Overview
Fibromyalgia and multiple sclerosis can both cause widespread pain, fatigue, and cognitive issues, leading to potential confusion in diagnosis. While fibromyalgia primarily causes chronic pain and tenderness throughout the body, MS is a neurological condition that can also cause vision problems, muscle weakness, and coordination issues.
Disease Summaries
Fibromyalgia: This is a chronic condition characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and cognitive difficulties. Patients often experience tender points throughout their body and may have symptoms that wax and wane over time. While the exact cause remains unknown, research suggests it involves how the brain and spinal cord process pain signals, potentially triggered by genetics, infections, or physical/emotional trauma.
Multiple Sclerosis: This is a condition where the immune system attacks parts of the brain and spinal cord. The direct cause of MS remains unknown, but certain risk factors have been identified such as low vitamin D levels, tobacco smoking, exposure to UV radiation, childhood obesity, and infection with the virus that causes mononucleosis. The disease tends to affect young people more commonly as well as people living in higher latitudes. MS typically occurs in "attacks" which can include but are not limited to painful eye movements, blurry vision in one eye, numbness or weakness in hands or feet on one side, or double vision.
Comparing Symptoms
Overlapping Symptoms
- Fatigue
- Cognitive difficulties
- Sleep problems
- Muscle pain
- Depression
Fibromyalgia Specific Symptoms
- Tender points throughout body
- Morning stiffness
- Symptoms worsen with stress
- Irritable bowel symptoms
- Heightened sensitivity to pain
Multiple Sclerosis Specific Symptoms
- Vision problems
- Balance issues
- Muscle weakness
- Numbness or tingling sensation
- Heat sensitivity
Treatment Approaches
Fibromyalgia Treatment Approaches
Treatment involves a multi-faceted approach including medications for pain and sleep problems, physical therapy, and exercise programs. Stress-reduction techniques, cognitive behavioral therapy, and alternative therapies like acupuncture can help manage symptoms. Lifestyle modifications including regular sleep schedules and gentle exercise are crucial.
Multiple Sclerosis Treatment Approaches
Treatment of MS includes medications, physical/occupational therapy, lifestyle changes, and psychological support. Some medications prevent immune system attacks on the central nervous system, whereas others speed up recovery from attacks, or others reduce MS symptoms such as urinary problems or imbalanced walking. Physical therapy accelerates recovery from attacks and Lifestyle changes like quitting smoking can help reduce risk of further attacks.
Reviewed By:

Kenji Taylor, MD, MSc (Family Medicine, Primary Care)
Dr. Taylor is a Japanese-African American physician who grew up and was educated in the United States but spent a considerable amount of time in Japan as a college student, working professional and now father of three. After graduating from Brown, he worked in finance first before attending medical school at Penn. He then completed a fellowship with the Centers for Disease Control before going on to specialize in Family and Community Medicine at the University of California, San Francisco (UCSF) where he was also a chief resident. After a faculty position at Stanford, he moved with his family to Japan where he continues to see families on a military base outside of Tokyo, teach Japanese residents and serve remotely as a medical director for Roots Community Health Center. He also enjoys editing and writing podcast summaries for Hippo Education.

Shohei Harase, MD (Neurology)
Dr. Harase spent his junior and senior high school years in Finland and the U.S. After graduating from the University of Washington (Bachelor of Science, Molecular and Cellular Biology), he worked for Apple Japan Inc. before entering the University of the Ryukyus School of Medicine. He completed his residency at Okinawa Prefectural Chubu Hospital, where he received the Best Resident Award in 2016 and 2017. In 2021, he joined the Department of Cerebrovascular Medicine at the National Cerebral and Cardiovascular Center, specializing in hyperacute stroke.
Content updated on Mar 13, 2024
Following the Medical Content Editorial Policy
Was this page helpful?
Tell your friends about us.
We would love to help them too.
Still not sure if you need
to see a doctor?
Try a symptom check testHow Ubie Can Help You
With a free 3-min Fibromyalgia vs Multiple Sclerosis quiz, powered by Ubie's AI and doctors, find possible causes of your symptoms.
This questionnaire is customized to your situation and symptoms, including the following personal information:
Biological Sex - helps us provide relevant suggestions for male vs. female conditions.
Age - adjusts our guidance based on any age-related health factors.
History - considers past illnesses, surgeries, family history, and lifestyle choices.
Your symptoms

Our AI

Your report

Your personal report will tell you
✔ When to see a doctor
✔︎ What causes your symptoms
✔︎ Treatment information etc.
Ubie is supervised by 50+ medical experts worldwide
Our symptom checker AI is continuously refined with input from experienced physicians, empowering them to make more accurate diagnoses.






Ubie is recognized by healthcare and tech leaders

“World’s Best Digital
Health Companies”
Newsweek 2024

“Best With AI”
Google Play Best of 2023

“Best in Class”
Digital Health Awards 2023 (Quarterfinalist)

Which is the best Symptom Checker?
Ubie’s symptom checker demonstrated a Top-10 hit accuracy of 71.6%, surpassing the performance of several leading symptom checkers in the market, which averaged around 60% accuracy in similar assessments.
Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1References
Clauw DJ. Fibromyalgia: a clinical review. JAMA. 2014 Apr 16;311(15):1547-55. doi: 10.1001/jama.2014.3266. PMID: 24737367.
https://jamanetwork.com/journals/jama/article-abstract/1860480Bair MJ, Krebs EE. Fibromyalgia. Ann Intern Med. 2020 Mar 3;172(5):ITC33-ITC48. doi: 10.7326/AITC202003030. PMID: 32120395.
https://www.acpjournals.org/doi/10.7326/AITC202003030McGinley MP, Goldschmidt CH, Rae-Grant AD. Diagnosis and Treatment of Multiple Sclerosis: A Review. JAMA. 2021;325(8):765–779. doi:10.1001/jama.2020.26858
https://jamanetwork.com/journals/jama/article-abstract/2776694?casa_token=7gSU0m74lwoAAAAA:i0Mg1HziIGHT23muifKVtyc23MYu5YHqSm0tvuWhos5tIhfhHKyoavVwFAJsHfds_MCG4Kswo0eZ