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Learn more about Mastocytosis
Content updated on Jun 1, 2022
What is mastocytosis?
Mastocytosis occurs when there are excessive numbers of mast cells (part of the immune system) in the body. This can affect the skin or other parts of the body. It's generally due to a non-inherited genetic mutation, and affects both sexes equally. Triggers of mastocytosis attacks include friction on the skin, physical activity, insect bites, stress, alcohol, certain food and medications.
Symptoms related to mastocytosis
Welts appear when skin is scratched or rubbed
Black/blue/brown spots or moles, on the skin and lining of the mouth
Redness in sun-exposed areas of skin
Questions your doctor may ask to check for mastocytosis
Your doctor may ask these questions to diagnose mastocytosis
Is your skin red in places where it is exposed to friction or irritation?
Are there black, blue, or brown spots on the skin or elsewhere? (Including moles)
Do you have redness on the sun-exposed areas of your skin?
Treatment for mastocytosis
People with mastocytosis should reduce exposure to triggers. Treatment includes medications to reduce symptoms or ultraviolet light therapy. Since there's an increased risk of a severe allergic reaction (anaphylactic shock), they should carry an EpiPen (injectable epinephrine).
View the symptoms of Mastocytosis
Diseases related to Mastocytosis
References
Hussain SH. Pediatric mastocytosis. Curr Opin Pediatr. 2020 Aug;32(4):531-538. doi: 10.1097/MOP.0000000000000922. PMID: 32692050.
https://journals.lww.com/co-pediatrics/Abstract/2020/08000/Pediatric_mastocytosis.14.aspx
Bergström A, Rollman O, Emtestam L, Mattson M, Hägglund H, Nilsson G, Karlsson M. Mastocytos i huden – uppdatering av kunskapsläget och riktlinjer för handläggning [Cutaneous mastocytosis - update and clinical guidelines]. Lakartidningen. 2018 Oct 22;115:FASY. Swedish. PMID: 30351439.
https://lakartidningen.se/klinik-och-vetenskap-1/artiklar-1/klinisk-oversikt/2018/10/mastocytos-i-huden-uppdatering-av-kunskapslaget-och-riktlinjer-for-handlaggning/
Carter MC, Metcalfe DD, Komarow HD. Mastocytosis. Immunol Allergy Clin North Am. 2014 Feb;34(1):181-96. doi: 10.1016/j.iac.2013.09.001. Epub 2013 Oct 7. PMID: 24262698; PMCID: PMC3863935.
https://www.sciencedirect.com/science/article/abs/pii/S0889856113000647?via%3Dihub
Krishnaprasadh D, Levasseur K. Mastocytosis. Pediatr Rev. 2021 Aug;42(8):468-470. doi: 10.1542/PIR.2020-0108. PMID: 34341090.
https://publications.aap.org/pediatricsinreview/article-abstract/42/8/468/180031/Mastocytosis?redirectedFrom=fulltext
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Seiji Kanazawa, MD, PHD
Obstetrics and gynecology (OBGYN)
National Center for Child Health and Development, Japan