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Published on: 2/23/2026
Chest pain from atherosclerosis occurs when plaque builds up and hardens coronary arteries, limiting blood flow and oxygen to the heart; this can cause angina or a heart attack. There are several factors to consider, including your risk profile, symptom patterns, and when to treat it as an emergency. Medically approved next steps range from calling emergency services for severe or new symptoms to prompt medical evaluation, risk screening, lifestyle changes, and treatments like statins, antiplatelets, and procedures when needed. See complete details below to understand which steps fit your situation.
Chest pain can be alarming. Sometimes it's caused by something minor like muscle strain or acid reflux. Other times, it may signal a serious heart problem. One of the most common underlying causes of heart-related chest pain is atherosclerosis — a condition that hardens and narrows the arteries over time.
Understanding how atherosclerosis develops, why it can cause chest pain, and what steps you should take can help you make informed, potentially life-saving decisions.
Atherosclerosis is a chronic condition where fatty deposits (called plaques) build up inside the arteries. These arteries normally carry oxygen-rich blood from your heart to the rest of your body.
Over time, plaque buildup:
When atherosclerosis affects the arteries that supply the heart (coronary arteries), it can lead to coronary artery disease, chest pain (angina), or even a heart attack (myocardial infarction).
This process usually develops slowly over many years — often without symptoms until the blockage becomes severe.
Your heart muscle needs a steady supply of oxygen-rich blood to function properly. When atherosclerosis narrows the coronary arteries:
If a plaque ruptures, it can form a clot that suddenly blocks blood flow. This can cause a heart attack, which requires immediate medical attention.
Chest pain from atherosclerosis doesn't always feel the same for everyone. Common descriptions include:
Some people — especially women, older adults, and people with diabetes — may have less typical symptoms, such as:
If symptoms are sudden, severe, or worsening, call emergency services immediately.
If you're experiencing concerning symptoms and want to understand whether they could be related to a heart attack or unstable angina, you can use this free Myocardial Infarction (MI) / Unstable Angina symptom checker to help assess your risk and determine if you need urgent medical care.
Atherosclerosis is complex, but it often begins with damage to the inner lining of the arteries. Over time, cholesterol, fat, calcium, and other substances build up at the damaged sites.
Major risk factors include:
The more risk factors you have, the higher your likelihood of developing atherosclerosis.
If you report chest pain, a doctor may evaluate you using:
Early detection matters. Many people have atherosclerosis for years before symptoms appear.
If you are experiencing chest pain right now and it is:
Call emergency services immediately.
If your symptoms are mild, recurring, or unclear, the next steps typically include:
Even if the pain goes away, it's important to speak to a doctor. Stable angina can progress to unstable angina or heart attack if left untreated.
Ask your healthcare provider to evaluate:
Lifestyle changes are foundational in treating and preventing atherosclerosis:
These steps can slow or even partially reverse plaque progression.
Doctors may prescribe:
These treatments are evidence-based and significantly reduce the risk of heart attack and stroke.
In cases of severe blockage, procedures may include:
Your cardiologist will determine if these are necessary.
Atherosclerosis is generally considered a chronic condition. However:
Aggressive risk factor control — especially lowering LDL cholesterol — has been shown in major clinical studies to reduce cardiovascular events.
The earlier you take action, the better your outcome.
Never ignore chest pain if it:
While not all chest pain is heart-related, it is safer to rule out dangerous causes than to assume it's harmless.
It's important not to panic. Many cases of chest discomfort are not caused by heart disease. But it's equally important not to dismiss symptoms that could signal a serious issue.
Think of it this way:
If you're unsure, using a structured tool like a free online Myocardial Infarction (MI) / Unstable Angina symptom checker can help you decide whether you need urgent care. But this does not replace professional medical evaluation.
Atherosclerosis is a common and serious condition that hardens and narrows arteries over time. When it affects the heart, it can cause chest pain, unstable angina, or a heart attack.
The good news:
If you are experiencing chest pain — especially if it is new, severe, or accompanied by other symptoms — seek medical care immediately.
Even if symptoms are mild, you should speak to a doctor to rule out anything life-threatening or serious. Early evaluation and treatment save lives.
Taking chest pain seriously isn't overreacting. It's protecting your future.
(References)
* Liberale L, et al. Pathogenesis of atherosclerosis. J Clin Med. 2022 Mar 11;11(6):1524. doi: 10.3390/jcm11061524. PMID: 35329864; PMCID: PMC8955140.
* Gulati M, et al. Evaluation of Chest Pain in Adults: A Review. JAMA. 2021 Mar 16;325(11):1199-1208. doi: 10.1001/jama.2021.1873. PMID: 33724816.
* Knuuti J, et al. 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes. Eur Heart J. 2020 Jan 14;41(3):407-474. doi: 10.1093/eurheartj/ehz425. PMID: 31504439.
* Libby P. The changing landscape of atherosclerosis. Nature. 2021 Jun;594(7863):335-342. doi: 10.1038/s41586-021-03617-x. PMID: 34108711.
* Writing Committee Members, et al. 2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2022 Jan 18;79(2):e21-e129. doi: 10.1016/j.jacc.2021.09.006. Epub 2022 Jan 5. PMID: 34998781.
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