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Published on: 3/5/2025

Which Statins Cause Memory Loss?

Current research does not prove that one specific statin causes memory loss, but some studies hint that lipophilic statins like atorvastatin may be linked to memory issues in some people. More research is needed to fully understand the relationship.

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Explanation

Statins are drugs used to lower cholesterol and help protect the heart. Some people have reported memory loss while taking them, but the research is not clear enough to say that any one statin definitely causes memory problems. One study looked at how statin use might be related to memory decline in older people and found mixed results. Another recent study focused on atorvastatin and its possible link to memory loss, showing that some people might have issues with this particular drug. However, research reviewed by another group pointed out that statins may have different effects on the brain, with some studies suggesting they could protect against dementia while others suggest a risk of cognitive problems. It is important to know that not everyone experiences memory issues with statins, and many people benefit from lowering their cholesterol. Doctors usually weigh the risks and benefits when prescribing these medications. If you have concerns about memory loss while taking a statin, it is best to discuss them with your healthcare provider to review your treatment options.

(References)

  • Samaras K, Brodaty H, Sachdev PS. Does statin use cause memory decline in the elderly? Trends Cardiovasc Med. 2016 Aug;26(6):550-65. doi: 10.1016/j.tcm.2016.03.009. Epub 2016 Mar 28. PMID: 27177529.

  • Chen K, Chen Y, Huang H. Exploring the Relationship Between Atorvastatin and Memory Loss: A Comprehensive Analysis Integrating Real-World Pharmacovigilance and Mendelian Randomization. Drugs R D. 2024 Jun;24(2):317-329. doi: 10.1007/s40268-024-00474-6. Epub 2024 Jul 4. PMID: 38963511; PMCID: PMC11315864.

  • Schultz BG, Patten DK, Berlau DJ. The role of statins in both cognitive impairment and protection against dementia: a tale of two mechanisms. Transl Neurodegener. 2018 Feb 27;7:5. doi: 10.1186/s40035-018-0110-3. PMID: 29507718; PMCID: PMC5830056.

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