Doctors Note Logo

Back

Published on: 3/5/2025

Can Low Testosterone Cause Depression ?

Low testosterone has been linked to depression, as research shows that men with low levels may experience a lower mood and symptoms of depression, though depression can also be influenced by many other factors.

answer background

Explanation

Testosterone plays an important role in regulating mood and overall well-being. Studies have found a connection between low testosterone levels and an increased risk of depression in men. This means that when testosterone is lower than normal, it can sometimes contribute to feelings of sadness, low energy, or irritability. Research also suggests that testosterone therapy might improve mood in some men, although depression often results from a mix of factors such as life circumstances, other medical conditions, and individual biology. In aging men, the natural decline in testosterone levels may make them more vulnerable to mood changes, but it is important to remember that not every man with low testosterone will experience depression. If you or someone you know is experiencing symptoms of depression, it's important to talk with a doctor who can help evaluate your hormone levels along with other possible causes. This allows for a well-rounded approach to treatment, ensuring that any underlying issues contributing to the depression are addressed.

(References)

  • Zitzmann M. Testosterone, mood, behaviour and quality of life. Andrology. 2020 Nov;8(6):1598-1605. doi: 10.1111/andr.12867. Epub 2020 Jul 30. PMID: 32657051.

  • Hauger RL, Saelzler UG, Pagadala MS, Panizzon MS. The role of testosterone, the androgen receptor, and hypothalamic-pituitary-gonadal axis in depression in ageing Men. Rev Endocr Metab Disord. 2022 Dec;23(6):1259-1273. doi: 10.1007/s11154-022-09767-0. Epub 2022 Nov 22. PMID: 36418656; PMCID: PMC9789012.

Tell your friends about us.

We would love to help them too.

smily Shiba-inu looking

For First Time Users

What is Ubie’s Doctor’s Note?

We provide a database of explanations from real doctors on a range of medical topics. Get started by exploring our library of questions and topics you want to learn more about.

Not sure about the cause of your current symptoms?

AI Symptom Check

Try our AI-based symptom check

With an easy 3-min questionnaire, you can get an free AI-powered report on possible causes


Tips to try:

  • Provide specific, detailed info about all symptoms you have.
  • Give accurate information about yourself including current conditions.
  • Answer all follow-up questions

Purpose and positioning of servicesUbie Doctor’s Note is a service for informational purposes, and the provision of information by physicians, medical professionals, etc. is not a medical practice. The provision of information by physicians, medical professionals, etc. is not a medical treatment. If medical treatment is required, please consult your doctor or medical institution. We strive to provide reliable and accurate information, but we do not guarantee the completeness of the content. If you find any errors in the information, please contact us.