Our Services
Medical Information
Helpful Resources
Published on: 2/27/2026
Persistent fatigue can involve the adrenal glands, but adrenal fatigue is not a recognized diagnosis; the real concern is adrenal insufficiency, a treatable condition that can cause severe tiredness, low blood pressure, weight loss, and salt cravings, and is best confirmed with morning cortisol and an ACTH stimulation test, especially if you recently used steroids. Other common causes like sleep apnea, thyroid problems, iron deficiency, diabetes, medications, and depression are often to blame.
There are several factors to consider. Track symptoms, review steroid use, ask your doctor for basic labs including thyroid, iron, glucose, and morning cortisol, and seek urgent care for severe weakness, vomiting, confusion, or fainting; see complete details below to guide your next steps.
Feeling tired all the time is frustrating. You sleep, drink coffee, try to push through — but the exhaustion lingers. If this sounds familiar, you may have wondered whether your adrenal gland is involved.
Your adrenal glands are small, triangular organs that sit on top of your kidneys. Despite their size, they play a huge role in how you feel every day. When they aren't working properly, fatigue can become overwhelming.
Let's break down what your adrenal gland does, what "crashing" really means, and what safe, medically sound next steps look like.
Your adrenal glands produce several critical hormones, including:
Cortisol is especially important. It helps you wake up in the morning, maintain steady energy, and respond to physical or emotional stress.
If the adrenal gland cannot produce enough of these hormones, your body cannot maintain balance. That's when symptoms can appear.
You may have heard the term "adrenal fatigue." It's widely used online to describe chronic tiredness blamed on stress.
However, major medical organizations do not recognize "adrenal fatigue" as a diagnosable medical condition. There is no strong scientific evidence that stress alone makes otherwise healthy adrenal glands "burn out."
That said, real adrenal gland disorders absolutely exist, and they can be serious.
The most important one to understand is adrenal insufficiency.
Adrenal insufficiency occurs when the adrenal gland does not produce enough cortisol (and sometimes aldosterone). There are two main types:
Unlike vague "adrenal fatigue," adrenal insufficiency is a recognized medical condition that can be life-threatening if untreated.
Symptoms usually develop gradually and may include:
In severe cases, a person can experience an adrenal crisis, which is a medical emergency. Symptoms of adrenal crisis include:
If you suspect this, seek emergency care immediately.
Chronic fatigue is common — but adrenal gland failure is rare. Much more common causes of ongoing tiredness include:
This is why testing matters. Guessing can delay proper treatment.
You may have a higher risk if you:
Stopping long-term steroid therapy suddenly is one of the most common causes of secondary adrenal insufficiency. Always taper steroids under medical supervision.
If your symptoms suggest adrenal insufficiency, a doctor may order:
The ACTH stimulation test checks whether your adrenal gland can respond properly when stimulated. This is a reliable way to confirm or rule out adrenal insufficiency.
The good news: adrenal insufficiency is treatable.
Treatment typically includes:
With proper treatment, most people live normal, full lives.
The key is correct diagnosis.
If your fatigue is persistent and unexplained, it may be helpful to check whether your symptoms align with known patterns of Adrenal Insufficiency (e.g. Addison Disease) using a free AI-powered symptom assessment tool.
This type of tool does not replace medical care, but it can help you understand whether you should seek testing.
You should speak to a doctor urgently if you have:
Adrenal crisis is rare — but it is life-threatening without treatment.
Do not ignore severe symptoms.
If you're exhausted and concerned about your adrenal gland, here's a smart, calm approach:
Track your symptoms
Note when fatigue happens, what makes it worse, and any other physical changes.
Review medications
Especially steroid use — past or present.
Get basic lab work
Ask your doctor about:
Improve foundational habits
Ask about adrenal testing if symptoms persist
Your adrenal gland plays a vital role in energy, stress response, and survival. True adrenal gland failure — such as adrenal insufficiency or Addison disease — is real, diagnosable, and treatable.
However, most people who feel tired do not have adrenal failure. Fatigue has many possible causes, and guessing can delay proper care.
If your exhaustion is severe, persistent, or accompanied by other concerning symptoms, speak to a doctor. Ask about appropriate testing. If anything feels urgent or life-threatening, seek emergency care immediately.
You deserve real answers — not vague labels.
Understanding your adrenal gland is a smart step toward protecting your health.
(References)
* Bornstein, S. R., Allolio, B., Arlt, A., Barthel, A., Don-Wauchope, T., Hammer, G. D., Husebye, E. S., Merke, D. P., Murad, M. H., Nieman, L. K., & Ross, R. J. (2016). Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline. *Journal of Clinical Endocrinology & Metabolism*, *101*(2), 364–389.
* Alexandraki, K., & Grossman, A. B. (2019). Clinical and Therapeutic Aspects of Secondary Adrenal Insufficiency. An Update. *Journal of Clinical Medicine*, *8*(9), 1331.
* Cadegiani, F. A., & Kater, C. E. (2019). Adrenal fatigue does not exist: a systematic review. *Hormones (Athens, Greece)*, *18*(2), 119–130.
* Müller, L. M., Moesgaard, H., & Sørensen, N. D. (2020). Fatigue in endocrine diseases. *Ugeskrift for Læger*, *182*(2), V08190479.
* Tomas, C., Staines, D., & Newton, J. L. (2013). Hypothalamic-pituitary-adrenal axis dysfunction in chronic fatigue syndrome. *ISRN Endocrinology*, *2013*, 765431.
We would love to help them too.
For First Time Users
We provide a database of explanations from real doctors on a range of medical topics. Get started by exploring our library of questions and topics you want to learn more about.
Was this page helpful?
Purpose and positioning of servicesUbie Doctor's Note is a service for informational purposes. The provision of information by physicians, medical professionals, etc. is not a medical treatment. If medical treatment is required, please consult your doctor or medical institution. We strive to provide reliable and accurate information, but we do not guarantee the completeness of the content. If you find any errors in the information, please contact us.