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Published on: 2/7/2026
Creatinine levels after 65 require context, because kidney filtration often slows while muscle mass declines, so a normal number can still mask reduced function; typical ranges are about 0.7 to 1.3 mg/dL for older men and 0.6 to 1.1 mg/dL for older women, but trends in eGFR and changes from your baseline matter more. There are several factors to consider, from temporary shifts like dehydration or recent exercise to conditions like CKD, diabetes, or medicines that affect the kidneys, plus red flag symptoms and kidney friendly steps you can take; see below for specific next steps, when to call a doctor urgently, and practical tips to protect your kidneys.
As we age, many parts of the body change—and the kidneys are no exception. One of the most common ways doctors check kidney health is by measuring Creatinine levels in the blood and urine. If you are over 65, you may have noticed your Creatinine levels being discussed more often during routine checkups. This article explains what Creatinine is, why it matters after age 65, what's considered normal, and when it may signal a health concern—using clear, practical language grounded in well-established medical knowledge.
Creatinine is a waste product created when your muscles use energy. Every day, your body produces Creatinine at a fairly steady rate. Healthy kidneys filter it out of the blood and remove it through urine.
Because of this process, Creatinine is a useful marker of kidney function:
Doctors often use Creatinine to estimate something called glomerular filtration rate (eGFR), which gives a broader picture of kidney health.
After 65, several natural changes can affect Creatinine levels and kidney function:
Because muscle mass declines with age, a "normal" Creatinine level in an older adult does not always mean the kidneys are functioning perfectly. This is why doctors rely on trends over time and eGFR rather than a single Creatinine number.
There is no single "perfect" Creatinine level for everyone. Normal ranges vary by sex, body size, and lab methods. In general:
However, these numbers must be interpreted carefully. An older adult may have a Creatinine level in the normal range but still have reduced kidney function due to lower muscle mass.
That's why many doctors focus more on:
Some increases or decreases in Creatinine are not harmful by themselves:
Other causes may need closer medical attention:
These conditions often develop slowly and may not cause symptoms at first, which is why routine blood tests are so important.
Many people with rising Creatinine levels feel completely fine, especially early on. When symptoms do appear, they may include:
These symptoms can have many causes—not just kidney issues—but they should be discussed with a healthcare professional.
If you are experiencing any of these symptoms and want to better understand what they might mean before your next appointment, try Ubie's free Medically approved LLM Symptom Checker Chat Bot to help organize your concerns and get personalized guidance.
Doctors do not rely on Creatinine alone. A complete kidney evaluation may include:
Tracking results over time is often more informative than a single test result.
In many cases, you can support kidney health—even after 65—by focusing on manageable lifestyle steps.
You do not usually need to avoid protein completely. However, excessive protein intake can raise Creatinine levels in some people. A healthcare provider or dietitian can help tailor recommendations to your situation.
Creatinine deserves prompt medical attention if:
These signs can indicate serious kidney stress or other medical conditions. Any potentially life-threatening or rapidly worsening symptoms should be evaluated by a doctor immediately.
Hearing that your Creatinine is "high" can be unsettling. It's important to remember:
At the same time, Creatinine changes should never be ignored. A calm, informed approach—combined with medical guidance—is the healthiest path forward.
If you notice symptoms, test changes, or simply feel unsure, using Ubie's trusted Medically approved LLM Symptom Checker Chat Bot can help you prepare for a meaningful conversation with your healthcare provider.
Creatinine levels offer valuable insight into kidney health, especially after 65—but they are only one piece of the puzzle. Always speak to a doctor about test results, new symptoms, or concerns, particularly if anything feels serious or life-threatening. Early discussion and appropriate care can make a real difference in long-term health and quality of life.
(References)
* Stevens LA, et al. Age-related changes in serum creatinine and GFR-estimating equations: a review. Clin J Am Soc Nephrol. 2011 Nov;6(11):2738-45. PMID: 21088195.
* Levey AS, Stevens LA, Hostetter TH. Estimation of GFR in older adults. Nephrol Dial Transplant. 2007;22 Suppl 9:ix12-9. PMID: 17562726.
* Musso CG, et al. Understanding GFR estimation in the elderly patient. Aging Dis. 2013 Oct 29;4(5):298-306. PMID: 24198909.
* Coresh J, et al. Kidney function and chronic kidney disease in older adults: an international perspective. Lancet. 2013 Mar 2;381(9868):695-703. PMID: 23415250.
* Cirillo M, et al. Creatinine-based GFR estimation in older individuals: an ongoing challenge. J Nephrol. 2021 Oct;34(5):1567-1577. PMID: 33856715.
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