Localized Cutaneous Amyloidosis Quiz
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Skin has moles or spots of different colors
Redness of the skin
Multiple areas of skin redness or red spots
Black, blue, or brown spots on the skin or elsewhere
Red spots on skin
Redness over different parts of the body
Discolored macules or moles on skin/mucus membranes
Not seeing your symptoms? No worries!
What is Localized Cutaneous Amyloidosis?
Localized cutaneous amyloidosis is a rare condition where amyloid protein accumulates between the superficial and deeper layers of the skin. The cause is unknown but may be triggered by repeated scratching and rubbing of the skin due to other skin conditions.
Typical Symptoms of Localized Cutaneous Amyloidosis
- Black/blue/brown spots or moles, on the skin and lining of the mouth
- Dark spots on skin
- Hard or stiff skin
- Multiple areas of skin redness or red spots
- Itchy skin
- Scratched skin until damaged
- Skin problems
- Redness, bumps, or irritation on the skin
Diagnostic Questions for Localized Cutaneous Amyloidosis
Your doctor may ask these questions to check for this disease:
- Are there black, blue, or brown spots on your skin? (Including moles)
- Do you have darkened skin?
- Have you noticed any hard or stiff areas on your skin?
- Do you have multiple red areas or spots on your skin?
- Do you have itchy skin?
Treatment of Localized Cutaneous Amyloidosis
Localized cutaneous amyloidosis causes focal hyperpigmentation and thickening of the skin. Treatment is aimed at controlling the underlying itch, with topical and/or oral therapies.
Reviewed By:
Sarita Nori, MD (Dermatology)
Dr. Sarita Nori was drawn to dermatology because of the intersection of science and medicine that is at the heart of dermatology. She feels this is what really allows her to help her patients. “There is a lot of problem-solving in dermatology and I like that,” she explains. “It’s also a profession where you can help people quickly and really make a difference in their lives.” | Some of the typical skin problems that Dr. Nori treats include skin cancers, psoriasis, acne, eczema, rashes, and contact dermatitis. Dr Nori believes in using all possible avenues of treatment, such as biologics, especially in patients with chronic diseases such as eczema and psoriasis. “These medications can work superbly, and they are really life-changing for many patients.” | Dr. Nori feels it’s important for patients to have a good understanding of the disease or condition that is affecting them. “I like to educate my patients on their problem and have them really understand it so they can take the best course of action. Patients always do better when they understand their skin condition, and how to treat it.”
Yukiko Ueda, MD (Dermatology)
Dr. Ueda graduated from the Niigata University School of Medicine and trained at the University of Tokyo Medical School. She is currently a clinical assistant professor at the Department of Dermatology, Jichi Medical University, and holds several posts in the dermatology departments at Kyoto Prefectural University of Medicine, Komagome Hospital, University of Tokyo, and the Medical Center of Japan Red Cross Society.
Content updated on Mar 31, 2024
Following the Medical Content Editorial Policy
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- Dark skin
- Scars or marks from the rash/wound
- Moles or spots of different colors on skin or lining of the mouth
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- There is darkened skin on the toe
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- Tightening of the skin of the fingers
- The skin is itchy and has scratches
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- There is darkened skin on the chin
- There is darkened skin on the under the armpit
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See full list
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Diseases Related to Localized Cutaneous Amyloidosis
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Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1References
Weidner T, Illing T, Elsner P. Primary Localized Cutaneous Amyloidosis: A Systematic Treatment Review. Am J Clin Dermatol. 2017 Oct;18(5):629-642. doi: 10.1007/s40257-017-0278-9. PMID: 28342017.
https://link.springer.com/article/10.1007/s40257-017-0278-9Hamie L, Haddad I, Nasser N, Kurban M, Abbas O. Primary Localized Cutaneous Amyloidosis of Keratinocyte Origin: An Update with Emphasis on Atypical Clinical Variants. Am J Clin Dermatol. 2021 Sep;22(5):667-680. doi: 10.1007/s40257-021-00620-9. Epub 2021 Jul 21. PMID: 34286474.
https://link.springer.com/article/10.1007/s40257-021-00620-9Madarkar MS, Koti VR. FotoFinder Dermoscopy Analysis and Histopathological Correlation in Primary Localized Cutaneous Amyloidosis. Dermatol Pract Concept. 2021 May 20;11(3):e2021057. doi: 10.5826/dpc.1103a57. PMID: 34123561; PMCID: PMC8172053.
https://www.dpcj.org/index.php/dpc/article/view/dermatol-pract-concept-articleid-dp1103a57