful effects.
In summary, while Tylenol is generally safe when used as directed, it is essential to be aware of its interactions with alcohol and other drugs, as these can lead to serious health risks.
(References)
- Toes MJ, Jones AL, & Prescott L. (2005). Drug interactions with paracetamol. American journal of therapeutics, 15662293.
- Jickling G, Heino A, & Ahmed SN. (2009). Acetaminophen toxicity with concomitant use .... Epileptic disorders : international epilepsy journal with videotape, 19995690.
- Kuffner EK, & Dart RC. (2001). Acetaminophen use in patients who drink alcohol. The American journal of managed care, 11776481.
Tell your friends about us.
We would love to help them too.
For First Time Users
What is Ubie’s Doctor’s Note?
We provide a database of explanations from real doctors on a range of medical topics. Get started by exploring our library of questions and topics you want to learn more about.
Learn more about symptoms
Was this page helpful?
Purpose and positioning of servicesUbie Doctor's Note is a service for informational purposes. The provision of information by physicians, medical professionals, etc. is not a medical treatment. If medical treatment is required, please consult your doctor or medical institution. We strive to provide reliable and accurate information, but we do not guarantee the completeness of the content. If you find any errors in the information, please contact us.