Overview
Hives and eczema are both skin conditions that cause itching and irritation, but they differ in cause, appearance, and duration. Hives are sudden, raised welts usually triggered by an allergic reaction, and they tend to resolve quickly. Eczema is a chronic condition marked by dry, inflamed patches that may persist or recur over time due to immune system overactivity or environmental factors.
Disease Summaries
Hives: Hives are itchy, allergic rashes with red bumps, also known as urticaria. The causes are broad, ranging from foods and medications to viral infections and bee stings. In most cases, the rash disappears within 24 hours, however medical attention is needed if there is facial swelling or breathlessness.
Eczema: Eczema or atopic dermatitis is a chronic inflammatory skin condition where the immune system overreacts to triggers, leading to itchy, red, and dry skin. The direct cause remains unclear, but it is associated with genetic factors, a defective skin barrier, and environmental irritants such as allergens, soaps, and stress. It commonly begins in childhood and tends to affect people with a family history of allergies or asthma. Flare-ups may involve patches of scaly, cracked skin, especially on the hands, face, elbows, or behind the knees, often accompanied by intense itching.
Comparing Symptoms
Overlapping Symptoms
- Itchy skin
- Redness or inflammation
- Skin discomfort or irritation
- Possible swelling
Hives Specific Symptoms
- Raised, red or skin-colored welts
- Welts may change shape, move, or disappear within hours
- Sudden onset, often due to allergens (food, medication, insect bites)
- May be accompanied by swelling (angioedema)
- Skin returns to normal after the flare ends
Eczema Specific Symptoms
- Dry, scaly patches (often on elbows, knees, face, or hands)
- Chronic or recurring rash
- Thickened or cracked skin from repeated scratching
- Can ooze or crust in severe cases
- Triggered by irritants, stress, weather changes, or allergens
Treatment Approaches
Hives Treatment Approaches
Treatment usually involves antihistamines to stop the allergic reaction. Severe cases (e.g. swollen lips and eyes or breathlessness) may require emergency medical care. It is important to identify and avoid the cause of the allergy in the future.
Eczema Treatment Approaches
Treatment focuses on reducing inflammation, relieving itching, and repairing the skin barrier. This includes the use of topical corticosteroids, calcineurin inhibitors, and moisturizers applied regularly. Antihistamines may help reduce itching, while antibiotics are used if a secondary bacterial infection develops. Identifying and avoiding triggers is key to managing flare-ups. In severe or resistant cases, phototherapy or systemic immunosuppressants may be considered.
Reviewed By:

Kenji Taylor, MD, MSc (Family Medicine, Primary Care)
Dr. Taylor is a Japanese-African American physician who grew up and was educated in the United States but spent a considerable amount of time in Japan as a college student, working professional and now father of three. After graduating from Brown, he worked in finance first before attending medical school at Penn. He then completed a fellowship with the Centers for Disease Control before going on to specialize in Family and Community Medicine at the University of California, San Francisco (UCSF) where he was also a chief resident. After a faculty position at Stanford, he moved with his family to Japan where he continues to see families on a military base outside of Tokyo, teach Japanese residents and serve remotely as a medical director for Roots Community Health Center. He also enjoys editing and writing podcast summaries for Hippo Education.

Yukiko Ueda, MD (Dermatology)
Dr. Ueda graduated from the Niigata University School of Medicine and trained at the University of Tokyo Medical School. She is currently a clinical assistant professor at the Department of Dermatology, Jichi Medical University, and holds several posts in the dermatology departments at Kyoto Prefectural University of Medicine, Komagome Hospital, University of Tokyo, and the Medical Center of Japan Red Cross Society.
Content updated on Apr 29, 2025
Following the Medical Content Editorial Policy
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Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1References
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https://link.springer.com/chapter/10.1007/978-3-319-64804-0_3Avena-Woods C. Overview of atopic dermatitis. Am J Manag Care. 2017 Jun;23(8 Suppl):S115-S123. PMID: 28978208.
https://www.ajmc.com/view/overview-of-atopic-dermatitis-articleSaini SS, Kaplan AP. Chronic Spontaneous Urticaria: The Devil's Itch. J Allergy Clin Immunol Pract. 2018 Jul-Aug;6(4):1097-1106. doi: 10.1016/j.jaip.2018.04.013. PMID: 30033911; PMCID: PMC6061968.
https://www.jaci-inpractice.org/article/S2213-2198(18)30290-3/fulltext