Localized Cutaneous Amyloidosis Quiz

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Learn more about Localized cutaneous amyloidosis

Content updated on Sep 20, 2022

What is localized cutaneous amyloidosis?

Localised cutaneous amyloidosis is a condition in which there is accumulation of a protein called amyloid in between the superficial and deeper layer of the skin. The cause is unknown, but could be triggered due to repeated scratching and rubbing of the skin due to other skin conditions.

Symptoms of localized cutaneous amyloidosis

  • Black/blue/brown spots or moles, on the skin and lining of the mouth

  • Skin hardening

  • Multiple areas of skin redness or red spots

Questions your doctor may ask to check for localized cutaneous amyloidosis

Your doctor may ask these questions to diagnose localized cutaneous amyloidosis

  • Are there black, blue, or brown spots on the skin or elsewhere? (Including moles)

  • Do you have hardening of the skin?

  • Do you have multiple areas of skin which are reddened or have red spots?

Treatment for localized cutaneous amyloidosis

Localised cutaneous amyloidosis causes cosmetic defects hence medications are given to treat the patches, which can include oral pills, injections and creams/ ointments.

View the symptoms of Localized cutaneous amyloidosis


  • Weidner T, Illing T, Elsner P. Primary Localized Cutaneous Amyloidosis: A Systematic Treatment Review. Am J Clin Dermatol. 2017 Oct;18(5):629-642. doi: 10.1007/s40257-017-0278-9. PMID: 28342017.


  • Hamie L, Haddad I, Nasser N, Kurban M, Abbas O. Primary Localized Cutaneous Amyloidosis of Keratinocyte Origin: An Update with Emphasis on Atypical Clinical Variants. Am J Clin Dermatol. 2021 Sep;22(5):667-680. doi: 10.1007/s40257-021-00620-9. Epub 2021 Jul 21. PMID: 34286474.


  • Madarkar MS, Koti VR. FotoFinder Dermoscopy Analysis and Histopathological Correlation in Primary Localized Cutaneous Amyloidosis. Dermatol Pract Concept. 2021 May 20;11(3):e2021057. doi: 10.5826/dpc.1103a57. PMID: 34123561; PMCID: PMC8172053.


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Yukiko Ueda

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From our team of 50+ doctors

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