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Multiple areas of skin redness or red spots
Redness of the skin
Redness over different parts of the body
Red spots on skin
Skin is red
My feet are red
Red bumps on skin
Not seeing your symptoms? No worries!
What is Plasmacytosis?
Plasmacytosis occurs when there are excessive numbers of plasma cells (part of the immune system) in the body. This can affect not only the skin but other parts of the body. It is characterized by reddish-brown skin nodules. The cause is unclear but could be viral. This rare condition is more common among Asians.
Typical Symptoms of Plasmacytosis
- Skin over the entire body is red
- Multiple areas of skin redness or red spots
- Swollen lymph nodes or lumps in the neck, armpits, groin, or behind the ears
- Black/blue/brown spots or moles, on the skin and lining of the mouth
- Fever
- Bumpy rash that started on the neck, then spread to the rest of the body
- Bumpy rash that appeared, then rapidly spread to the rest of the body
- Redness, bumps, or irritation on the skin
Diagnostic Questions for Plasmacytosis
Your doctor may ask these questions to check for this disease:
- Is your whole body red?
- Do you have multiple red areas or spots on your skin?
- Do you have any swollen lymph nodes or lumps in your neck, armpits, groin, or behind your ears?
- Are there black, blue, or brown spots on your skin? (Including moles)
- Do you have a fever?
Treatment of Plasmacytosis
There is no standardized, effective treatment regimen. Various regimens with different drugs to suppress inflammation and/or radiation therapy are usually prescribed.
Reviewed By:
Saqib Baig, MD, MS (Pulmonology, Critical Care, Internal Medicine)
Dr. Baig graduated from Army Medical College (NUST) Pakistan in 2007. He did his internal medicine training from Baltimore, Maryland, USA during the years 2009-2013. He joined the internal medicine faculty practice at Medical College of Wisconsin in USA for 2 years before pursuing advanced training. He completed his pulmonary disease and critical care medicine fellowship from Rutgers Robert Wood Johnson Medical School from 2015-2018. | | During his fellowship, Dr. Baig completed his master's in health care services management through Rutgers Business School. He currently serves as the medical director of respiratory therapy and pulmonary function lab and the clinical director of the COPD program at the Jane and Leonard Korman Respiratory Institute at Thomas Jefferson University. He holds the Assistant Professor of Medicine rank at Sidney Kimmel Medical College at Thomas Jefferson University. Dr. Baig's interests lie in respiratory physiology, airways disease, and data science.
Yoshinori Abe, MD (Internal Medicine)
Dr. Abe graduated from The University of Tokyo School of Medicine in 2015. He completed his residency at the Tokyo Metropolitan Health and Longevity Medical Center. He co-founded Ubie, Inc. in May 2017, where he currently serves as CEO & product owner at Ubie. Since December 2019, he has been a member of the Special Committee for Activation of Research in Emergency AI of the Japanese Association for Acute Medicine. | | Dr. Abe has been elected in the 2020 Forbes 30 Under 30 Asia Healthcare & Science category.
Content updated on Mar 31, 2024
Following the Medical Content Editorial Policy
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People with similar symptoms also use Ubie's symptom checker to find possible causes
- Lymph swollen
- Skin has moles or spots of different colors
- Have a fever
- Swollen lymph nodes above collar bone
- Black, blue, or brown spots on the skin or elsewhere
- Swollen armpit
- My body is hot
- Moles or spots of different colors on skin or lining of the mouth
- Swollen lymph nodes continue to grow larger
- Recurrent fevers
- It moves when I touch the lump
- Multiple lymph nodes swollen in my groin
- Periodic fever (>100.4°F / 38°C)
- Lymph nodes in the groin are swollen
- Swollen lymph nodes
See full list
Symptoms Related to Plasmacytosis
Diseases Related to Plasmacytosis
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Link to full study:
https://www.medrxiv.org/content/10.1101/2024.08.29.24312810v1References
LA C, Soyfoo M. Plasmacytosis and nephrotic syndrome revealing Sjögren's syndrome. Arch Rheumatol. 2020 Dec 10;36(2):311-313. doi: 10.46497/ArchRheumatol.2021.8349. PMID: 34527940; PMCID: PMC8418763.
https://archivesofrheumatology.org/full-text/1174Farraj KL, Kaliounji A, Kagolanu D, Khan N. A Rare Case of Extramedullary Plasmacytosis. J Investig Med High Impact Case Rep. 2021 Jan-Dec;9:23247096211040657. doi: 10.1177/23247096211040657. PMID: 34407658; PMCID: PMC8381456.
https://journals.sagepub.com/doi/10.1177/23247096211040657Maxfield L, Casale J, Shah M, Muse ME, Baigrie D. Cutaneous Plasmacytosis Associated with Ehrlichiosis in an African-American Patient. J Clin Aesthet Dermatol. 2021 Mar;14(3):24-27. Epub 2021 Mar 1. PMID: 33841612; PMCID: PMC8021406.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021406/Jain S, Hede RV, Khopkar US. Cutaneous plasmacytosis with mast cell infiltration. Indian J Dermatol Venereol Leprol. 2020 Jan-Feb;86(1):91-95. doi: 10.4103/ijdvl.IJDVL_716_17. PMID: 30073990.
https://ijdvl.com/cutaneous-plasmacytosis-with-mast-cell-infiltration/Yamamoto Y, Matsumura M. Cutaneous plasmacytosis: A rare initial presentation of idiopathic multicentric Castleman's disease. Clin Case Rep. 2021 May 4;9(5):e04109. doi: 10.1002/ccr3.4109. PMID: 34026151; PMCID: PMC8122127.
https://onlinelibrary.wiley.com/doi/10.1002/ccr3.4109