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Published on: 6/12/2025
Last Update: 6/20/2025

What are the underlying causes of restless leg syndrome?

Restless leg syndrome (RLS) can be caused by problems in how the brain uses iron and also how the brain processes dopamine, a chemical that helps control movement.

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Explanation

Restless leg syndrome (RLS) is a condition that makes people feel like they have to move their legs, especially at night. The exact causes of RLS are not fully understood, but several factors are believed to play a role.

Main Causes:

  1. Iron Deficiency:
  • One major cause is low levels of iron in the brain. Iron is important because it helps the brain use dopamine, a chemical that helps control movement.
  1. Dopamine Dysfunction:
  • Dopamine is a messenger in the brain that helps with movement. In RLS, the way dopamine works may be disprupted.
  1. Genetics:
  • RLS can run in families, which means genes might be involved. Some people are more likely to get RLS because of their family history.
  1. Other Factors:
  • Other things like pregnancy, kidney problems, or certain medications can also make RLS worse.

Understanding these causes can help in managing RLS better. If you have concerns about RLS, it is important to talk to a healthcare provider for proper advice and treatment.

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