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Published on: 7/15/2026
Yes, depression commonly causes significant fatigue, and low testosterone can independently contribute to tiredness, low mood, and reduced motivation. When these two conditions occur together, their effects often compound — leaving you feeling drained, unfocused, and emotionally flat. Hormonal imbalances and mental health symptoms are closely linked, and identifying the root cause is essential to feeling better.
Because fatigue, low mood, and hormonal shifts can overlap with many other conditions, self-diagnosis is unreliable. A quick, evidence-based assessment can help you understand which symptoms matter most and what to do next. Take a free, instant, online symptom check to clarify what may be driving how you feel and get personalized guidance on your next steps.
Reviewed for medical accuracy: 07/14/2026
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Submit your own QuestionWhen someone feels depressed, they often have little energy and feel very tired. Depression affects how our brain works, which can lower our energy and make everyday activities feel harder. Tiredness is one of the common signs that people with depression report. Testosterone is a hormone that helps keep our energy up and our mood steady. When levels of testosterone are low, a person might feel even more tired and may have a lower mood. In simple words, low testosterone can make it harder to feel energetic and happy. Some studies show that lower testosterone levels are linked with more tiredness and mood problems. This means that both depression and low testosterone can work together to cause fatigue and other symptoms like feeling sad or lacking motivation. If you're experiencing persistent tiredness alongside mood changes, consider using a free symptom checker to better understand what might be causing your symptoms. Understanding this connection can help doctors and patients think about different ways to feel better and improve energy levels.
(References)
Määttänen I, Gluschkoff K, Komulainen K, Airaksinen J, Savelieva K, García-Velázquez R, Jokela M. Testosterone and specific symptoms of depression: Evidence from NHANES 2011-2016. Compr Psychoneuroendocrinol. 2021 Mar 10;6:100044. doi: 10.1016/j.cpnec.2021.100044. PMID: 35757365; PMCID: PMC9216439.
Kheirkhah F, Hosseini SR, Hosseini SF, Ghasemi N, Bijani A, G Cumming R. Relationship between testosterone levels and depressive symptoms in older men in Amirkola, Iran. Caspian J Intern Med. 2014 Spring;5(2):65-70. PMID: 24778779; PMCID: PMC3992230.
Zitzmann M. Testosterone, mood, behaviour and quality of life. Andrology. 2020 Nov;8(6):1598-1605. doi: 10.1111/andr.12867. Epub 2020 Jul 30. PMID: 32657051.
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