What are the symptoms of mastocytosis?

Symptoms of MASTOCYTOSIS are: (1) Black/blue/brown spots or moles, on the skin and lining of the mouth. (2) Welts appear when skin is scratched or rubbed. (3) Redness in sun-exposed areas of skin

Mastocytosis Quiz

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Caroline M. Doan, DO (Internal medicine)

Yuta Sasaoka, MD (Pediatrics)

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Redness of the skin

Skin has moles or spots of different colors

Rashes in areas of friction

Red when exposed to the sun

Red spots on skin

Black, blue, or brown spots on the skin or elsewhere

Rashes over sun-exposed areas

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Learn more about Mastocytosis

Content updated on Sep 20, 2022

What is mastocytosis?

Mastocytosis occurs when there are excessive numbers of mast cells (part of the immune system) in the body. This can affect the skin or other parts of the body. It's generally due to a non-inherited genetic mutation, and affects both sexes equally. Triggers of mastocytosis attacks include friction on the skin, physical activity, insect bites, stress, alcohol, certain food and medications.

Symptoms of mastocytosis

Black/blue/brown spots or moles, on the skin and lining of the mouth
Welts appear when skin is scratched or rubbed
Redness in sun-exposed areas of skin

Questions your doctor may ask to check for mastocytosis

Your doctor may ask these questions to diagnose mastocytosis

Are there black, blue, or brown spots on the skin or elsewhere? (Including moles)
Is your skin red in places where it is exposed to friction or irritation?
Do you have redness on the sun-exposed areas of your skin?

Treatment for mastocytosis

People with mastocytosis should reduce exposure to triggers. Treatment includes medications to reduce symptoms or ultraviolet light therapy. Since there's an increased risk of a severe allergic reaction (anaphylactic shock), they should carry an EpiPen (injectable epinephrine).

View the symptoms of Mastocytosis

Moles on the skin and lining of the mouth

Diseases related to Mastocytosis

References

Hussain SH. Pediatric mastocytosis. Curr Opin Pediatr. 2020 Aug;32(4):531-538. doi: 10.1097/MOP.0000000000000922. PMID: 32692050.
https://journals.lww.com/co-pediatrics/Abstract/2020/08000/Pediatric_mastocytosis.14.aspx
Bergström A, Rollman O, Emtestam L, Mattson M, Hägglund H, Nilsson G, Karlsson M. Mastocytos i huden – uppdatering av kunskapsläget och riktlinjer för handläggning [Cutaneous mastocytosis - update and clinical guidelines]. Lakartidningen. 2018 Oct 22;115:FASY. Swedish. PMID: 30351439.
https://lakartidningen.se/klinik-och-vetenskap-1/artiklar-1/klinisk-oversikt/2018/10/mastocytos-i-huden-uppdatering-av-kunskapslaget-och-riktlinjer-for-handlaggning/
Carter MC, Metcalfe DD, Komarow HD. Mastocytosis. Immunol Allergy Clin North Am. 2014 Feb;34(1):181-96. doi: 10.1016/j.iac.2013.09.001. Epub 2013 Oct 7. PMID: 24262698; PMCID: PMC3863935.
https://www.sciencedirect.com/science/article/abs/pii/S0889856113000647?via%3Dihub
Krishnaprasadh D, Levasseur K. Mastocytosis. Pediatr Rev. 2021 Aug;42(8):468-470. doi: 10.1542/PIR.2020-0108. PMID: 34341090.
https://publications.aap.org/pediatricsinreview/article-abstract/42/8/468/180031/Mastocytosis?redirectedFrom=fulltext

Reviewed By:

Caroline M. Doan, DO (Internal medicine)

Yuta Sasaoka, MD (Pediatrics)

From our team of 50+ doctors

Just 3 minutes.
Developed by doctors.