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Published on: 10/14/2026
Creatine can cause a quick increase on the scale, typically 1 to 4 pounds in the first week, but that weight is water pulled into your muscle cells, not body fat. With continued use alongside resistance training, any further gain usually reflects added lean muscle rather than fat, and the initial water retention often levels off or reverses after stopping. How much you gain depends on your dose, loading strategy, starting muscle mass, hydration, and diet, so there are several important factors to consider before judging the number on the scale, explained in full below.
If your weight change feels sudden, uneven, or comes with bloating, swelling, fatigue, or other symptoms that do not fit a normal creatine response, it is worth ruling out other causes rather than assuming it is just the supplement. A free, instant, online symptom check takes only a few minutes, helps you see which explanations best match what you are actually feeling, and points you toward the right next step, whether that is adjusting your routine or talking with a clinician.
Last reviewed for medical accuracy: 10/13/2025
Creatine is one of the most researched and widely used supplements in sports nutrition. If you’re asking “will creatine make you gain weight,” you’re not alone. Many people wonder whether taking creatine leads to unwanted fat gain or bloating. Here’s an evidence-based look at what really happens when you start supplementing with creatine.
Creatine is a naturally occurring compound found mainly in muscle cells. Your body uses it to:
When you supplement with creatine (most often as creatine monohydrate), you’re increasing the stores of phosphocreatine in your muscles. This provides extra fuel for activities like sprinting, weightlifting, or any short, powerful movement.
When considering “will creatine make you gain weight,” it helps to break weight gain into three categories:
Key studies:
Key points:
So, “will creatine make you gain weight?” Yes, but primarily through water retention and increased muscle mass—not by adding fat.
Creatine is one of the safest sports supplements on the market when used correctly.
Always follow dosing guidelines:
Although creatine is generally safe, if you experience any unusual symptoms—such as persistent digestive distress, muscle cramps, or changes in urination—you may wish to assess those symptoms further. You can try a free, online symptom check, using the doctor approved Ubie Symptom Checker.
Always speak to a doctor about anything that could be life-threatening or serious. Your healthcare provider can offer personalized advice based on your medical history and current health status.
Bottom Line:
Yes, creatine can make you gain weight, but the gain is mainly water and muscle, not fat. If you’re training hard and eating right, creatine is a safe, effective way to boost performance and support muscle growth without unwanted fat gain.
(References)
* Izquierdo M, Ibañez J, González-Badillo JJ, Gorostiaga EM. Effects of creatine supplementation on muscle power, endurance, and sprint performance. Med Sci Sports Exerc. 2002 Feb;34(2):332-43. doi: 10.1097/00005768-200202000-00023. PMID: 11828245.
* Kazak L, Chouchani ET, Jedrychowski MP, Erickson BK, Shinoda K, Cohen P, Vetrivelan R, Lu GZ, Laznik-Bogoslavski D, Hasenfuss SC, Kajimura S, Gygi SP, Spiegelman BM. A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat. Cell. 2015 Oct 22;163(3):643-55. doi: 10.1016/j.cell.2015.09.035. Epub 2015 Oct 22. PMID: 26496606; PMCID: PMC4656041.
* Kazak L, Cohen P. Creatine metabolism: energy homeostasis, immunity and cancer biology. Nat Rev Endocrinol. 2020 Aug;16(8):421-436. doi: 10.1038/s41574-020-0365-5. Epub 2020 Jun 3. PMID: 32493980.
* de Guingand DL, Palmer KR, Snow RJ, Davies-Tuck ML, Ellery SJ. Risk of Adverse Outcomes in Females Taking Oral Creatine Monohydrate: A Systematic Review and Meta-Analysis. Nutrients. 2020 Jun 15;12(6). doi: 10.3390/nu12061780. Epub 2020 Jun 15. PMID: 32549301; PMCID: PMC7353222.
* Almeida D, Colombini A, Machado M. Creatine supplementation improves performance, but is it safe? Double-blind placebo-controlled study. J Sports Med Phys Fitness. 2020 Jul;60(7):1034-1039. doi: 10.23736/S0022-4707.20.10437-7. PMID: 32597619.
* Maguire OA, Ackerman SE, Szwed SK, Maganti AV, Marchildon F, Huang X, Kramer DJ, Rosas-Villegas A, Gelfer RG, Turner LE, Ceballos V, Hejazi A, Samborska B, Rahbani JF, Dykstra CB, Annis MG, Luo JD, Carroll TS, Jiang CS, Dannenberg AJ, Siegel PM, Tersey SA, Mirmira RG, Kazak L, Cohen P. Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer. Cell Metab. 2021 Mar 2;33(3):499-512.e6. doi: 10.1016/j.cmet.2021.01.018. Epub 2021 Feb 16. PMID: 33596409; PMCID: PMC7954401.
* Sun Y, Rahbani JF, Jedrychowski MP, Riley CL, Vidoni S, Bogoslavski D, Hu B, Dumesic PA, Zeng X, Wang AB, Knudsen NH, Kim CR, Marasciullo A, Millán JL, Chouchani ET, Kazak L, Spiegelman BM. Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine. Nature. 2021 May;593(7860):580-585. doi: 10.1038/s41586-021-03533-z. Epub 2021 May 12. PMID: 33981039; PMCID: PMC8287965.
* Candow DG, Chilibeck PD, Forbes SC, Fairman CM, Gualano B, Roschel H. Creatine supplementation for older adults: Focus on sarcopenia, osteoporosis, frailty and Cachexia. Bone. 2022 Sep;162:116467. doi: 10.1016/j.bone.2022.116467. Epub 2022 Jun 7. PMID: 35688360.
* Hepler C, Weidemann BJ, Waldeck NJ, Marcheva B, Cedernaes J, Thorne AK, Kobayashi Y, Nozawa R, Newman MV, Gao P, Shao M, Ramsey KM, Gupta RK, Bass J. Time-restricted feeding mitigates obesity through adipocyte thermogenesis. Science. 2022 Oct 21;378(6617):276-284. doi: 10.1126/science.abl8007. Epub 2022 Oct 20. PMID: 36264811; PMCID: PMC10150371.
* Wideman C, Iemma A, Janolo O, Kalinina A, Murphy H. Effect of Creatine Monohydrate on Spatial Working Memory, Body Weight, and Food Intake in Male and Female Rats. Nutrients. 2025 Jul 4;17(13). doi: 10.3390/nu17132218. Epub 2025 Jul 4. PMID: 40647322; PMCID: PMC12251355.
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