Doctors Note Logo

Back

Published on: 5/6/2025

What Specific Factors Contribute to Chest Pain in Women?

The diverse causes of chest pain can present differently in women due to hormonal changes, smaller coronary arteries, and even how pain is perceived and expressed. These factors make chest pain in women sometimes appear different—often more subtle—than the classic symptoms seen in men.

answer background

Explanation

Women experience chest pain in ways that differ from men due to several specific factors. First, differences in heart anatomy and function play a role: women often have smaller coronary arteries and are more likely to have microvascular dysfunction, which means the tiny blood vessels in the heart do not work as well, leading to chest pain without obvious blockages. Hormonal changes, particularly fluctuations in estrogen levels, can also affect how the heart and blood vessels function. Furthermore, women may experience atypical symptoms such as burning, tightness, or pain that radiates to the back, neck, or jaw, rather than the classic crushing chest pain. Research also suggests that women might be more sensitive to pain or interpret it differently because of both biological and psychological factors. Because of these differences, it's important for healthcare providers to use gender-specific approaches when evaluating and treating chest pain in women.

(References)

  • Olic JJ, Baessler A, Fischer M. Brustschmerz und kardiovaskuläre Erkrankungen bei Frauen : Diagnostik und Therapie [Chest pain and cardiovascular diseases in women : Diagnostics and treatment]. Herz. 2023 Dec;48(6):487-498. German. doi: 10.1007/s00059-023-05215-0. Epub 2023 Nov 6. PMID: 37930367.

  • Granot M, Goldstein-Ferber S, Azzam ZS. Gender differences in the perception of chest pain. J Pain Symptom Manage. 2004 Feb;27(2):149-55. doi: 10.1016/j.jpainsymman.2003.05.009. PMID: 15157039.

  • Collins P, Vitale C, Spoletini I, Barbaro G. Gender differences in the clinical presentation of heart disease. Curr Pharm Des. 2011;17(11):1056-8. doi: 10.2174/138161211795656927. PMID: 21449890.

Tell your friends about us.

We would love to help them too.

smily Shiba-inu looking

For First Time Users

What is Ubie’s Doctor’s Note?

We provide a database of explanations from real doctors on a range of medical topics. Get started by exploring our library of questions and topics you want to learn more about.

Learn more about symptoms

Chest pain

Not sure about the cause of your current symptoms?

AI Symptom Check

Try our AI-based symptom checker

With an easy 3-min questionnaire, you can get a free AI-powered report on possible causes


Tips to try:

  • Provide specific, detailed info about all symptoms you have.
  • Give accurate information about yourself including current conditions.
  • Answer all follow-up questions

Purpose and positioning of servicesUbie Doctor’s Note is a service for informational purposes. The provision of information by physicians, medical professionals, etc. is not a medical treatment. If medical treatment is required, please consult your doctor or medical institution. We strive to provide reliable and accurate information, but we do not guarantee the completeness of the content. If you find any errors in the information, please contact us.