Localized Cutaneous Amyloidosis Quiz

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Yukiko Ueda, MD

Yukiko Ueda, MD (Dermatology)

Dr. Ueda graduated from the Niigata University School of Medicine and trained at the University of Tokyo Medical School. She is currently a clinical assistant professor at the Department of Dermatology, Jichi Medical University, and holds several posts in the dermatology departments at Kyoto Prefectural University of Medicine, Komagome Hospital, University of Tokyo, and the Medical Center of Japan Red Cross Society.

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People with similar symptoms also use Ubie's symptom checker to find possible causes

  • Skin tightness of the fingers

  • Scars or marks from the rash/wound

  • Moles or spots of different colors on skin or lining of the mouth

  • Hard fingertips

  • Developed scars or marks where the rashes/wound was previously

  • Hardening of the skin of the fingers

  • After the rash healed, there were scars

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Learn more about Localized cutaneous amyloidosis

Content updated on Sep 20, 2022

What is localized cutaneous amyloidosis?

Localized cutaneous amyloidosis is a condition where amyloid protein accumulates between the superficial and deeper layers of the skin. The cause is unknown but may be triggered by repeated scratching and rubbing of the skin due to other skin conditions.

Symptoms of localized cutaneous amyloidosis

  • Black/blue/brown spots or moles, on the skin and lining of the mouth

  • Skin hardening

  • Multiple areas of skin redness or red spots

Questions your doctor may ask to check for localized cutaneous amyloidosis

Your doctor may ask these questions to diagnose localized cutaneous amyloidosis

  • Are there black, blue, or brown spots on the skin or elsewhere? (Including moles)

  • Do you have hardening of the skin?

  • Do you have multiple areas of skin which are reddened or have red spots?

Treatment for localized cutaneous amyloidosis

Localized cutaneous amyloidosis causes cosmetic defects, so medications are given to treat the patches. These can include oral pills, injections, and creams/ointments.

View the symptoms of Localized cutaneous amyloidosis

References

  • Weidner T, Illing T, Elsner P. Primary Localized Cutaneous Amyloidosis: A Systematic Treatment Review. Am J Clin Dermatol. 2017 Oct;18(5):629-642. doi: 10.1007/s40257-017-0278-9. PMID: 28342017.

    https://link.springer.com/article/10.1007/s40257-017-0278-9

  • Hamie L, Haddad I, Nasser N, Kurban M, Abbas O. Primary Localized Cutaneous Amyloidosis of Keratinocyte Origin: An Update with Emphasis on Atypical Clinical Variants. Am J Clin Dermatol. 2021 Sep;22(5):667-680. doi: 10.1007/s40257-021-00620-9. Epub 2021 Jul 21. PMID: 34286474.

    https://link.springer.com/article/10.1007/s40257-021-00620-9

  • Madarkar MS, Koti VR. FotoFinder Dermoscopy Analysis and Histopathological Correlation in Primary Localized Cutaneous Amyloidosis. Dermatol Pract Concept. 2021 May 20;11(3):e2021057. doi: 10.5826/dpc.1103a57. PMID: 34123561; PMCID: PMC8172053.

    https://www.dpcj.org/index.php/dpc/article/view/dermatol-pract-concept-articleid-dp1103a57

User testimonials

Reviewed By:

Yukiko Ueda, MD

Yukiko Ueda, MD (Dermatology)

Dr. Ueda graduated from the Niigata University School of Medicine and trained at the University of Tokyo Medical School. She is currently a clinical assistant professor at the Department of Dermatology, Jichi Medical University, and holds several posts in the dermatology departments at Kyoto Prefectural University of Medicine, Komagome Hospital, University of Tokyo, and the Medical Center of Japan Red Cross Society.

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