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Published on: 1/29/2026

Blood in stool and fatigue in females — could this be IBD?

There are several factors to consider. See below to understand more. Blood in stool with fatigue in women can be IBD such as ulcerative colitis or Crohn’s, but it also occurs with hemorrhoids or fissures, infections, iron-deficiency anemia, celiac disease, endometriosis, colon polyps, or colorectal cancer; persistent bleeding, worsening tiredness, dizziness, severe abdominal pain, fever, or a family history should prompt timely medical evaluation with blood and stool tests and possibly colonoscopy, with key details on next steps outlined below.

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Explanation

Blood in Stool and Fatigue in Females — Could This Be IBD?

Seeing Blood in Stool can be alarming, especially when it's paired with ongoing fatigue. Many women wonder whether this combination points to inflammatory bowel disease (IBD) or something less serious. The short answer is: it could be IBD, but there are several other possible causes, some mild and some more serious. Understanding what these symptoms may mean—and when to seek care—can help you take the next right step without unnecessary panic.


What Does "Blood in Stool" Mean?

Blood in Stool refers to visible blood in or on bowel movements, or blood that's only detected through testing. It can look different depending on the source:

  • Bright red blood often comes from the lower digestive tract (rectum, anus, or lower colon).
  • Dark red or maroon blood may suggest bleeding higher in the colon or small intestine.
  • Black, tarry stools can indicate bleeding in the upper digestive tract.

Blood may appear:

  • On toilet paper
  • Coating the stool
  • Mixed into the stool
  • Only on lab testing (occult blood)

Why Fatigue Often Appears Alongside Blood in Stool

Fatigue is a common but often overlooked symptom. When Blood in Stool happens repeatedly, even in small amounts, it can lead to iron-deficiency anemia. This is particularly relevant for females, who may already be at higher risk due to menstruation.

Fatigue related to digestive issues may come from:

  • Chronic blood loss
  • Inflammation in the body
  • Poor nutrient absorption
  • Disrupted sleep due to abdominal pain or urgency

If fatigue persists for weeks or worsens, it deserves medical attention.


Could This Be IBD?

Inflammatory bowel disease (IBD) is a term for chronic conditions that cause inflammation in the digestive tract. The two main types are:

  • Ulcerative colitis – affects the colon and rectum
  • Crohn's disease – can affect any part of the digestive tract

Common IBD Symptoms

Women with IBD may experience:

  • Blood in Stool
  • Chronic diarrhea
  • Abdominal pain or cramping
  • Fatigue or low energy
  • Unintended weight loss
  • Urgency to have bowel movements
  • Mucus in stool

IBD often develops gradually and may flare up and calm down over time. It's not caused by stress, though stress can worsen symptoms.


Other Possible Causes of Blood in Stool and Fatigue

While IBD is one possibility, many other conditions can cause Blood in Stool, fatigue, or both. These include:

More Common and Often Less Serious Causes

  • Hemorrhoids – swollen veins in the rectum; a frequent cause of bright red blood
  • Anal fissures – small tears that cause pain and bleeding
  • Constipation – straining can lead to bleeding
  • Infections – some gut infections cause temporary bleeding and fatigue

Conditions That Need Medical Evaluation

  • Iron-deficiency anemia from chronic blood loss
  • Colon polyps – growths that can bleed
  • Celiac disease – can cause fatigue and nutrient malabsorption
  • Endometriosis involving the bowel – more common in females, sometimes overlooked
  • Colorectal cancer – less common in younger women, but possible and important to rule out

This is why persistent or unexplained Blood in Stool should never be ignored, even if you feel otherwise well.


When Blood in Stool Is More Concerning

Try not to panic—but do take action if you notice any of the following:

  • Blood in Stool that lasts more than a few days
  • Increasing amounts of blood
  • Fatigue that interferes with daily life
  • Dizziness, shortness of breath, or weakness
  • Abdominal pain that is severe or persistent
  • Blood in Stool along with fever or night sweats
  • A personal or family history of IBD or colon cancer

These are reasons to speak to a doctor promptly, as they may signal a serious or life-threatening condition.


How Doctors Evaluate Blood in Stool and Fatigue

A healthcare professional will usually start with a detailed history and physical exam. They may ask about:

  • Stool color and frequency
  • Pain, diarrhea, or constipation
  • Menstrual history
  • Diet and medications
  • Family medical history

Possible Tests

  • Blood tests to check for anemia or inflammation
  • Stool tests to look for infection or hidden blood
  • Colonoscopy or sigmoidoscopy to view the colon
  • Imaging tests if Crohn's disease is suspected

These tests help determine whether IBD is present or if another cause explains your symptoms.


Living With or Treating IBD (If Diagnosed)

If IBD is confirmed, treatment focuses on reducing inflammation, managing symptoms, and preventing complications. Options may include:

  • Anti-inflammatory medications
  • Immune-modulating therapies
  • Iron supplements if anemia is present
  • Dietary adjustments
  • Stress management strategies

Many women with IBD live full, active lives with proper care and monitoring.


A Helpful First Step: Symptom Checking

If you're experiencing these symptoms and want to better understand what might be causing them, Ubie's free AI-powered blood in stool symptom checker can help you assess your situation and determine how urgently you should seek medical care. It takes just a few minutes and provides personalized guidance based on your specific symptoms.


The Bottom Line

  • Blood in Stool and fatigue in females can be linked to IBD, but they are not specific to it.
  • Many conditions—ranging from hemorrhoids to anemia to inflammatory diseases—can cause these symptoms.
  • Persistent, unexplained, or worsening Blood in Stool should always be evaluated by a doctor.
  • Fatigue is not "just stress" when it occurs alongside bleeding.
  • Early evaluation often leads to better outcomes and peace of mind.

If you notice Blood in Stool, especially when combined with fatigue or other symptoms, speak to a doctor. Anything that could be serious or life-threatening deserves timely medical attention. Taking action doesn't mean assuming the worst—it means taking your health seriously.

(References)

  • * Singh S, et al. Fatigue in inflammatory bowel disease: a narrative review. Therap Adv Gastroenterol. 2022 Feb 7;15:17562848221074718. doi: 10.1177/17562848221074718. PMID: 35149303.

  • * Koutroubakis IE, et al. Iron deficiency anemia in inflammatory bowel disease. Ann Gastroenterol. 2020 Jul-Aug;33(4):347-357. doi: 10.20524/aog.2020.0494. Epub 2020 May 29. PMID: 32679267.

  • * Ungaro R, et al. Diagnosis and management of inflammatory bowel disease: A clinical review. JAMA. 2022 May 3;327(17):1706-1721. doi: 10.1001/jama.2022.4290. PMID: 35500057.

  • * Segev L, et al. Sex differences in inflammatory bowel disease. Therap Adv Gastroenterol. 2021 Jun 17;14:17562848211026047. doi: 10.1177/17562848211026047. PMID: 34164821.

  • * Abraham BP. Inflammatory bowel disease: diagnosis and clinical management. J Am Osteopath Assoc. 2021 Sep 1;121(9):781-792. doi: 10.1515/jaoa-2021-0027. PMID: 34484558.

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