Necrotizing Lymphadenitis (Kikuchi Disease) Quiz
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Have a fever
Lymph swollen
Redness of the skin
Periodic fever (>100.4°F / 38°C)
Fatigued
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What is Necrotizing Lymphadenitis (Kikuchi Disease)?
This rare disease usually affects young people and is characterized by swollen neck lymph nodes and fever. The exact cause remains unknown, but it may be due to infection or the body's immune system reacting.
Typical Symptoms of Necrotizing Lymphadenitis (Kikuchi Disease)
- Swollen lymph nodes or lumps in the neck, armpits, groin, or behind the ears
- Fever
- Swelling around the front and sides of the neck
- Recurrent fever episodes
- Neck pain or stiffness
- Lymph nodes swollen but not painful when touched
- Neck lump
- Fatigue or low energy
Diagnostic Questions for Necrotizing Lymphadenitis (Kikuchi Disease)
Your doctor may ask these questions to check for this disease:
- Do you have any swollen lymph nodes or lumps in your neck, armpits, groin, or behind your ears?
- Do you have a fever?
- Is your neck swollen?
- Do you have recurrent fever episodes?
- Do you have neck pain or stiffness?
Treatment of Necrotizing Lymphadenitis (Kikuchi Disease)
The condition typically resolves on its own, and treatment is primarily supportive. Medications can be used to treat fever and lymph node tenderness symptoms.
Reviewed By:
Caroline M. Doan, DO (Internal Medicine)
Dr. Doan received a Bachelor of Science degree with honors from UCLA. Prior to obtaining her medical degree, she was involved in oncology clinical research at City of Hope, a National Cancer Institute-designated comprehensive cancer center in southern California. She attended medical school at Touro University California, and completed her residency in Internal Medicine at Oregon Health & Science University. She is certified by the American Board of Internal Medicine and holds an active medical license in several states. She currently works as a physician for Signify Health providing home-based health care.
Yoshinori Abe, MD (Internal Medicine)
Dr. Abe graduated from The University of Tokyo School of Medicine in 2015. He completed his residency at the Tokyo Metropolitan Health and Longevity Medical Center. He co-founded Ubie, Inc. in May 2017, where he currently serves as CEO & product owner at Ubie. Since December 2019, he has been a member of the Special Committee for Activation of Research in Emergency AI of the Japanese Association for Acute Medicine. | | Dr. Abe has been elected in the 2020 Forbes 30 Under 30 Asia Healthcare & Science category.
Content updated on Feb 13, 2025
Following the Medical Content Editorial Policy
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Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1References
Perry, A. M., & Choi, S. M. (2018). Kikuchi-Fujimoto disease: a review. Archives of Pathology & Laboratory.
https://meridian.allenpress.com/aplm/article-abstract/142/11/1341/103043Dumas, G., Prendki, V., Haroche, J., Amoura, Z., Cacoub, P., ... (2014). Kikuchi-Fujimoto disease: retrospective study of 91 cases and review of the literature. Medicine.
https://journals.lww.com/md-journal/FullText/2014/11040/Kikuchi_Fujimoto_Disease__Retrospective_Study_of.7.aspxDeaver, D., Horna, P., Cualing, H., & Sokol, L. (2014). Pathogenesis, diagnosis, and management of Kikuchi-Fujimoto disease. Cancer Control.
https://journals.sagepub.com/doi/abs/10.1177/107327481402100407