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Published on: 8/20/2026

What could cause chest pain that comes and goes intermittently?

Intermittent chest pain—pain that comes and goes—can stem from a wide range of causes. Common non-cardiac causes include acid reflux (GERD), muscle strain, costochondritis, or anxiety. However, intermittent chest pain can also signal heart-related conditions such as angina or coronary artery disease, as well as nerve-related issues like shingles or pinched nerves. Because symptoms often overlap, identifying the underlying cause requires careful evaluation.

Since intermittent chest pain can range from harmless to serious, it's important not to guess. Take a free, instant, online symptom check to better understand what may be causing your pain and get personalized guidance on your next steps.

Reviewed for medical accuracy: 07/15/2026

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When chest pain comes and goes intermittently, several possibilities could be behind it. Often, acid reflux (or gastroesophageal reflux disease) is a common cause. In this condition, stomach acid irritates the esophagus, leading to chest discomfort that may come and go with meals or changes in body position. Muscle strain or costochondritis—inflammation of the cartilage connecting your ribs to your breastbone—can also cause chest pain that fluctuates over time, especially with movement or pressure on the chest. On the cardiac side, some patients experience what's known as angina, where blood vessels in the heart don't function properly, leading to persistent or recurring chest pain. Additionally, neurological causes, such as nerve irritation or compression, might result in intermittent chest pain as well. Since intermittent chest pain has various different causes, you can use a free AI symptom checker to help identify potential causes based on your specific symptoms, though it's important to discuss your results with a doctor who can perform tests (like an EKG, imaging, or gastrointestinal studies) to determine the precise cause and recommend the appropriate treatment.

(References)

  • Phan A, Shufelt C, Merz CN. Persistent chest pain and no obstructive coronary artery disease. JAMA. 2009 Apr 8;301(14):1468-74. doi: 10.1001/jama.2009.425. PMID: 19351944.

  • Fass R, Achem SR. Noncardiac chest pain: epidemiology, natural course and pathogenesis. J Neurogastroenterol Motil. 2011 Apr;17(2):110-23. doi: 10.5056/jnm.2011.17.2.110. Epub 2011 Apr 27. PMID: 21602987; PMCID: PMC3093002.

  • Khan U, Robbins MS. Neurological Causes of Chest Pain. Curr Pain Headache Rep. 2021 Mar 24;25(5):32. doi: 10.1007/s11916-021-00944-5. PMID: 33760994.

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