What are the potential causes of restless leg syndrome?

Reviewed by Yoshinori Abe, MD

Internal Medicine

Restless Leg Syndrome (RLS) has several known causes, including genetic predisposition, iron deficiency, chronic kidney disease, peripheral nervous system disorders, and side effects from certain medications such as antidepressants, antihistamines, and antipsychotics. Identifying the underlying cause is essential, as treatment strategies vary depending on the trigger.

Because RLS symptoms can overlap with other conditions and root causes differ from person to person, understanding what's driving your discomfort is the first step toward relief. A free, instant, online symptom check can help you clarify your symptoms, explore possible causes, and guide your next steps—whether that's a lifestyle change, a lab test, or a conversation with your doctor.

Reviewed for medical accuracy: 07/14/2026

Important Next Steps

Learn if restless legs need care today Discover likely causes of restless leg syndrome See if your symptoms suggest restless leg syndrome Find OTC options for restless leg relief Find a doctor for restless leg syndrome Understand home remedies for restless leg syndrome Find out if it’s something serious

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Explanation

Restless Leg Syndrome (RLS) is a condition that makes you feel like you have to move your legs, especially at night. There are a few reasons why someone might get RLS.

Genetic Factors: Some people have a higher chance of getting RLS because it runs in their family.
Iron Deficiency: Low levels of iron in the blood can lead to RLS. Iron is important for brain function, and a lack of it might affect how your brain signals your legs.
Kidney Problems: People with kidney disease might have RLS because their kidneys are not working well, which can affect the balance of minerals and vitamins in their body.
Medications: Some medicines can cause RLS as a side effect. These include certain types of antidepressants and medications used to treat nausea.

Understanding these causes can help in managing and treating RLS. If you're experiencing symptoms that concern you, try our free AI symptom checker to get personalized insights, or talk to a healthcare provider for advice and possible treatments.

(References)

Gossard TR, Trotti LM, Videnovic A, & St Louis EK. (2021). Restless Legs Syndrome: Contemporary Diagnosis and .... Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 33880737.
Satija P, & Ondo WG. (2008). Restless legs syndrome: pathophysiology, diagnosis and .... CNS drugs, 18484792.
Carrillo F, & Mir P. (2009). [Symptomatic causes of restless legs syndrome]. Neurologia (Barcelona, Spain), 20340060.

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