What are the symptoms of mastocytosis?

Symptoms of MASTOCYTOSIS are: (1) Black/blue/brown spots or moles, on the skin and lining of the mouth. (2) Welts appear when skin is scratched or rubbed. (3) Redness in sun-exposed areas of skin. (4) Skin over the entire body is red

Mastocytosis Quiz

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Reviewed By:

Caroline M. Doan, DO (Internal medicine)

Dr. Doan received a Bachelor of Science degree with honors from UCLA. Prior to obtaining her medical degree, she was involved in oncology clinical research at City of Hope, a National Cancer Institute-designated comprehensive cancer center in southern California. She attended medical school at Touro University California, and completed her residency in Internal Medicine at Oregon Health & Science University. She is certified by the American Board of Internal Medicine and holds an active medical license in several states. She currently works as a physician for Signify Health providing home-based health care.

Yuta Sasaoka, MD (Pediatrics)

Dr. Sasaoka graduated from the Sapporo Medical University School of Medicine. After working in the Department of Pediatrics at Hakodate Municipal Hospital, the Emergency Center at Hakodate Municipal Hospital, and the Department of Emergency Medicine at Tokyo Metropolitan Children's General Medical Center, he joined the Sapporo Medical University Advanced Emergency Medical Center in April 2020. Dr. Sasaoka is well versed in pediatric emergency medicine, covering a wide range of pediatrics and emergency medicine. He is also a certified AHA-PALS instructor and focuses on pediatric secondary life support education at the Hokkaido Training Site.

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Redness of the skin

Skin has moles or spots of different colors

Rashes in areas of friction

Red when exposed to the sun

Red spots on skin

Black, blue, or brown spots on the skin or elsewhere

Rashes over sun-exposed areas

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People with these symptoms also use Ubie's symptom checker to find possible causes

Discolored macules or moles on skin/mucus membranes
Black/blue/brown spots or moles, on the skin and lining of the mouth
Moles or spots of different colors on skin or lining of the mouth

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Learn more about Mastocytosis

Content updated on Sep 20, 2022

What is mastocytosis?

Mastocytosis happens when there are too many mast cells, which are part of the immune system, in the body. It can affect the skin or other body parts. It's usually caused by a non-inherited genetic mutation and affects both genders equally. Mastocytosis attacks can be triggered by skin friction, physical activity, insect bites, stress, alcohol, certain foods, and medications.

Symptoms of mastocytosis

Black/blue/brown spots or moles, on the skin and lining of the mouth
Welts appear when skin is scratched or rubbed
Redness in sun-exposed areas of skin
Skin over the entire body is red

Questions your doctor may ask to check for mastocytosis

Your doctor may ask these questions to diagnose mastocytosis

Are there black, blue, or brown spots on the skin or elsewhere? (Including moles)
Is your skin red in places where it is exposed to friction or irritation?
Do you have redness on the sun-exposed areas of your skin?
Do you have skin redness over the whole body?

Treatment for mastocytosis

People with mastocytosis should avoid triggers. Treatment options include medications to lessen symptoms or ultraviolet light therapy. Since there's a higher risk of a severe allergic reaction (anaphylactic shock), they should carry an EpiPen (injectable epinephrine).

View the symptoms of Mastocytosis

Moles on the skin and lining of the mouth

Diseases related to Mastocytosis

References

Hussain SH. Pediatric mastocytosis. Curr Opin Pediatr. 2020 Aug;32(4):531-538. doi: 10.1097/MOP.0000000000000922. PMID: 32692050.
https://journals.lww.com/co-pediatrics/Abstract/2020/08000/Pediatric_mastocytosis.14.aspx
Bergström A, Rollman O, Emtestam L, Mattson M, Hägglund H, Nilsson G, Karlsson M. Mastocytos i huden – uppdatering av kunskapsläget och riktlinjer för handläggning [Cutaneous mastocytosis - update and clinical guidelines]. Lakartidningen. 2018 Oct 22;115:FASY. Swedish. PMID: 30351439.
https://lakartidningen.se/klinik-och-vetenskap-1/artiklar-1/klinisk-oversikt/2018/10/mastocytos-i-huden-uppdatering-av-kunskapslaget-och-riktlinjer-for-handlaggning/
Carter MC, Metcalfe DD, Komarow HD. Mastocytosis. Immunol Allergy Clin North Am. 2014 Feb;34(1):181-96. doi: 10.1016/j.iac.2013.09.001. Epub 2013 Oct 7. PMID: 24262698; PMCID: PMC3863935.
https://www.sciencedirect.com/science/article/abs/pii/S0889856113000647?via%3Dihub
Krishnaprasadh D, Levasseur K. Mastocytosis. Pediatr Rev. 2021 Aug;42(8):468-470. doi: 10.1542/PIR.2020-0108. PMID: 34341090.
https://publications.aap.org/pediatricsinreview/article-abstract/42/8/468/180031/Mastocytosis?redirectedFrom=fulltext