What are the symptoms of Mastocytosis?

Symptoms of Mastocytosis are: (1) Skin over the entire body is red. (2) Black/blue/brown spots or moles, on the skin and lining of the mouth. (3) Welts appear when skin is scratched or rubbed. (4) Redness in sun-exposed areas of skin. (5) Skin redness or red bumpy rashes

Mastocytosis Quiz

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Reviewed By:

Caroline M. Doan, DO (Internal Medicine)

Dr. Doan received a Bachelor of Science degree with honors from UCLA. Prior to obtaining her medical degree, she was involved in oncology clinical research at City of Hope, a National Cancer Institute-designated comprehensive cancer center in southern California. She attended medical school at Touro University California, and completed her residency in Internal Medicine at Oregon Health & Science University. She is certified by the American Board of Internal Medicine and holds an active medical license in several states. She currently works as a physician for Signify Health providing home-based health care.

Yuta Sasaoka, MD (Pediatrics)

Dr. Sasaoka graduated from the Sapporo Medical University School of Medicine. After working in the Department of Pediatrics at Hakodate Municipal Hospital, the Emergency Center at Hakodate Municipal Hospital, and the Department of Emergency Medicine at Tokyo Metropolitan Children's General Medical Center, he joined the Sapporo Medical University Advanced Emergency Medical Center in April 2020. Dr. Sasaoka is well versed in pediatric emergency medicine, covering a wide range of pediatrics and emergency medicine. He is also a certified AHA-PALS instructor and focuses on pediatric secondary life support education at the Hokkaido Training Site.

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Content updated on Mar 31, 2024

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Redness of the skin

Skin has moles or spots of different colors

Rashes in areas of friction

Red when exposed to the sun

Red spots on skin

Black, blue, or brown spots on the skin or elsewhere

Rashes over sun-exposed areas

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Biological Sex - helps us provide relevant suggestions for male vs. female conditions.
Age - adjusts our guidance based on any age-related health factors.
History - considers past illnesses, surgeries, family history, and lifestyle choices.

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Moles or spots of different colors on skin or lining of the mouth
Red rash
Pink rash
Itchy skin not covered by clothes is itchy
There is a dry bumpy rash on the skin
Rash on the head
Might have allergy symptoms

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What is Mastocytosis?

Mastocytosis happens when there are too many mast cells, which are part of the immune system, in the body. It can affect the skin or other body parts. It's usually caused by a non-inherited genetic mutation and affects both genders equally. Mastocytosis attacks can be triggered by skin friction, physical activity, insect bites, stress, alcohol, certain foods, and medications.

Typical Symptoms of Mastocytosis

Skin over the entire body is red
Black/blue/brown spots or moles, on the skin and lining of the mouth
Welts appear when skin is scratched or rubbed
Redness in sun-exposed areas of skin
Skin redness or red bumpy rashes

Doctor's Diagnostic Questionson Mastocytosis

Your doctor may ask these questions to check for this disease:

Is your whole body red?
Are there black, blue, or brown spots on your skin? (Including moles)
Does your skin get red from friction or irritation?
Do you have redness on sun-exposed skin?
Do you have red skin or red spots?

Treatmentof Mastocytosis

People with mastocytosis should avoid triggers. Treatment options include medications to lessen symptoms or ultraviolet light therapy. Since there's a higher risk of a severe allergic reaction (anaphylactic shock), they should carry an EpiPen (injectable epinephrine).

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Mastocytosis

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Diseases related to Mastocytosis

References

Hussain SH. Pediatric mastocytosis. Curr Opin Pediatr. 2020 Aug;32(4):531-538. doi: 10.1097/MOP.0000000000000922. PMID: 32692050.
https://journals.lww.com/co-pediatrics/Abstract/2020/08000/Pediatric_mastocytosis.14.aspx
Bergström A, Rollman O, Emtestam L, Mattson M, Hägglund H, Nilsson G, Karlsson M. Mastocytos i huden – uppdatering av kunskapsläget och riktlinjer för handläggning [Cutaneous mastocytosis - update and clinical guidelines]. Lakartidningen. 2018 Oct 22;115:FASY. Swedish. PMID: 30351439.
https://lakartidningen.se/klinik-och-vetenskap-1/artiklar-1/klinisk-oversikt/2018/10/mastocytos-i-huden-uppdatering-av-kunskapslaget-och-riktlinjer-for-handlaggning/
Carter MC, Metcalfe DD, Komarow HD. Mastocytosis. Immunol Allergy Clin North Am. 2014 Feb;34(1):181-96. doi: 10.1016/j.iac.2013.09.001. Epub 2013 Oct 7. PMID: 24262698; PMCID: PMC3863935.
https://www.sciencedirect.com/science/article/abs/pii/S0889856113000647?via%3Dihub
Krishnaprasadh D, Levasseur K. Mastocytosis. Pediatr Rev. 2021 Aug;42(8):468-470. doi: 10.1542/PIR.2020-0108. PMID: 34341090.
https://publications.aap.org/pediatricsinreview/article-abstract/42/8/468/180031/Mastocytosis?redirectedFrom=fulltext