What is cefdinir used for?

What Is Cefdinir Used For?

Cefdinir is a third-generation oral cephalosporin antibiotic. It works by interfering with the formation of the bacterial cell wall, causing the bacteria to burst and die. Cefdinir offers broad-spectrum coverage against many of the common bacteria that cause respiratory, skin and soft-tissue infections.

Approved Uses of Cefdinir
Cefdinir is approved by regulatory agencies worldwide for treating a variety of mild to moderate bacterial infections, including:

• Acute bacterial sinusitis
• Community-acquired pneumonia
• Pharyngitis/tonsillitis (strep throat)
• Uncomplicated skin and skin-structure infections (e.g., cellulitis, abscess)
• Acute otitis media (middle ear infection)

Off-Label Applications
Physicians sometimes prescribe cefdinir for other infections when they feel its safety profile and spectrum of activity fit the patient’s needs:

• Acute exacerbations of chronic bronchitis
• Uncomplicated urinary tract infections (in certain regions)
• Lyme disease prophylaxis after a tick bite (in some children)

Dosage and Administration
Dosage of cefdinir varies by age, weight and type of infection:

Adults

• Typical dose: 300 mg twice daily or 600 mg once daily
• Duration: 5–10 days, depending on the infection

Children

• Dose: 7 mg/kg every 12 hours or 14 mg/kg once daily (not to exceed 600 mg/day)
• Duration: usually 5–10 days

Key Points on Administration

• Take with or without food.
• Avoid taking with iron- or aluminum-containing antacids, iron supplements or products with high calcium (e.g., certain infant formulas), as these can reduce absorption.
• If you miss a dose, take it as soon as you remember if it’s within 4 hours of the scheduled time. Otherwise, skip it and go back to your regular schedule.

Contraindications and Precautions

• Allergy to cephalosporins or history of severe penicillin allergy — cross-reactivity can occur.
• History of Clostridioides difficile–associated diarrhea.
• Severe renal impairment (creatinine clearance < 30 mL/min): dosage adjustment is required.
• Use cautiously in pregnancy and breastfeeding; discuss risks and benefits with your doctor.

Side Effects
Most people tolerate cefdinir well. Common side effects include:

• Diarrhea or loose stools
• Nausea, vomiting, abdominal pain
• Headache
• Vaginal yeast infections in women

Less common but important side effects:

• Allergic reactions (rash, itching, anaphylaxis)
• Clostridioides difficile infection (persistent, severe diarrhea)
• Blood disorders (e.g., decreased white blood cells or platelets)
• Changes in liver function tests

Interactions

• Antacids, iron supplements, sucralfate, certain milk products or laxatives containing magnesium may reduce cefdinir absorption—take them at least 2 hours before or after cefdinir.
• Probenecid can increase cefdinir levels by reducing its excretion in the urine.

Use in Special Populations
Pregnancy and Breastfeeding

• Cefdinir is categorized by many authorities as relatively safe in pregnancy (Category B in the US), but you should always discuss antibiotic choices with your obstetrician.
• Small amounts pass into breast milk; monitor breastfed infants for signs of diarrhea or rash.

Children

• Well studied and commonly used in pediatric patients for ear infections, sinusitis and strep throat.
• Adjust dose based on weight and age.

Elderly

• No special concerns beyond standard renal dose adjustments and monitoring for side effects.

Renal Impairment

• For creatinine clearance < 30 mL/min, dosing frequency should be reduced to once daily. Your doctor or pharmacist will calculate the exact regimen.

Monitoring and Follow-Up

• Evaluate symptom improvement within 48–72 hours of starting therapy.
• If no improvement or worsening occurs, contact your healthcare provider.
• Monitor for persistent diarrhea, blood in urine or stool, rash, yellowing of skin/eyes—these may require immediate medical attention.

Reducing Anxiety and Staying Informed
You don’t have to face concerns about your symptoms alone. If you’re not sure whether your condition requires antibiotics, or if you’d like to learn more about what might be causing your symptoms, consider doing a free, online symptom check. This can help guide you on whether a doctor’s visit is needed.

Speak to Your Doctor
This information about cefdinir is intended to be a helpful overview. It does not replace personalized medical advice. Always:

• Tell your doctor about any allergies, other medications or health conditions.
• Complete the full course of antibiotics unless otherwise directed.
• Consult your healthcare provider right away if you experience severe or life-threatening reactions, such as difficulty breathing, high fever, or intense diarrhea.

If you have questions about whether cefdinir is right for you or your child, or if your symptoms are serious or worsening, please speak to a doctor.