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Published on: 3/5/2025

How Does Botox Work for Overactive Bladder (OAB)?

Botox works for overactive bladder by relaxing the bladder muscle, so it contracts less often and reduces the urgent need to go to the bathroom.

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Explanation

Botox is a medicine made from a toxin that helps calm down the nerves in your bladder. When a doctor injects Botox into the wall of the bladder, it blocks a chemical called acetylcholine. This chemical usually tells the bladder muscle to squeeze and makes you feel the need to urinate suddenly. By stopping the action of acetylcholine, Botox helps the bladder muscle to relax. This means the bladder doesn’t tighten too much, which can lower the number of sudden urges and reduce leakage. Most people notice that their symptoms improve, though the effect isn’t permanent. The relief usually lasts for several months, and you might need more injections later on. Botox is given as a series of tiny shots into your bladder by a specialist. As with any treatment, there are some side effects and risks involved, so it’s important to talk with your doctor to see if Botox is a good option for you.

(References)

  • Hsieh PF, Chiu HC, Chen KC, Chang CH, Chou EC. Botulinum toxin A for the Treatment of Overactive Bladder. Toxins (Basel). 2016 Feb 29;8(3):59. doi: 10.3390/toxins8030059. PMID: 26938559; PMCID: PMC4810204.

  • Nitti V, Haag-Molkenteller C, Kennelly M, Chancellor M, Jenkins B, Schurch B. Treatment of neurogenic detrusor overactivity and overactive bladder with Botox (onabotulinumtoxinA): Development, insights, and impact. Medicine (Baltimore). 2023 Jul 1;102(S1):e32377. doi: 10.1097/MD.0000000000032377. PMID: 37499088; PMCID: PMC10374192.

  • Licow-Kamińska AA, Ciećwież SM, Ptak M, Kotlęga D, Brodowska A. Quality of Life in Female Patients with Overactive Bladder after Botulinum Toxin Treatment. Toxins (Basel). 2023 Dec 21;16(1):7. doi: 10.3390/toxins16010007. PMID: 38276531; PMCID: PMC10819285.

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