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Published on: 7/15/2026
Can antidepressants cause weight gain? Yes, certain antidepressants are linked to weight gain, though the effect varies by medication type, dosage, and individual factors like metabolism, lifestyle, and genetics. Common culprits include tricyclic antidepressants, some SSRIs (such as paroxetine), and mirtazapine, while others like bupropion are more weight-neutral or may even cause weight loss.
If you're noticing weight changes on your medication—or experiencing other symptoms you can't explain—it's worth getting clarity before making any decisions. Stopping or switching antidepressants without guidance can be risky, but understanding what's driving your symptoms is the first step. Take a free, instant, online symptom check to explore possible causes and get personalized guidance on your next steps.
Reviewed for medical accuracy: 07/15/2026
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Submit your own QuestionAntidepressants are medicines used to help people feel better when they are sad or worried. Some of these medicines can make people gain weight.
Why Do Some Antidepressants Cause Weight Gain?
Which Antidepressants Might Cause Weight Gain?
If you or someone you know is worried about weight gain from antidepressants, it is important to talk to a doctor. They can help find a medicine that works best. If you're experiencing concerning symptoms related to your medication, you can use our free AI symptom checker to better understand what you're experiencing before speaking with your healthcare provider.
(References)
Gill H, Gill B, El-Halabi S, Chen-Li D, Lipsitz O, Rosenblat JD, et al. (2020). Antidepressant Medications and Weight Change. Obesity (Silver Spring, Md.), 33022115.
Fava M. (2000). Weight gain and antidepressants. The Journal of clinical psychiatry, 10926053.
Mouawad M, Nabipur L, & Agrawal DK. (2025). Impact of Antidepressants on Weight Gain - PubMed - NIH. Archives of clinical and biomedical research, 40444017.
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